Inhibition of macrophage nitric oxide production by tetrahydrocannabinol in vivo and in vitro

International Journal of Immunopharmacology - Tập 18 Số 12 - Trang 749-752 - 1996
Ronald G. Coffey1,2, Elizabeth Snella1, Karen M. Johnson2, Susan Pross1
1Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL 33612, U.S.A.
2Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, FL 33612, U.S.A.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Burnette-Curley, 1993, Delta-9- tetrahydrocannabinol inhibits cell contact-dependent cytotoxicity of Bacillus Calmette-Guerin-activated macrophages, Int. J. Immunopharmac, 15, 371, 10.1016/0192-0561(93)90048-4

Diaz, 1993, Suppression of lymphocyte adenosine 3′:5′-cyclic monophosphate (cAMP) by A-9-tetrahydrocannabinol, Int. J. Immunopharmac, 15, 523, 10.1016/0192-0561(93)90067-9

Diaz, 1994, The effect of A-9-tetrahydro-cannabinol on arachidonic acid metabolism in human peripheral blood mononuclear cells, J. Pharmac. exp. Therap, 268, 1289

Ding, 1988, Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages, 141, 2407

Felder, 1992, Cannabinoid agonists stimulate both receptor-and non-receptor mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones, Mol. Pharmac, 42, 838

Fischer-Stenger, 1993, Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-α: suppression of post-translational events, J. Pharmac. exp. Therap, 267, 1558

Green, 1982, Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal. Biochem, 126, 131, 10.1016/0003-2697(82)90118-X

Higuchi, 1990, Cytolytic mechanisms of activated macrophages, 144, 1425

Howlett, 1986, Involvement of G1 in the inhibition of adenylate cyclase by cannabimimetic drugs, Mol. Pharmac, 29, 307

Kaminski, 1994, Mechanisms of immune modulation by cannabinoids, 349

Kaminski, 1992, Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation, Mol. Pharmac, 42, 736

Kaminski, 1994, Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G protein coupled mechanism, Biochem. Pharmac, 48, 1899, 10.1016/0006-2952(94)90588-6

Klein, 1993, Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila, J. Pharmac. exp. Therap, 267, 635

Laychock, 1986, Pancreatic islet arachidonic acid turnover and metabolism and insulin release in response to delta-9-tetrahydrocannabinol, Biochem. Pharmac, 25, 2003, 10.1016/0006-2952(86)90733-1

Lopez-Cepero, 1986, Tetrahydrocannabinol- induced suppression of macrophage spreading and phagocytic activity in vitro, J. Leukoc. Biol, 39, 679, 10.1002/jlb.39.6.679

MacMickling, 1995, Altered responses to bacterial infection and endotoxic shock in ice lacking inducible nitric oxide synthase, Cell, 81, 641, 10.1016/0092-8674(95)90085-3

Munro, 1993, Molecular characterization of a peripheral receptor for cannabinoids, Nature, 365, 61, 10.1038/365061a0

Nathan, 1991, Role of nitric oxide synthesis in macrophage antimicrobial activity, Curr. Opinion Immunol, 3, 65, 10.1016/0952-7915(91)90079-G

Newton, 1994, Secondary immunity to Legionella pneumophila and TH1 activity are suppressed by A9-tetrahydrocannabinol injection, Infection Immunity, 62, 4015, 10.1128/IAI.62.9.4015-4020.1994

Pross, 1992, Suppressive effect of tetrahydrocannabinol on specific T cell subpopulations in the thymus, Thymus, 19, 97

Specter, 1991, Delta-9-tetrahydrocannabinol augments murine retroviral induced immunosuppression and infection, Int. J. Immunopharmac, 13, 411, 10.1016/0192-0561(91)90011-U

Vandeloosdrecht, 1994, A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia, J. Immunol. Meth, 174, 311, 10.1016/0022-1759(94)90034-5

Weinberg, 1994, J. exp. Med, 179, 651, 10.1084/jem.179.2.651

Zheng, 1992, Inhibition by delta-9-tetrahydrocannabinol of tumor necrosis factor alpha production by mouse and human macrophages, Int. J. Immunopharmac, 14, 1445, 10.1016/0192-0561(92)90017-F