Inhibitory Effects and Related Molecular Mechanisms of Huanglian-Ganjiang Combination Against H1N1 Influenza Virus

Revista Brasileira de Farmacognosia - Tập 33 - Trang 514-522 - 2023
Yao Sun1, Cheng-ling Yu1, Yun-liang Yan1, Feng-ling Zhang1, Jing Chen2, Zi-yi Hu2, Jia He3, Xiong-yu Meng1, Qiao-feng Wu1
1School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China
2School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China
3No. 903 Hospital of PLA Joint Logistic Support Force, Hangzhou, China

Tóm tắt

Influenza is an infectious acute respiratory disease with complications and a high mortality rate; the effective medicines for influenza therapy are limited. “Huanglian” or Coptidis Rhizoma, Coptis chinensis Franch., Ranunculaceae, and “ganjiang” or Zingiberis Rhizoma, Zingiber officinale Roscoe, Zingiberaceae, combination is clinically used for treating respiratory diseases. HPLC was applied for the quantification of berberine hydrochloride (1.101 mg/ml) and 6-gingerol (38.41 μg/ml) in the H2O-soluble extract of the herbal formulation. In this study, the effect of “huanglian”- “ganjiang” extract on influenza virus H1N1-induced acute pulmonary inflammation was evaluated, in addition to the investigation of its anti-influenza mechanism in a mouse model. The analyzed herbal combination inhibited the expression of cytokine IL-6 and stimulated the expression of IL-2 in the serum of influenza virus-infected mice. Meanwhile, the herbal combination downregulated the gene and protein expression levels of TLR3, TLR7, MyD88, RIG-I, MAVS, TRAF3, and NF-κB p65, which are key targets of toll-like and RIG-I-like receptor signaling pathways in mice. In addition, the herbal combination could also promote the combination of intracellular autophagosomes and lysosomes in autophagosome-lysosome formation and improve impaired fusion of autophagosomes and lysosomes by influenza virus. This study suggested that the “huanglian”- “ganjiang” extract may be a candidate therapeutic strategy for the treatment of H1N1 influenza.

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