Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by α-tocopheryl succinate

Chowdhury, 2005, High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines, Biochem Biophys Res Commun, 333, 1139, 10.1016/j.bbrc.2005.06.017 Constantinou, 2008, Vitamin E and cancer: an insight into the anticancer activities of vitamin E isomers and analogs, Int J Cancer, 123, 739, 10.1002/ijc.23689 Dong, 2008, α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II, Oncogene, 27, 4324, 10.1038/onc.2008.69 Donnellan, 1970, Localization of the l-glycerol 1-phosphate-flavoprotein oxidoreductase on the outer surface of the inner membrane of insect flight-muscle mitochondria, Biochem J, 116, 31P, 10.1042/bj1160031Pa Dos Santos, 2012, α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo, Leukemia, 26, 451, 10.1038/leu.2011.216 Drahota, 2002, Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide, J Bioenerg Biomembr, 34, 105, 10.1023/A:1015123908918 Enzmann, 1989, Unusual histochemical pattern in preneoplastic hepatic foci characterized by hyperactivity of several enzymes, Virchows Arch B: Cell Pathol Incl Mol Pathol, 57, 99, 10.1007/BF02899070 Fariss, 2001, Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria, Free Radical Biol Med, 31, 530, 10.1016/S0891-5849(01)00615-3 Gruber, 2014, Tocopheramine succinate and tocopheryl succinate: mechanism of mitochondrial inhibition and superoxide radical production, Bioorg Med Chem, 22, 684, 10.1016/j.bmc.2013.12.036 Haller, 1994, A respirometer for investigating oxidative cell metabolism: toward optimization of respiratory studies, Anal Biochem, 218, 338, 10.1006/abio.1994.1188 Hittelman, 1969, Oxidative phosphorylation and compartmentation of fatty acid metabolism in brown fat mitochondria, Eur J Biochem, 11, 183, 10.1111/j.1432-1033.1969.tb00759.x Jha, 1999, (d-α-Tocopheryl succinate) decreases mitotic accumulation in gamma-irradiated human tumor, but not in normal cells, Nutr Cancer, 35, 189, 10.1207/S15327914NC352_14 Klingenberg, 1970, Localization of the glycerol-phosphate dehydrogenase in the outer phase of the mitochondrial inner membrane, Eur J Biochem, 13, 247, 10.1111/j.1432-1033.1970.tb00924.x Kluckova, 2013, Mitochondrial complex II, a novel target for anti-cancer agents, Biochim Biophys Acta, 1827, 552, 10.1016/j.bbabio.2012.10.015 Kogure, 2004, Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of α-tocopheryl esters, Biochim Biophys Acta, 1672, 93, 10.1016/j.bbagen.2004.03.001 Lenaz, 1995, Modes of coenzyme Q function in electron transfer, Protoplasma, 184, 50, 10.1007/BF01276901 Lenaz, 2009, Structural and functional organization of the mitochondrial respiratory chain: a dynamic super-assembly, Int J Biochem Cell Biol, 41, 1750, 10.1016/j.biocel.2009.04.003 Lowry, 1951, Protein measurement with the Folin phenol reagent, J Biol Chem, 193, 265, 10.1016/S0021-9258(19)52451-6 Neuzil, 2007, Vitamin E analogs, a novel group of “mitocans,” as anticancer agents: the importance of being redox-silent, Mol Pharmacol, 71, 1185, 10.1124/mol.106.030122 Neuzil, 2001, Selective cancer cell killing by α-tocopheryl succinate, Br J Cancer, 84, 87, 10.1054/bjoc.2000.1559 Pedersen, 1978, Tumor mitochondria and the bioenergetics of cancer cells, Prog Exp Tumor Res, 22, 190, 10.1159/000401202 Ragan, 1985, The kinetics of quinone pools in electron transport, Biochim Biophys Acta, 811, 13, 10.1016/0304-4173(85)90003-5 Rauchová, 1992, Coenzyme Q-pool function in glycerol-3-phosphate oxidation in hamster brown adipose tissue mitochondria, J Bioenerg Biomembr, 24, 235, 10.1007/BF00762682 Rauchová, 1997, Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria, Arch Biochem Biophys, 344, 235, 10.1006/abbi.1997.0150 Rauchová, 2006, Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone, Biochem Biophys Res Commun, 339, 362, 10.1016/j.bbrc.2005.11.035 Shiau, 2006, α-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function, J Biol Chem, 281, 11819, 10.1074/jbc.M511015200 Sun, 2005, Crystal structure of mitochondrial respiratory membrane protein complex II, Cell, 121, 1043, 10.1016/j.cell.2005.05.025 Yu, 1978, Evidence for the existence of a ubiquinone protein and its radical in the cytochromes b and c1 region in the mitochondrial electron transport chain, Biochem Biophys Res Commun, 82, 1070, 10.1016/0006-291X(78)90296-6