Inhibition of P-Glycoprotein Leads to Improved Oral Bioavailability of Compound K, an Anticancer Metabolite of Red Ginseng Extract Produced by Gut Microflora
Tóm tắt
Từ khóa
Tài liệu tham khảo
Akao, 1998, Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration–measurement of compound K by enzyme immunoassay, Biol Pharm Bull, 21, 245, 10.1248/bpb.21.245
Akao, 1998, Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng, J Pharm Pharmacol, 50, 1155, 10.1111/j.2042-7158.1998.tb03327.x
Hasegawa, 1994, Interactions of ginseng extract, ginseng separated fractions, and some triterpenoid saponins with glucose transporters in sheep erythrocytes, Planta Med, 60, 153, 10.1055/s-2006-959440
Hu, 1994, The Caco-2 cell monolayers as an intestinal metabolism model: metabolism of dipeptide Phe-Pro, J Drug Target, 2, 79, 10.3109/10611869409015895
Lee, 2006, Pharmacokinetic characteristics and hepatic distribution of IH-901, a novel intestinal metabolite of ginseng saponin, in rats, Planta Med, 72, 204, 10.1055/s-2005-916201
Meerum Terwogt, 1998, Co-administration of cyclosporin enables oral therapy with paclitaxel, Lancet, 352, 285, 10.1016/S0140-6736(98)24030-X
Qian, 2005, In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3, J Chromatogr B Analyt Technol Biomed Life Sci, 816, 223, 10.1016/j.jchromb.2004.11.036
Wang, 2012, Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer, Int J Oncol, 40, 1970