Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

Watterson, 1990, Analysis of the molecular basis of calmodulin defects that affect ion channel-mediated cellular responses: site-specific mutagenesis and microinjection, The Journal of cell biology, 111, 2537

Yao, 2008, Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China, Journal of translational medicine, 6, 32, 10.1186/1479-5876-6-32

Pisani, 2005, Global cancer statistics, 2002, CA: a cancer journal for clinicians, 55, 74

Lu, 2009, Nasopharyngeal carcinoma treated with reduced-volume intensity-modulated radiation therapy: report on the 3-year outcome of a prospective series, International journal of radiation oncology, biology, physics, 75, 1071, 10.1016/j.ijrobp.2008.12.015

Wu, 2011, Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management, Radiation oncology, 6, 128, 10.1186/1748-717X-6-128

Bernards, 2009, Protein phosphatase 2A regulatory subunits and cancer, Biochimica et biophysica acta, 1795, 1

Hahn, 2008, Multiple pathways regulated by the tumor suppressor PP2A in transformation, Trends in molecular medicine, 14, 152, 10.1016/j.molmed.2008.02.001

Walter, 2011, Human cancer-associated mutations in the Aalpha subunit of protein phosphatase 2A increase lung cancer incidence in Aalpha knock-in and knockout mice, Molecular and cellular biology, 31, 3832, 10.1128/MCB.05744-11

Odero, 2011, PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect, Leukemia, 25, 606, 10.1038/leu.2010.294

Kast, 2007, CIP2A inhibits PP2A in human malignancies, Cell, 130, 51, 10.1016/j.cell.2007.04.044

Mumby, 2007, PP2A: unveiling a reluctant tumor suppressor, Cell, 130, 21, 10.1016/j.cell.2007.06.034

Boockvar, 2012, Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia, PloS one, 7, e30059, 10.1371/journal.pone.0030059

Zhuang, 2009, Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms, Proceedings of the National Academy of Sciences of the United States of America, 106, 11697, 10.1073/pnas.0905930106

Pacak, 2011, Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy, PloS one, 6, e14678, 10.1371/journal.pone.0014678

Xu, 2011, Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway, European journal of cancer, 47, 2654, 10.1016/j.ejca.2011.08.014

Boger, 2002, Fostriecin: chemistry and biology, Current medicinal chemistry, 9, 2005, 10.2174/0929867023368809

Wang, 2013, Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery, Mini reviews in medicinal chemistry, 13, 1166, 10.2174/1389557511313080005

Lieberman, 2005, gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair, Molecular cell, 20, 801, 10.1016/j.molcel.2005.10.003

Deng, 2009, A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair, Neoplasia, 11, 1012, 10.1593/neo.09720

Cowan, 2010, Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response, Oncogene, 29, 4317, 10.1038/onc.2010.187

Virshup, 2007, Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1, Proceedings of the National Academy of Sciences of the United States of America, 104, 19867, 10.1073/pnas.0709879104

Larner, 2009, PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53, Molecular cancer therapeutics, 8, 135, 10.1158/1535-7163.MCT-08-0457

Kovach, 2009, Enhancement of cancer chemotherapy by simultaneously altering cell cycle progression and DNA-damage defenses through global modification of the serine/threonine phospho-proteome, Cell cycle, 8, 3303, 10.4161/cc.8.20.9689

Lonser, 2010, The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma, Journal of neurosurgery, 113, 225, 10.3171/2009.11.JNS091272

Shi, 2010, A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcoma, Biomaterials, 31, 9535, 10.1016/j.biomaterials.2010.08.059

Walter, 2006, Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint, Molecular and cellular biology, 26, 1997, 10.1128/MCB.26.5.1997-2011.2006

Kufe, 1992, Ionizing radiation activates transcription of the EGR1 gene via CArG elements, Proceedings of the National Academy of Sciences of the United States of America, 89, 10149, 10.1073/pnas.89.21.10149

Scott, 2002, Novel chimeric gene promoters responsive to hypoxia and ionizing radiation, Gene therapy, 9, 1403, 10.1038/sj.gt.3301823

Kroemer, 2004, Cell death by mitotic catastrophe: a molecular definition, Oncogene, 23, 2825, 10.1038/sj.onc.1207528

d'Adda di Fagagna, 2008, Living on a break: cellular senescence as a DNA-damage response, Nature reviews Cancer, 8, 512, 10.1038/nrc2440

Yarm, 2002, Plk phosphorylation regulates the microtubule-stabilizing protein TCTP, Molecular and cellular biology, 22, 6209, 10.1128/MCB.22.17.6209-6221.2002

Telerman, 2008, TCTP protects from apoptotic cell death by antagonizing bax function, Cell death and differentiation, 15, 1211, 10.1038/cdd.2008.18

Telerman, 2004, Translationally controlled tumor protein is a target of tumor reversion, Proceedings of the National Academy of Sciences of the United States of America, 101, 15364, 10.1073/pnas.0406776101

Levine, 2000, Surfing the p53 network, Nature, 408, 307, 10.1038/35042675

Bond, 2008, The genetics of the p53 pathway, apoptosis and cancer therapy, Nature reviews Drug discovery, 7, 979, 10.1038/nrd2656

Hainaut, 2009, Recent advances in p53 research: an interdisciplinary perspective, Cancer gene therapy, 16, 1, 10.1038/cgt.2008.69

Yuan, 2008, Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding, The Journal of biological chemistry, 283, 13707, 10.1074/jbc.M710030200

Hemmings, 2004, Advances in protein kinase B signalling: AKTion on multiple fronts, Trends in biochemical sciences, 29, 233, 10.1016/j.tibs.2004.03.006

Schaffhausen, 2007, Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner, Proceedings of the National Academy of Sciences of the United States of America, 104, 19011, 10.1073/pnas.0706696104

Valsasina, 2010, Phosphorylation of TCTP as a marker for polo-like kinase-1 activity in vivo, Anticancer research, 30, 4973

Barr, 2007, Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1, Nature cell biology, 9, 436, 10.1038/ncb1557

Komuro, 2004, Akt-induced cellular senescence: implication for human disease, Cell cycle, 3, 449

Kroemer, 2002, Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe, Cell death and differentiation, 9, 1287, 10.1038/sj.cdd.4401130

Kolodner, 2010, An overview of Cdk1-controlled targets and processes, Cell division, 5, 11, 10.1186/1747-1028-5-11

Sablina, 2012, Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition, Cancer research, 72, 6414, 10.1158/0008-5472.CAN-12-1667

Chapman, 2004, Radiosensitization of tumour cells by cantharidin and some analogues, International journal of radiation biology, 80, 269, 10.1080/09553000410001679785

Wojcik, 2006, The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor, Mutagenesis, 21, 83, 10.1093/mutage/gel002

Codd, 1990, Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants, FEBS letters, 264, 187, 10.1016/0014-5793(90)80245-E

Gerlich, 2011, Phosphatases: providing safe passage through mitotic exit, Nature reviews Molecular cell biology, 12, 469, 10.1038/nrm3149

Malumbres, 2010, Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55alpha,delta phosphatase, Cancer cell, 18, 641, 10.1016/j.ccr.2010.10.028

Gueven, 2006, The complexity of p53 stabilization and activation, Cell death and differentiation, 13, 941, 10.1038/sj.cdd.4401925

Vassilev, 2004, Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis, The Journal of biological chemistry, 279, 53015, 10.1074/jbc.M410233200

Erikson, 2008, Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint, Oncogene, 27, 3935, 10.1038/onc.2008.36

Sellers, 2008, Drug discovery approaches targeting the PI3K/Akt pathway in cancer, Oncogene, 27, 5511, 10.1038/onc.2008.246

Yang-Yen, 2007, A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner, Molecular biology of the cell, 18, 2525, 10.1091/mbc.e07-02-0188

Morgan, 2013, Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair, Clinical cancer research : an official journal of the American Association for Cancer Research, 19, 4422, 10.1158/1078-0432.CCR-13-0788

Luo, 2011, Gefitinib enhances the radiosensitivity of nasopharyngeal carcinoma cell line CNE2 in vitro, Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 31, 991

Yu, 2003, Abrogation of radiation-induced G2 arrest and radiosensitization by7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line, Ai zheng = Aizheng = Chinese journal of cancer, 22, 6

Sun, 2012, Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor, Cancer research, 72, 282, 10.1158/0008-5472.CAN-11-2866