Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells

Vanden Bossche, 2003, Antifungal agents of use in animal health—chemical, biochemical and pharmacological aspects, J Vet Pharmacol Ther, 26, 5, 10.1046/j.1365-2885.2003.00456.x Venkatakrishnan, 2000, Effects of the antifungal agents on oxidative drug metabolism: clinical relevance, Clin Pharmacokinet, 38, 111, 10.2165/00003088-200038020-00002 Roman, 2002, P-450 metabolites of arachidonic acid in the control of cardiovascular function, Physiol Rev, 82, 131, 10.1152/physrev.00021.2001 Zeldin, 2001, Epoxygenase pathways of arachidonic acid metabolism, J Biol Chem, 276, 36059, 10.1074/jbc.R100030200 Lu, 2005, Impaired archidonic acid-mediated activation of large-conductance Ca2+-activated K+channels in coronary arterial smooth muscle cells in Zucker Diabetic Fatty Rats, Diabetes, 54, 2155, 10.2337/diabetes.54.7.2155 Zhou, 2005, Impaired arachionic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats, Am J Physiol, 288, H2210 Brash, 2001, Arachidonic acid as a bioactive molecule, J Clin Invest, 107, 1339, 10.1172/JCI13210 Spector, 2004, Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function, Prog Lipid Res, 43, 55, 10.1016/S0163-7827(03)00049-3 Halcox, 2001, Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation, Am J Physiol Heart Circ Physiol, 280, H2470, 10.1152/ajpheart.2001.280.6.H2470 Huang, 2004, Estrogen elicits cytochrome P450—mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation, Circ Res, 94, 245, 10.1161/01.RES.0000111525.96232.46 Campbell, 1996, Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors, Circ Res, 78, 415, 10.1161/01.RES.78.3.415 Nasrallah, 2005, Prostacyclin signaling in the kidney: implications for health and disease, Am J Physiol Renal Physiol, 289, F235, 10.1152/ajprenal.00454.2004 MacMillan, 1998, Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings, Recent Prog Horm Res, 53, 25 Greney, 2000, Coupling of I(1) imidazoline receptors to the cAMP pathway: studies with a highly selective ligand, benazoline, Mol Pharmacol, 57, 1142 Clark, 2004, Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists [corrected], Bioorg Med Chem Lett, 14, 1053, 10.1016/j.bmcl.2003.10.070