Infraorbital cutaneous angiosarcoma: a diagnostic and therapeutic dilemma

Springer Science and Business Media LLC - Tập 4 - Trang 1-5 - 2008
Tobias Ettl1, Johannes Kleinheinz2, Ravi Mehrotra3, Stephan Schwarz4, Torsten E Reichert1, Oliver Driemel1
1Department of Oral and Maxillofacial Surgery, Regensburg University, Germany
2Department of Oral and Maxillofacial Surgery, Muenster University, Germany
3Department of Pathology, Moti Lal Nehru Medical College, Allahabad University, India
4Department of Pathology, Erlangen University, Germany

Tóm tắt

A cutaneous angiosarcoma is a rare malignant tumour of vascular endothelial cells with aggressive clinical behaviour and poor prognosis. Diagnosis is often delayed due to its variable and often benign clinical appearance. This case presents a 64-year-old man with a six-month-history of a recurrent diffuse and erythematous painless swelling below the left eye. Several resections with intraoperatively negative resection margins followed, but positive margins were repeatedly detected later on permanent sections. Histopathologic examination of the specimen diagnosed a cutaneous angiosarcoma. Neither, finally achieved negative margins on permanent sections, nor a following chemotherapy could prevent the recurrence of the disease after five months and the patient's dead 21 months after the first diagnosis. The case elucidates the current diagnostic and therapeutic dilemma of this entity, which shows an unfavourable clinical course in spite of multimodal therapy.

Tài liệu tham khảo

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