Inhibition of large T antigen ATPase activity as a potential strategy to develop anti-polyomavirus JC drugs

Ahn, 2008, Selection of internal reference genes for SYBR green qRT-PCR studies of rhesus monkey (Macaca mulatta) tissues, BMC Mol. Biol., 9, 78, 10.1186/1471-2199-9-78 Brickelmaier, 2009, Identification and characterization of mefloquine efficacy against JC virus in vitro, Antimicrob. Agents Chemother., 53, 1840, 10.1128/AAC.01614-08 Carbone, 2003, High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancers, Virology, 315, 409, 10.1016/S0042-6822(03)00547-6 Clifford, 2013, A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes, J. Neurovirol., 19, 351, 10.1007/s13365-013-0173-y Clifford, 1999, HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy, Neurology, 52, 623, 10.1212/WNL.52.3.623 Elphick, 2004, The human polyomavirus, JCV, uses serotonin receptors to infect cells, Science, 306, 1380, 10.1126/science.1103492 Freim Wahl, 2007, Progressive multifocal leukoencephalopathy in a lymphoma patient with complete remission after treatment with cytostatics and rituximab: case report and review of the literature, Clin. Neuropathol., 26, 68, 10.5414/NPP26068 Gai, 2004, Insights into the oligomeric states, conformational changes, and helicase activities of SV40 large tumor antigen, J. Biol. Chem., 279, 38952, 10.1074/jbc.M406160200 Gallia, 1997, Review: JC virus infection of lymphocytes-revisited, J. Infect. Dis., 176, 1603, 10.1086/514161 Hall, 2008, Estimation of HIV incidence in the United States, JAMA, 300, 520, 10.1001/jama.300.5.520 Kleinschmidt-DeMasters, 2005, Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis, N. Engl. J. Med., 353, 369, 10.1056/NEJMoa051782 Kranick, 2007, Progressive multifocal leukoencephalopathy after rituximab in a case of non-Hodgkin lymphoma, Neurology, 69, 704, 10.1212/01.wnl.0000267325.06000.d9 Lafon, 1998, JC virus remains latent in peripheral blood B lymphocytes but replicates actively in urine from AIDS patients, J. Infect. Dis., 177, 1502, 10.1086/515305 Langer-Gould, 2005, Progressive multifocal leukoencephalopathy in a patient treated with natalizumab, N. Engl. J. Med., 353, 375, 10.1056/NEJMoa051847 Li, 2009, Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigens, J. Virol., 83, 37, 10.1128/JVI.00844-08 Major, 1997, Viral induced demyelination leading to progressive multifocal leukoencephalopathy: the involvement of both immune and nervous system target cells, 305 Monaco, 1996, JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency, J. Virol., 70, 7004, 10.1128/JVI.70.10.7004-7012.1996 Nelson, 2013, A retrograde trafficking inhibitor of ricin and shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses, MBio, 4, 10.1128/mBio.00729-13 Neu, 2010, Structure–function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif, Cell Host Microbe, 8, 309, 10.1016/j.chom.2010.09.004 Seguin, 2012, High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity, J. Biomol. Screen., 17, 194, 10.1177/1087057111421630 Seguin, 2012, A screen for modulators of large T antigen’s ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication, Antiviral Res., 96, 70, 10.1016/j.antiviral.2012.07.012 Sullivan, 2002, T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis, Microbiol. Mol. Biol. Rev., 66, 179, 10.1128/MMBR.66.2.179-202.2002 Topalis, 2013, The large tumor antigen: a “Swiss Army knife” protein possessing the functions required for the polyomavirus life cycle, Antiviral Res., 97, 122, 10.1016/j.antiviral.2012.11.007 Watanabe, 2013, Formation of covalently modified folding intermediates of simian virus 40 Vp1 in large T antigen-expressing cells, J. Virol., 87, 5053, 10.1128/JVI.00955-12 Weber, 2001, Cellular and humoral immune response in progressive multifocal leukoencephalopathy, Ann. Neurol., 49, 636, 10.1002/ana.1004 Wright, 2008, Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation, Bioorg. Med. Chem., 16, 3291, 10.1016/j.bmc.2007.12.014 Wright, 2009, Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen, Virus Res., 141, 71, 10.1016/j.virusres.2008.12.018