Inhibition of Histone Deacetylases Preserves Myocardial Performance and Prevents Cardiac Remodeling through Stimulation of Endogenous Angiomyogenesis

Antos, 2003, Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors, J Biol Chem, 278, 28930, 10.1074/jbc.M303113200

Beltrami, 2003, Adult cardiac stem cells are multipotent and support myocardial regeneration, Cell, 114, 763, 10.1016/S0092-8674(03)00687-1

Chen, 2011, HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway, J Cell Biochem, 112, 3246, 10.1002/jcb.23251

Chen, 2001, Duration of nuclear NF-κB action regulated by reversible acetylation, Science, 293, 1653, 10.1126/science.1062374

Cheng, 2010, Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction, Circ Res, 106, 1570, 10.1161/CIRCRESAHA.109.212589

Cheung, 2000, Signaling to chromatin through histone modifications, Cell, 103, 263, 10.1016/S0092-8674(00)00118-5

Fischle, 1999, Saccharomyces cerevisiae HDA1p, J Biol Chem, 274, 11713, 10.1074/jbc.274.17.11713

Frederick, 2010, Stromal cell-derived factor-1α activation of tissue-engineered endothelial progenitor cell matrix enhances ventricular function after myocardial infarction by inducing neovasculogenesis, Circulation, 122, S107

Granger, 2008, Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice, FASEB J, 22, 3549, 10.1096/fj.08-108548

Grozinger, 1999, Three proteins define a class of human histone deacetylases related to yeast Hda1p, Proc Natl Acad Sci U S A, 96, 4868, 10.1073/pnas.96.9.4868

Haberland, 2009, The many roles of histone deacetylases in development and physiology: implications for disease and therapy, Nat Rev Genet, 10, 32, 10.1038/nrg2485

Hansen, 1998, Structure and function of the core histone N-termini: more than meets the eye, Biochemistry, 37, 17637, 10.1021/bi982409v

Hassig, 1998, A role for histone deacetylase activity in HDAC1-mediated transcriptional repression, Proc Natl Acad Sci U S A, 95, 3519, 10.1073/pnas.95.7.3519

Huangfu, 2008, Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2, Nat Biotechnol, 26, 1269, 10.1038/nbt.1502

1996

Kee, 2006, Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding, Circulation, 113, 51, 10.1161/CIRCULATIONAHA.105.559724

Kong, 2006, Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy, Circulation, 113, 2579, 10.1161/CIRCULATIONAHA.106.625467

Laugwitz, 2005, Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages, Nature, 433, 647, 10.1038/nature03215

Lee, 2007, Inhibition of histone deacetylase on ventricular remodeling in infarcted rats, Am J Physiol Heart Circ Physiol, 293, H968, 10.1152/ajpheart.00891.2006

Loffredo, 2011, Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair, Cell Stem Cell, 8, 389, 10.1016/j.stem.2011.02.002

Luger, 1997, Crystal structure of the nucleosome core particle at 2.8 Å resolution, Nature, 389, 251, 10.1038/38444

Mangi, 2003, Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts, Nat Med, 9, 1195, 10.1038/nm912

Matsuura, 2009, Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice, J Clin Invest, 119, 2204

Oh, 2003, Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction, Proc Natl Acad Sci U S A, 100, 12313, 10.1073/pnas.2132126100

Ren, 2004, Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction, J Neurochem, 89, 1358, 10.1111/j.1471-4159.2004.02406.x

Samant, 2011, HDAC3-dependent reversible lysine acetylation of cardiac myosin heavy chain isoforms modulates their enzymatic and motor activity, J Biol Chem, 286, 5567, 10.1074/jbc.M110.163865

Surani, 2007, Genetic and epigenetic regulators of pluripotency, Cell, 128, 747, 10.1016/j.cell.2007.02.010

Strahl, 2000, The language of covalent histone modifications, Nature, 403, 41, 10.1038/47412

Tang, 2010, Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction, Circulation, 121, 293, 10.1161/CIRCULATIONAHA.109.871905

Tseng, 2010, Effect of disruption of Akt-1 of lin(−)c-kit(+) stem cells on myocardial performance in infarcted heart, Cardiovasc Res, 87, 704, 10.1093/cvr/cvq110

Turner, 2000, Histone acetylation and an epigenetic code, Bioessays, 22, 836, 10.1002/1521-1878(200009)22:9<836::AID-BIES9>3.0.CO;2-X

Verdin, 2003, Class II histone deacetylases: versatile regulators, Trends Genet, 19, 286, 10.1016/S0168-9525(03)00073-8

Vigushin, 2004, Targeted histone deacetylase inhibition for cancer therapy, Curr Cancer Drug Targets, 4, 205, 10.2174/1568009043481560

Wang, 1999, HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor, Mol Cell Biol, 19, 7816, 10.1128/MCB.19.11.7816

Ware, 2009, Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells, Cell Stem Cell, 4, 359, 10.1016/j.stem.2009.03.001

Yuan, 2005, Stat3 dimerization regulated by reversible acetylation of a single lysine residue, Science, 307, 269, 10.1126/science.1105166

Zhang, 2010, Targeted deletion of NF-κB p50 diminishes the cardioprotection of histone deacetylase inhibition, Am J Physiol Heart Circ Physiol, 298, H2154, 10.1152/ajpheart.01015.2009

Zhao, 2006, Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts, J Pharmacol Exp Ther, 317, 1106, 10.1124/jpet.106.100982

Zhao, 2002, Late preconditioning elicited by activation of adenosine A3 receptor in heart: role of NF-κB, iNOS and mitochondrial K(ATP) channel, J Mol Cell Cardiol, 34, 263, 10.1006/jmcc.2001.1510

Zhao, 2007, Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury, Cardiovasc Res, 76, 473, 10.1016/j.cardiores.2007.08.010

Zhao, 2008, Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction, J Appl Physiol, 104, 1793, 10.1152/japplphysiol.01109.2007

Zhao, 2010, gp-91 mediates histone deacetylase inhibition-induced cardioprotection, Biochim Biophys Acta, 1803, 872, 10.1016/j.bbamcr.2010.04.007