Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

Cell Host & Microbe - Tập 5 Số 5 - Trang 439-449 - 2009
Michaela U. Gack1,2,3, Randy A. Albrecht4, Tomohiko Urano5,6, Kyung-Soo Inn1,2, I‐Chueh Huang1, Elena Carnero4, Michael Farzan1, Satoshi Inoue5,6, Jae U. Jung1,2, Adolfo Garcı́a-Sastre7,4,8
1Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772, USA
2Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J. Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
3Institute for Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany
4Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
5Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan
6Research Center for Genomic Medicine, Saitama Medical School, Saitama 350-124-2, Japan
7Department of Medicine, Division of Infectious Diseases, One Gustave L. Levy Place, New York, NY 10029, USA
8Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA

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