Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines

Cancer Letters - Tập 265 - Trang 197-205 - 2008
Ji Hye Kim1,2, Ho Yeon Go3, Dong Hoon Jin4, Hwang-Phill Kim5, Myung Hee Hong1,2, Woo-Yeop Chung6, Jong-Hyeong Park6, Jun Bock Jang7, Hee Jung1, Yong Cheol Shin1, Sung-Hoon Kim8, Seong-Gyu Ko1,2
1Lab of Clinical Biology and Pharmacogenomics, Department of Basic Science of Oriental Medicine, College of Oriental Medicine, Kyunghee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
2Institute of Oriental Medicine, Kyunghee University, Seoul 130-701, Republic of Korea
3Department of Internal Medicine, College of Oriental Medicine, Semyung University, Chungju 380-080, Republic of Korea
4Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea
5Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea
6Department of Internal Medicine, College of Oriental Medicine, Kyungwon University, Seongnam 461-701, Republic of Korea
7Department of Obstetrics and Gynecology, College of Oriental Medicine, Kyunghee University, Seoul 130-701, Republic of Korea
8Department of Oriental Pathology, College of Oriental Medicine, Graduate School of East-West Medical Science, Kyunghee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea

Tài liệu tham khảo

Steller, 1995, Mechanism and genes of cells suicide, Science, 267, 1145, 10.1126/science.7878463 Green, 2000, Apoptotic pathways: paper wraps stone blunts scissors, Cell, 102, 1, 10.1016/S0092-8674(00)00003-9 Meier, 2000, Apoptosis in development, Nature, 407, 796, 10.1038/35037734 Nunez, 1998, Caspases: the proteases of the apoptotic pathway, Oncogene, 17, 3237, 10.1038/sj.onc.1202581 Kothakota, 1997, Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis, Science, 278, 294, 10.1126/science.278.5336.294 Martinou, 2001, Breaking the mitochondrial barrior, Nat. Rev. Mol. Cell Biol., 1, 63, 10.1038/35048069 Wang, 2001, The expanding role of mitochondria in apoptosis, Genes Dev., 15, 2922 Adams, 1998, The Bcl-2 protein family: arbiters of cell survival, Science, 281, 1322, 10.1126/science.281.5381.1322 Cory, 2002, The bcl2 family: regulators of the cellular life-or-death switch, Nat. Rev. Cancer, 2, 647, 10.1038/nrc883 Atan, 1999, Bcl-2 family members and the mitochondria in apoptosis, Genes Dev., 13, 1899, 10.1101/gad.13.15.1899 Vivanco, 2002, The phosphatidylinositol 3-Kinase AKT pathway in human cancer, Nat. Rev. Cancer, 7, 489, 10.1038/nrc839 Nicholson, 2002, The protein kinase B/Akt signalling pathway in human malignancy, Cell. Signal., 5, 381, 10.1016/S0898-6568(01)00271-6 Datta, 1999, Cellular survival: a play in three Akts, Genes Dev., 22, 2905, 10.1101/gad.13.22.2905 Brazil, 2001, Ten years of protein kinase B signalling: a hard Akt to follow, Trends Biochem. Sci., 11, 657, 10.1016/S0968-0004(01)01958-2 Hawes, 1996, Phosphatidylinositol 3-kinase is an early intermediate in the Gßγ-mediated mitogen-activated protein kinase signaling pathway, J. Biol. Chem., 271, 12133, 10.1074/jbc.271.21.12133 Downward, 1998, Mechanisms and consequences of activation of protein kinase B/Akt, Curr. Opin. Cell Biol., 2, 262, 10.1016/S0955-0674(98)80149-X Maehama, 1999, PTEN: a tumour suppressor that functions as a phospholipid phosphatase, Trends Cell Biol., 4, 125, 10.1016/S0962-8924(99)01519-6 Sandeep, 1997, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell, 91, 231, 10.1016/S0092-8674(00)80405-5 Cardone, 1998, Regulation of cell death protease caspase-9 by phosphorylation, Science, 5392, 1318, 10.1126/science.282.5392.1318 N.C. Jung, Biological activity of urushiol and flavonoids from Lac tree (Rhus verniciflua Stokes). Ph.D. Thesis, Chonnam National University, Kwang-ju, Republic of Korea, 1998. Lee, 2001, Ethanol eluted extract of Rhus verniciflua Stokes showed both antioxidant and cytotoxic effects on mouse thymocytes depending on the dose and time of the treatment, J. Biochem. Mol. Biol., 34, 250 Kitts, 2001, Antitumorigenic and cytotoxic properties of an ethanol extract derived from Rhus verniciflua Stokes (RVS), J. Toxicol. Environ. Health A, 64, 357, 10.1080/152873901316981330 Lee, 2003, Ethanol-eluted extract of Rhus verniciflua Stokes inhibits cell growth and induces apoptosis in human lymphoma cells, J. Biochem. Mol. Biol., 4, 337, 10.5483/BMBRep.2003.36.4.337 Lee, 2004, Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells, Food Chem. Toxicol., 9, 1383, 10.1016/j.fct.2004.03.012 Kim, 2006, Inhibition of cell cycle progression via p27Kip1 up-regulation and apoptosis induction by an ethanol extract of Rhus verniciflua Stokes in AGS gastric cancer cells, Int. J. Mol. Med., 18, 201 Hang, 2003, Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis, Cancer Res., 63, 4037 Staal, 1987, Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2; amplification of AKT1 in a primary human gastric adenocarcinoma, Proc. Natl. Acad. Sci. USA, 84, 5034, 10.1073/pnas.84.14.5034 Cheng, 1992, AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas, Proc. Natl. Acad. Sci. USA, 89, 9267, 10.1073/pnas.89.19.9267 Cheng, 1996, Amplication of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity antisense RNA, Proc. Natl. Acad. Sci. USA, 93, 3636, 10.1073/pnas.93.8.3636 Bellacosa, 1995, Molecular alterations of the AKT2 oncogene in ovarian breast carcinomas, Int. J. Cancer, 64, 280, 10.1002/ijc.2910640412 Nakatani, 1999, Up-regulation of Akt3 in estrogen receptor deficient breast cancers and androgen-independent prostate cancer lines, J. Biol. Chem., 274, 21528, 10.1074/jbc.274.31.21528 Yamada, 2001, Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis, J. Cell Sci., 114, 2375, 10.1242/jcs.114.13.2375 Stokoe, 1997, 5-trisphosphate in the activation of protein kinase B, Science, 5325, 567, 10.1126/science.277.5325.567 Alessi, 1997, Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha, Curr. Biol., 4, 261, 10.1016/S0960-9822(06)00122-9 Toker, 2000, Akt/Protein Kinase B Is regulated by autophosphorylation at the hypothetical PDK-2 Site, J. Biol. Chem., 12, 8271, 10.1074/jbc.275.12.8271 Kang, 1999, Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit, J. Biol. Chem., 274, 13085, 10.1074/jbc.274.19.13085 Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4 Kops, 1999, Direct control of the Forkhead transcription factor AFX by protein kinase B, Nature, 398, 630, 10.1038/19328 Ozes, 1999, NF-κB activation by tumour necrosis factor requires the Akt serine- threonine kinase, Nature (Lond.), 401, 82, 10.1038/43466 Romashkova, 1999, NF-kB is a target of AKT in anti-apoptotic PDGF signaling, Nature (Lond.), 401, 86, 10.1038/43474 Medema, 2000, AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1, Nature, 404, 782, 10.1038/35008115