Inhibiting Vasculogenesis After Radiation: A New Paradigm to Improve Local Control by Radiotherapy

Egeblad, 2010, Tumors as organs: Complex tissues that interface with the entire organism, Dev Cell, 18, 884, 10.1016/j.devcel.2010.05.012 Reinhold, 1968, Tumour cure rate and cell survival of a transplantable rat rhabdomyosarcoma following x-irradiation, Eur J Cancer, 4, 367, 10.1016/0014-2964(68)90026-1 Baumann, 1990, Response of human squamous cell carcinoma xenografts of different sizes to irradiation: Relationship of clonogenic cells, cellular radiation sensitivity in vivo, and tumor rescuing units, Radiat Res, 123, 325, 10.2307/3577740 Gerweck, 1994, Multivariate determinants of radiocurability. I: Prediction of single fraction tumor control doses, Int J Radiat Oncol Biol Phys, 29, 57, 10.1016/0360-3016(94)90226-7 Taghian, 1993, Intrinsic radiation sensitivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme, Int J Radiat Oncol Biol Phys, 25, 243, 10.1016/0360-3016(93)90345-V Denekamp, 1984, Vascular endothelium as the vulnerable element in tumours, Acta Radiol Oncol, 23, 217, 10.3109/02841868409136015 Budach, 1993, Impact of stromal sensitivity on radiation response of tumors, J Natl Cancer Inst, 85, 988, 10.1093/jnci/85.12.988 Biedermann, 1991, SCID mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair, Proc Natl Acad Sci U S A, 88, 1394, 10.1073/pnas.88.4.1394 Shinohara, 2005, DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs, Cancer Res, 65, 4987, 10.1158/0008-5472.CAN-04-4250 Asahara, 1997, Isolation of putative progenitor endothelial cells for angiogenesis, Science, 275, 964, 10.1126/science.275.5302.964 Kawamoto, 2008, Endothelial progenitor cells for cardiovascular regeneration, Trends Cardiovasc Med, 18, 33, 10.1016/j.tcm.2007.11.004 Ahn, 2008, Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells, Cancer Cell, 13, 193, 10.1016/j.ccr.2007.11.032 Kioi, 2010, Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice, J Clin Invest, 120, 694, 10.1172/JCI40283 Gothert, 2004, Genetically tagging endothelial cells in vivo: Bone marrow-derived cells do not contribute to tumor endothelium, Blood, 104, 1769, 10.1182/blood-2003-11-3952 Purhonen, 2008, Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth, Proc Natl Acad Sci U S A, 105, 6620, 10.1073/pnas.0710516105 Kozin, 2010, Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation, Cancer Res, 70, 5679, 10.1158/0008-5472.CAN-09-4446 Hillebrands, 2002, Bone marrow does not contribute substantially to endothelial-cell replacement in transplant arteriosclerosis, Nat Med, 8, 194, 10.1038/nm0302-194 Aicher, 2007, Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia, Circ Res, 100, 581, 10.1161/01.RES.0000259562.63718.35 Rehman, 2003, Peripheral blood endothelial progenitor cells are derived from monocyte/macrophages and secrete angiogenic growth factors, Circulation, 107, 1164, 10.1161/01.CIR.0000058702.69484.A0 Rohde, 2006, Blood monocytes mimic endothelial progenitor cells, Stem Cells, 24, 357, 10.1634/stemcells.2005-0072 Awad, 2006, Differential healing activities of CD34+ and CD14+ endothelial cell progenitors, Arterioscler Thromb Vasc Biol, 26, 758, 10.1161/01.ATV.0000203513.29227.6f Ahn, 2010, Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment, Proc Natl Acad Sci U S A, 107, 8363, 10.1073/pnas.0911378107 Chen, 2009, Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors, Clin Cancer Res, 15, 1721, 10.1158/1078-0432.CCR-08-1471 DeNardo, 2011, Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy, Cancer Discov, 1, 54, 10.1158/2159-8274.CD-10-0028 Welford, 2011, TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice, J Clin Invest, 10.1172/JCI44562 Shojaei, 2007, Tumor refractoriness to anti-VEGF treatment is mediated by CD11b(+)Gr1(+) myeloid cells, Nat Biotechnol, 25, 911, 10.1038/nbt1323 Prionas, 1990, Effects of X irradiation on angiogenesis, Radiat Res, 124, 43, 10.2307/3577692 Imaizumi, 2010, Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting, PLoS One, 5, e11084, 10.1371/journal.pone.0011084 Udagawa, 2007, Chronic suppression of angiogenesis following radiation exposure is independent of hematopoietic reconstitution, Cancer Res, 67, 2040, 10.1158/0008-5472.CAN-06-2877 Garcia-Barros, 2003, Tumor response to radiotherapy regulated by endothelial cell apoptosis, Science, 300, 1155, 10.1126/science.1082504 Park, 2012, Radiation-induced vascular damage in tumors: Implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS), Radiat Res, 177, 311, 10.1667/RR2773.1 Takahashi, 1999, Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization, Nat Med, 5, 434, 10.1038/8462 Orlic, 2001, Bone marrow cells regenerate infarcted myocardium, Nature, 410, 701, 10.1038/35070587 Lyden, 1999, Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts, Nature, 401, 670, 10.1038/44334 Lyden, 2001, Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth, Nat Med, 7, 1194, 10.1038/nm1101-1194 Aghi, 2005, Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors, Mol Ther, 12, 994, 10.1016/j.ymthe.2005.07.693 De Palma, 2006, Role of haematopoietic cells and endothelial progenitors in tumour angiogenesis, Biochim Biophys Acta, 1766, 159 Grunewald, 2006, VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells, Cell, 124, 175, 10.1016/j.cell.2005.10.036 Ceradini, 2004, Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1, Nat Med, 10, 858, 10.1038/nm1075 Du, 2008, HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion, Cancer Cell, 13, 206, 10.1016/j.ccr.2008.01.034 Williams, 2005, Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1, Radiother Oncol, 75, 89, 10.1016/j.radonc.2005.01.009 Moeller, 2004, Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules, Cancer Cell, 5, 429, 10.1016/S1535-6108(04)00115-1 Wang, 2006, Evidence for ischemia induced host-derived bone marrow cell mobilization into cardiac allografts, J Mol Cell Cardiol, 41, 478, 10.1016/j.yjmcc.2006.06.074 Jin, 2006, Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes, Nat Med, 12, 557, 10.1038/nm1400 Aghi, 2006, Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes, Cancer Res, 66, 9054, 10.1158/0008-5472.CAN-05-3759 Grunewald, 2006, VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells, Cell, 124, 175, 10.1016/j.cell.2005.10.036 De Clercq, 2009, The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil), Biochem Pharmacol, 77, 1655, 10.1016/j.bcp.2008.12.014 Miao, 2007, CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature, Proc Natl Acad Sci U S A, 104, 15735, 10.1073/pnas.0610444104 Jang, 2006, Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea, Am J Pathol, 168, 1676, 10.2353/ajpath.2006.050400 Sayyed, 2009, Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes, Diabetologia, 52, 2445, 10.1007/s00125-009-1493-6 Liu SC, Alomran R, Quan F, et al: Inhibition of SDF-1 (CXCL12) using the Spiegelmer NOX-A12 markedly delays the recurrence of ENU-induced rats brain tumors following irradiation. AACR 2012 Annual Meeting. 2012; Abstract #4382.