Influenza vaccine responses in older adults

Ageing Research Reviews - Tập 10 - Trang 379-388 - 2011
Janet E. McElhaney1,2
1Department of Medicine, University of British Columbia, Vancouver, Canada
2Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT, USA

Tài liệu tham khảo

Acosta-Rodriguez, 2007, Interleukins 1b and 6 but not transforming growth factor-b are essential for the differentiation of interleukin 17-producing human T helper cells, Nat. Immunol., 8, 942, 10.1038/ni1496 Ahmed, 1995, Reduction in mortality associated with influenza vaccine during 1989–90 epidemic, Lancet, 346, 591, 10.1016/S0140-6736(95)91434-X Almanzar, 2005, Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons, J. Virol., 79, 3675, 10.1128/JVI.79.6.3675-3683.2005 Anon., 2009, Update: novel influenza A (H1N1) virus infections—worldwide, May 6, 2009, MMWR, 58, 453 Anon., 2009, Outbreaks of 2009 pandemic influenza A (H1N1) among long-term—care facility residents—three states, MMWR, 59, 74 Anon., 2010, Licensure of a high-dose inactivated influenza vaccine for persons aged > or =65 years (Fluzone High-Dose) and guidance for use—United States, 2010, MMWR, 59, 485 Askonas, 1982, Cytotoxic T-memory cells in virus infection and the specificity of helper T cells, Immunology, 45, 79 Aspinall, 2008, Reversal of age-associated thymic atrophy: treatments, delivery, and side effects, Exp. Gerontol., 43, 700, 10.1016/j.exger.2008.04.014 Aspinall, 2007, Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination, Rejuvenation Res., 10, 5, 10.1089/rej.2006.9098 Atmar, 2009, Adjuvants for pandemic influenza vaccines, Curr. Top. Microbiol. Immunol., 333, 323, 10.1007/978-3-540-92165-3_16 Barker, 1998, A study of the impact of influenza on the functional status of frail older people, Arch. Intern. Med., 158, 645, 10.1001/archinte.158.6.645 Baxter, 2010, Evidence of bias in studies of influenza vaccine effectiveness in elderly patients, J. Infect. Dis., 201, 186, 10.1086/649568 Belshe, 2004, Serum antibody responses after intradermal vaccination against influenza, N. Engl. J. Med., 351, 2286, 10.1056/NEJMoa043555 Benacerraf, 1981, Role of MHC gene products in immune regulation, Science, 212, 1229, 10.1126/science.6165083 Bernstein, 1999, Immune response to influenza vaccination in a large healthy elderly population, Vaccine, 17, 82, 10.1016/S0264-410X(98)00117-0 Boon, 2002, Influenza A virus specific T cell immunity in humans during aging, Virology, 299, 100, 10.1006/viro.2002.1491 Boon, 2010, Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 influenza mouse model, J. Virol., 84, 7662, 10.1128/JVI.02444-09 Butchko, 1978, Specificity studies on the proliferative response of thymus-derived lymphocytes to influenza viruses, J. Immunol., 121, 2381, 10.4049/jimmunol.121.6.2381 Chi, 2010, Immunogenicity and safety of intradermal influenza vaccination in healthy older adults, Clin. Infect. Dis., 50, 1331, 10.1086/652144 Co, 2009, In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses, Vaccine, 27, 319, 10.1016/j.vaccine.2008.09.092 Corti, 2010, Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine, J. Clin. Invest., 120, 1663, 10.1172/JCI41902 Cox, 2004, Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines, Scand. J. Immunol., 59, 1, 10.1111/j.0300-9475.2004.01382.x Czesnikiewicz-Guzik, 2008, T cell subset-specific susceptibility to aging, Clin. Immunol., 127, 107, 10.1016/j.clim.2007.12.002 Darmon, 1995, Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B, Nature, 377, 446, 10.1038/377446a0 de Bruijn, 1997, Annually repeated influenza vaccination improves humoral responses to several influenza virus strains in healthy elderly, Vaccine, 15, 1323, 10.1016/S0264-410X(97)00019-4 de Bruijn, 1999, Quality and quantity of the humoral immune response in healthy elderly and young subjects after annually repeated influenza vaccination, J. Infect. Dis., 179, 31, 10.1086/314540 de Bruijn, 2006, The virosomal influenza vaccine Invivac((R)): immunogenicity and tolerability compared to an adjuvanted influenza vaccine (Fluad((R))) in elderly subjects, Vaccine, 24, 6629, 10.1016/j.vaccine.2006.05.035 de Bruijn, 2007, Antibody induction by virosomal. MF59-adjuvanted, or conventional influenza vaccines in the elderly, Vaccine, 26, 119, 10.1016/j.vaccine.2007.10.051 Demotz, 1990, The minimal number of class II MHC-antigen complexes needed for T cell activation, Science, 249, 1028, 10.1126/science.2118680 Dixit, 2007, Ghrelin promotes thymopoiesis during aging, J. Clin. Invest., 117, 2778, 10.1172/JCI30248 Dixit, 2009, Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression: implications for age-associated increases in inflammation, Blood, 113, 5202, 10.1182/blood-2008-09-181255 Effros, 2007, Role of T lymphocyte replicative senescence in vaccine efficacy, Vaccine, 25, 599, 10.1016/j.vaccine.2006.08.032 Effros, 1977, Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses, J. Exp. Med., 145, 557, 10.1084/jem.145.3.557 Effros, 2005, The role of CD8+ T-cell replicative senescence in human aging, Immunol. Rev., 205, 147, 10.1111/j.0105-2896.2005.00259.x Ellebedy, A., Ducatez, M., Duan, S., Stigger-Rosser, E., Rubrum, A., Webb, A., Griffin, Y., DeBeauchamp, J., Webster, R., Govorkova, E., McElhaney, J., Webby, R., submitted for publication. Role of age and seasonal vaccination in protection from pandemic H1N1 2009 influenza virus. Ennis, 1981, HLA restricted virus-specific cytotoxic T-lymphocyte responses to live and inactivated influenza vaccines, Lancet, 2, 887, 10.1016/S0140-6736(81)91389-1 Ewen, 2003, A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B, J. Immunol. Methods, 276, 89, 10.1016/S0022-1759(03)00073-5 Falsey, 2005, Respiratory syncytial virus infection in elderly and high-risk adults, N. Engl. J. Med., 352, 1749, 10.1056/NEJMoa043951 Falsey, 2009, Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older, J. Infect. Dis., 200, 172, 10.1086/599790 Ferrucci, 1997, Hospital diagnoses Medicare charges, and nursing home admissions in the year when older persons become severely disabled [see comments], JAMA, 277, 728, 10.1001/jama.277.9.728 Fireman, 2009, Influenza vaccination and mortality: differentiating vaccine effects from bias, Am. J. Epidemiol., 170, 650, 10.1093/aje/kwp173 Franceschi, 2000, Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space, Vaccine, 18, 1717, 10.1016/S0264-410X(99)00513-7 Galli, 2009, Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels, Proc. Natl. Acad. Sci. U. S. A., 106, 3877, 10.1073/pnas.0813390106 Gardner, 2002, Age-related changes in Type 1 and Type 2 cytokine production in humans, Biogerontology, 3, 271, 10.1023/A:1020151401826 Gardner, 2001, Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population, Vaccine, 19, 4610, 10.1016/S0264-410X(01)00246-8 Gijzen, 2010, Standardization and validation of assays determining cellular immune responses against influenza, Vaccine, 28, 3416, 10.1016/j.vaccine.2010.02.076 Glezen, 2000, Impact of respiratory virus infections on persons with chronic underlying conditions, JAMA, 283, 499, 10.1001/jama.283.4.499 Goronzy, 2001, Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals, J. Virol., 75, 12182, 10.1128/JVI.75.24.12182-12187.2001 Gorse, 2003, Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study, Vaccine, 21, 2133, 10.1016/S0264-410X(02)00748-X Gorse, 2004, Immunity to influenza in older adults with chronic obstructive pulmonary disease, J. Infect. Dis., 190, 11, 10.1086/421121 Govaert, 1994, The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial, JAMA, 272, 1661, 10.1001/jama.272.21.1661 Govaert, 1994, Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial, Vaccine, 12, 1185, 10.1016/0264-410X(94)90241-0 Hackett, 1990, Virus entry and antigen biosynthesis in the processing and presentation of class-II MHC-restricted T-cell determinants of influenza virus, Immunol. Res., 9, 103, 10.1007/BF02918201 Hackett, 1991, Class II MHC-restricted T cell determinants processed from either endosomes or the cytosol show similar requirements for host protein transport but different kinetics of presentation, J. Immunol., 146, 2944, 10.4049/jimmunol.146.9.2944 Hak, 2006, Benefits of influenza vaccine in US elderly—appreciating issues of confounding bias and precision, Int. J. Epidemiol., 35, 800, 10.1093/ije/dyl068 Haynes, 2004, Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo, J. Immunol., 172, 5194, 10.4049/jimmunol.172.9.5194 Holland, 2008, Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial, J. Infect. Dis., 198, 650, 10.1086/590434 Hosaka, 1988, Recognition of noninfectious influenza virus by class I-restricted murine cytotoxic T lymphocytes, J. Immunol., 140, 606, 10.4049/jimmunol.140.2.606 Jackson, 2006, Evidence of bias in estimates of influenza vaccine effectiveness in seniors, Int. J. Epidemiol., 35, 337, 10.1093/ije/dyi274 Jackson, 2006, Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors, Int. J. Epidemiol., 35, 345, 10.1093/ije/dyi275 Jackson, 2008, Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study, Lancet, 372, 398, 10.1016/S0140-6736(08)61160-5 Jansen, 2008, Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program, Vaccine, 26, 5567, 10.1016/j.vaccine.2008.08.003 Jegerlehner, 2004, Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity, J. Immunol., 172, 5598, 10.4049/jimmunol.172.9.5598 Johnson, 2003, Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice, Proc. Natl. Acad. Sci. U. S. A., 100, 2657, 10.1073/pnas.0538056100 Kaech, 2003, Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells, Nat. Immunol., 4, 1191, 10.1038/ni1009 Kang, 2004, Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine, J. Immunol., 173, 673, 10.4049/jimmunol.173.1.673 Keitel, 1988, Efficacy of sequential annual vaccination with inactivated influenza virus vaccine, Am. J. Epidemiol., 127, 353, 10.1093/oxfordjournals.aje.a114809 Khader, 2007, IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge, Nat. Immunol., 8, 369, 10.1038/ni1449 Lamb, 1991, Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus, Proc. Natl. Acad. Sci. U. S. A., 88, 5998, 10.1073/pnas.88.14.5998 Laurence, 2007, TH-17 differentiation: of mice and men, Nat. Immunol., 8, 903, 10.1038/ni0907-903 Lawrence, 2005, Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection, J. Immunol., 174, 5332, 10.4049/jimmunol.174.9.5332 Leng, 2007, Inflammation and frailty in older women, J. Am. Geriatr. Soc., 55, 864, 10.1111/j.1532-5415.2007.01186.x Leroux-Roels, 2009, Humoral and cellular immune responses to split-virion H5N1 influenza vaccine in young and elderly adults, Vaccine, 27, 6918, 10.1016/j.vaccine.2009.08.110 Louie, 2009, Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California, JAMA, 302, 1896, 10.1001/jama.2009.1583 Maue, 2009, Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells, J. Immunol., 182, 6129, 10.4049/jimmunol.0804226 McElhaney, 2009, Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response, Expert Rev. Vaccines, 8, 593, 10.1586/erv.09.12 McElhaney, 2009, Immunosenescence: what does it mean to health outcomes in older adults?, Curr. Opin. Immunol., 21, 418, 10.1016/j.coi.2009.05.023 McElhaney, 1996, The cell-mediated cytotoxic response to influenza vaccination using an assay for granzyme B activity, J. Immunol. Methods, 190, 11, 10.1016/0022-1759(95)00235-9 McElhaney, 1998, Immune response to influenza vaccination in institutionalized elderly: effect on different T-cell subsets, Vaccine, 16, 403, 10.1016/S0264-410X(97)80918-8 McElhaney, 1998, Responses to influenza vaccination in different T-cell subsets: a comparison of healthy young and older adults, Vaccine, 16, 1742, 10.1016/S0264-410X(98)00133-9 McElhaney, 2001, Granzyme B: a marker of risk for influenza in institutionalized older adults, Vaccine, 19, 3744, 10.1016/S0264-410X(01)00087-1 McElhaney, 2006, T cell responses are better correlates of vaccine protection in the elderly, J. Immunol., 176, 6333, 10.4049/jimmunol.176.10.6333 McElhaney, 2009, Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults, Vaccine, 27, 2418, 10.1016/j.vaccine.2009.01.136 McMichael, 1983, Cytotoxic T-cell immunity to influenza, N. Engl. J. Med., 309, 13, 10.1056/NEJM198307073090103 McMichael, 1983, Declining T-cell immunity to influenza, 1977-82, Lancet, 2, 762, 10.1016/S0140-6736(83)92297-3 Min, 2002, Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation, Blood, 99, 4592, 10.1182/blood.V99.12.4592 Min, 2007, Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging, Blood, 109, 2529, 10.1182/blood-2006-08-043794 Mitchell, 1983, Fine specificity of the in vitro antibody response to influenza virus by human blood lymphocytes, J. Immunol., 131, 1229, 10.4049/jimmunol.131.3.1229 Monto, 2009, Influenza control in the 21st century: optimizing protection of older adults, Vaccine, 27, 5043, 10.1016/j.vaccine.2009.06.032 Monto, 2009, Comparative efficacy of inactivated and live attenuated influenza vaccines, N. Engl. J. Med., 361, 1260, 10.1056/NEJMoa0808652 Mosmann, 1986, Two types of murine helper T cell clone I. Definition according to profiles of lymphokine activities and secreted proteins, J. Immunol., 136, 2348, 10.4049/jimmunol.136.7.2348 Murasko, 2002, Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly, Exp. Gerontol., 37, 427, 10.1016/S0531-5565(01)00210-8 Nelson, 2009, New strategies are needed to improve the accuracy of influenza vaccine effectiveness estimates among seniors, J. Clin. Epidemiol., 62, 687, 10.1016/j.jclinepi.2008.06.014 Nguyen, 1999, Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8(+) cytotoxic T lymphocyte responses induced in mucosa-associated tissues, Virology, 254, 50, 10.1006/viro.1998.9521 Nichol, 2009, Challenges in evaluating influenza vaccine effectiveness and the mortality benefits controversy, Vaccine, 27, 6305, 10.1016/j.vaccine.2009.07.006 Nichol, 1994, The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community, N. Engl. J. Med., 331, 778, 10.1056/NEJM199409223311206 Nichol, 2003, Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly, N. Engl. J. Med., 348, 1322, 10.1056/NEJMoa025028 Nichol, 2007, Effectiveness of influenza vaccine in the community-dwelling elderly, N. Engl. J. Med., 357, 1373, 10.1056/NEJMoa070844 Okuno, 1993, A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains, J. Virol., 67, 2552, 10.1128/JVI.67.5.2552-2558.1993 Ouyang, 2003, Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1), Exp. Gerontol., 38, 911, 10.1016/S0531-5565(03)00134-7 Ouyang, 2003, Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old, J. Clin. Immunol., 23, 247, 10.1023/A:1024580531705 Palladino, 1991, Activity of CD4+ T-cell clones of type 1 and type 2 in generation of influenza virus-specific cytotoxic responses in vitro, J. Virol., 65, 6071, 10.1128/JVI.65.11.6071-6076.1991 Panda, 2010, Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response, J. Immunol., 184, 2518, 10.4049/jimmunol.0901022 Pawelec, 2004, Is immunosenescence infectious?, Trends Immunol., 25, 406, 10.1016/j.it.2004.05.006 Ray, 2004, The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection, Immunity, 20, 167, 10.1016/S1074-7613(04)00021-4 Reichert, 2004, Influenza and the winter increase in mortality in the United States, 1959–1999, Am. J. Epidemiol., 160, 492, 10.1093/aje/kwh227 Renshaw, 2002, Cutting edge: impaired Toll-like receptor expression and function in aging, J. Immunol., 169, 4697, 10.4049/jimmunol.169.9.4697 Rock, 2005, Cross-presentation: underlying mechanisms and role of immune surveillance, Immunol. Rev., 207, 166, 10.1111/j.0105-2896.2005.00301.x Russell, 1979, T cells primed by influenza virion internal components can cooperate in the antibody response to haemagglutinin, Nature, 280, 147, 10.1038/280147a0 Saurwein-Teissl, 2002, Lack of antibody production following immunization in old age: association with CD8(+)CD28(−) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines, J. Immunol., 168, 5893, 10.4049/jimmunol.168.11.5893 Scherle, 1988, Differential ability of B cells specific for external vs. internal influenza virus proteins to respond to help from influenza virus-specific T-cell clones in vivo, Proc. Natl. Acad. Sci. U. S. A., 85, 4446, 10.1073/pnas.85.12.4446 Simonsen, 2007, Mortality benefits of influenza vaccination in elderly people, an ongoing controversy, Lancet Infect. Dis., 7, 658, 10.1016/S1473-3099(07)70236-0 Simonsen, 2009, Influenza vaccination and mortality benefits: new insights, new opportunities, Vaccine, 27, 6300, 10.1016/j.vaccine.2009.07.008 Skowronski, 2008, Rapid decline of influenza vaccine-induced antibody in the elderly: is it real, or is it relevant?, J. Infect. Dis., 197, 490, 10.1086/524146 Stout-Delgado, 2009, Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection, Cell Host Microbe, 6, 446, 10.1016/j.chom.2009.09.011 Sui, 2009, Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses, Nat. Struct. Mol. Biol., 16, 265, 10.1038/nsmb.1566 Sullivan, 2010, Advances in the vaccination of the elderly against influenza: role of a high-dose vaccine, Expert Rev. Vaccines, 9, 1127, 10.1586/erv.10.117 Thomas, 2006, Cell-mediated protection in influenza infection, Emerg. Infect. Dis., 12, 48, 10.3201/eid1201.051237 Thompson, 2003, Mortality associated with influenza and respiratory syncytial virus in the United States, JAMA, 289, 179, 10.1001/jama.289.2.179 Thompson, 2004, Influenza-associated hospitalizations in the United States, JAMA, 292, 1333, 10.1001/jama.292.11.1333 Throsby, 2008, Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells, PLoS One, 3, e3942, 10.1371/journal.pone.0003942 Valenzuela, 2002, Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus, Clin. Immunol., 105, 117, 10.1006/clim.2002.5271 van Duin, 2007, Toll-like receptors in older adults, J. Am. Geriatr. Soc., 55, 1438, 10.1111/j.1532-5415.2007.01300.x Vescovini, 2007, Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects, J. Immunol., 179, 4283, 10.4049/jimmunol.179.6.4283 Voordouw, 2004, Annual revaccination against influenza and mortality risk in community-dwelling elderly persons, JAMA, 292, 2089, 10.1001/jama.292.17.2089 Vu, 2002, A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community, Vaccine, 20, 1831, 10.1016/S0264-410X(02)00041-5