Inhibitory effects of genistein and water extracts of various herbs on histamine release
Tóm tắt
Water extracts of eighteen herbal materials and genistein were used to investigate their effects on compound 48/80-induced histamine release in rat peritoneal mast cells (RPMCs). The inhibition effects of histamine release by the water extracts of Ulmus pumila Linne (UP), Lonicera japonica Thunberg (LJT), Angelica gigas Nakai (AGN), Cordyceps militaris (CM), Rehmannia glutinosa Liboschitz (RGL), Liriope platyphylla Wang et Tang (LPWT), Zizyphus jujuba var. inermis Rehder (ZJ) were evaluated by a dose-response assay. LPWT, ZJ, and genistein showed dose-dependent decrease in histamine release at the concentrations of 1 to 1,000 mg/mL, and the inhibition percentage reached up to 31.0, 35.9, and 46.2%, respectively. UP, LJT, AGN, CM, and RGL significantly decreased histamine release at 1 to 100 μg/mL. Among the various combinations, mixture of UP and genistein showed an enhanced inhibition on histamine release.
Tài liệu tham khảo
Alfonso A, Cabado AG, Vieytes MR, and Botana LM (2000) Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell Signal 12, 343–350.
Hachisuka H, Kusuhara M, Higuchi M, Okubo K, and Sasai Y (1998) Purification of rat cutaneous mast cells with percoll density centrifugation. Arch Dematol Research 280, 358–362.
Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, and Sporn PH (2008) A mechanism of benefit of soy genistein in asthma: Inhibition of eosinophil p38-dependent leukotriene synthesis. Clin Exp Allergy 38, 103–112.
Lober K, Alfonso A, Escribano L, and Botana LM (2008) Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation. J Cell Biochem 103, 1070–1088.
Miyake Y, Sasaki S, Ohya Y, Miyamoto S, Matsunaga I, Yoshida T, Hirota Y, and Oda H (2005) Soy, isoflavons, and prevalence of allergic rhinitis in Japanese women: The Osaka Maternal and Child Health Study. J Allergy Clin Immunol 115, 1176–1183.
Peterson LJ, Mosbech H, and Skov PS (1996) Allergeninduced histamine release in intact human skin in vivo assessed by skin micro-dialysis technique: characterization of factors influencing histamine release ability. J Allergy Clin Immunol 97, 672–679.
Wang D, Xia M, and Cui Z (2006) New triterpenoids isolated from the root bark of Ulmus pumila L. Chem Pharm Bull 54, 775–778.
Wang D, Xia M, Cui Z, Tashiro S, Onodera S, and Ikejima T (2004) Cytotoxic effects of manosonone E and F isolated from Ulmus pumila. Bio Pharm Bull 27, 1025–1030.
Yang SO and Ji GE (2006a) Inhibitory effects of Ulmus parvifolia and Liriope platyphylla Wang et Tang on histamine release from rat peritoneal mast cells. Food Sci Biotechnol 15, 363–368.
Yang SO and Ji GE (2006b) Inhibitory effects of Actinidia chinensis and Zizyphus jujube on histamine release from rat peroitonel mast cells. J. Food Sci Nut 11, 89–93.
Yoshikawa M, Murakami T, Ikebata A, Wakao S, Murakami N, and Matsuda H (1997) Bioactive saponins and glycosides. X. On the constituents’ of ziziphi spinosi semen, the seeds of Zizyphus jujube Mill. Var. spinosa Hu (1): structures and histamine release-inhibitory effects of jujubosides A1 and C and acetyljujuboside B. Chem Pharm Bull 45, 1186–1192.