Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer

Gut - Tập 66 Số 6 - Trang 1106-1115 - 2017
Tijana Borovski1, Thomas T. Vellinga1, Jamila Laoukili1, Evan E. Santo2, Szabolcs Fátrai3, Susanne van Schelven1, André Verheem1, Dieuwke L. Marvin1, Inge Ubink1, Inne H.M. Borel Rinkes1, Onno Kranenburg4
1Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands
2Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, New York, USA
3Department of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands
4Cancer Center, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands

Tóm tắt

Từ khóa


Tài liệu tham khảo

Prenen, 2010, New strategies for treatment of KRAS mutant metastatic colorectal cancer, Clin Cancer Res, 16, 2921, 10.1158/1078-0432.CCR-09-2029

Hüser, 2001, MEK kinase activity is not necessary for Raf-1 function, EMBO J, 20, 1940, 10.1093/emboj/20.8.1940

Mikula, 2001, Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene, EMBO J, 20, 1952, 10.1093/emboj/20.8.1952

O'Neill, 2004, Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1, Science, 306, 2267, 10.1126/science.1103233

Chen, 2001, Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism, Proc Natl Acad Sci USA, 98, 7783, 10.1073/pnas.141224398

Piazzolla, 2005, Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling, J Cell Biol, 171, 1013, 10.1083/jcb.200504137

Hoogwater, 2010, Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells, Gastroenterology, 138, 2357, 10.1053/j.gastro.2010.02.046

Ehrenreiter, 2009, Raf-1 addiction in Ras-induced skin carcinogenesis, Cancer Cell, 16, 149, 10.1016/j.ccr.2009.06.008

Blasco, 2011, c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma, Cancer Cell, 19, 652, 10.1016/j.ccr.2011.04.002

Emuss, 2005, Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF, Cancer Res, 65, 9719, 10.1158/0008-5472.CAN-05-1683

Marisa, 2013, Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value, PLoS Med, 10, e1001453, 10.1371/journal.pmed.1001453

Jorissen, 2009, Metastasis-associated gene expression changes predict poor outcomes in patients with dukes stage B and C colorectal cancer, Clin Cancer Res, 15, 7642, 10.1158/1078-0432.CCR-09-1431

Smith, 2010, Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer, Gastroenterology, 138, 958, 10.1053/j.gastro.2009.11.005

Emmink, 2011, Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan, Gastroenterology, 141, 269, 10.1053/j.gastro.2011.03.052

van de Wetering, 2015, Prospective derivation of a living organoid biobank of colorectal cancer patients, Cell, 161, 933, 10.1016/j.cell.2015.03.053

Muraro, 2012, CD133+, CD166+CD44+, and CD24+CD44+ phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal cancer cell lines, Stem Cells Transl Med, 1, 592, 10.5966/sctm.2012-0003

Lehmann, 2012, Established breast cancer stem cell markers do not correlate with in vivo tumorigenicity of tumor-initiating cells, Int J Oncol, 41, 1932, 10.3892/ijo.2012.1654

Rocco, 2012, CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumors, J Cell Physiol, 227, 2686, 10.1002/jcp.23013

Shin, 2006, Tight junctions and cell polarity, Annu Rev Cell Dev Biol, 22, 207, 10.1146/annurev.cellbio.22.010305.104219

Jockusch, 1996, Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation, Trends Cell Biol, 6, 311, 10.1016/0962-8924(96)10022-2

Ziegler, 2006, The structure and regulation of vinculin, Trends Cell Biol, 16, 453, 10.1016/j.tcb.2006.07.004

Desideri, 2015, Alike but different: RAF Paralogs and their signaling outputs, Cell, 161, 967, 10.1016/j.cell.2015.04.045

Breunig, 2014, BRaf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma, Clin Cancer Res, 20, 2410, 10.1158/1078-0432.CCR-13-1635

Karreth, 2011, C-Raf is required for the initiation of lung cancer by K-Ras(G12D), Cancer Discov, 1, 128, 10.1158/2159-8290.CD-10-0044

Baas, 2004, Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD, Cell, 116, 457, 10.1016/S0092-8674(04)00114-X

Lee, 2008, Cell polarity and cancer—cell and tissue polarity as a non-canonical tumor suppressor, J Cell Sci, 121, 1141, 10.1242/jcs.016634

Slattum, 2014, Tumour cell invasion: an emerging role for basal epithelial cell extrusion, Nat Rev Cancer, 14, 495, 10.1038/nrc3767

Osanai, 2006, Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes, Cancer Res, 66, 9125, 10.1158/0008-5472.CAN-06-1864

Hoevel, 2004, Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids, Int J Cancer, 108, 374, 10.1002/ijc.11571

Michl, 2003, Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer, Cancer Res, 63, 6265

Mullin, 2000, Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers, Ann N Y Acad Sci, 915, 231, 10.1111/j.1749-6632.2000.tb05246.x

Li, 2000, Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin, J Cell Biol, 148, 791, 10.1083/jcb.148.4.791

Prahallad, 2012, Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR, Nature, 483, 100, 10.1038/nature10868

Wee, 2009, PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers, Cancer Res, 69, 4286, 10.1158/0008-5472.CAN-08-4765

Sun, 2014, Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3, Cell Rep, 7, 86, 10.1016/j.celrep.2014.02.045

Lito, 2014, Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors, Cancer Cell, 25, 697, 10.1016/j.ccr.2014.03.011

Lamba, 2014, RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells, Cell Rep, 8, 1475, 10.1016/j.celrep.2014.07.033