Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Cell - Tập 162 Số 5 - Trang 974-986 - 2015
Katherine B. Chiappinelli1, Pamela L. Strissel2, Alexis Desrichard3, Huili Li1, Christine Henke2, Benjamin Akman1, Alexander Hein2, Neal S. Rote4, Leslie Cope1, Alexandra Snyder5,3, Vladimir Makarov3, Sadna Buhu5, Dennis J. Slamon6, Jedd D. Wolchok5, Drew M. Pardoll1, Matthias W. Beckmann2, Cynthia A. Zahnow1, Taha Merghoub5, Timothy A. Chan5,3, Stephen B. Baylin1, Reiner Strick2
1Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA
2Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University-Clinic Erlangen, 91054 Erlangen, Germany
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
4Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH 44106, USA
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065 USA
6The Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA 90095, USA

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