Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs
Tóm tắt
The purpose of the present study was to evaluate the influence of different surface characteristics on bone integration of titanium implants. Hollow‐cylinder implants with six different surfaces were placed in the metaphyses of the tibia and femur in six miniature pigs. After 3 and 6 weeks, the implants with surrounding bone were removed and analyzed in undecalcified transverse sections. The histologic examination revealed direct bone‐implant contact for all implants. However, the morphometric analyses demonstrated significant differences in the percentage of bone‐implant contact, when measured in cancellous bone. Electropolished as well as the sandblasted and acid pickled (medium grit; HF/HNO3) implant surfaces had the lowest percentage of bone contact with mean values ranging between 20 and 25%. Sandblasted implants with a large grit and titanium plasmasprayed implants demonstrated 30–40% mean bone contact. The highest extent of bone‐implant interface was observed in sandblasted and acid attacked surfaces (large grit; HCl/H2SO4) with mean values of 50–60%, and hydroxylapatite (HA)‐coated implants with 60–70%. However, the HA coating consistently revealed signs of resorption. It can be concluded that the extent of bone‐implant interface is positively correlated with an increasing roughness of the implant surface.
Từ khóa
Tài liệu tham khảo
Brånemark P. I., 1977, Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10‐year period, Scand. J. Plast. Reconstr. Surg.
Schroeder A., 1976, Gewebereaktion auf ein Titan‐ Hohlzylinderimplantat mit Titan‐Spritzschichtoberfläche, Schweiz. Mschr. Zahnheilk., 86, 713
Schroeder A., 1978, Über die Anlagerung von Osteozement an einen belasteten Implantatkörper, Schweiz. Mschr. Zahnheilk., 88, 1051
Kirsch A., 1984, Tierexperimentelle Untersuchungen zur Bedeutung der Mikromorphologie von Titanimplantatoberflächen, Fortschr. Zahnärztl. Implantol., 1, 35
Pillar R. M., 1987, Porous‐surfaced metallic implants for orthopedic applications, J. Biomed. Mater. Res., 21, 1
Steinemann S. G., 1986, Advances in Biomaterials, Vol. 6: Biological and Biomechanical Performances of Biomaterials, 409
Strunz V., 1983, Morphometrische Untersuchungen über den Knochenkontakt an titanplasmabeschichteten Implantaten, Fortschr. Kiefer Gesichtschir., 28, 47
Schroeder A., 1991, Oral Implantology
Block M. S., 1989, Loaded hydroxylapatite‐coated and grit‐blasted titanium implants in dogs, Int. J. Oral Maxillofac. Implants., 4, 219
Denissen H. W., 1990, Mandibular bone response to plasma‐sprayed coatings of hydroxy‐apatite, Int. J. Prosth., 3, 53
Wilke H. J., 1990, Advances in Biomaterials, Vol. 9: Clinical Implant Materials, 309
Schenk R. K., 1984, Methods of Calcified Tissue Preparation, 1
Schenk R. K., 1980, Handbuch der inneren Medizin VI/IA: Knochen, Gelenke, Muskeln, 437
Schenk R. K., 1987, Fracture Healing, 23
S.Steinemann personal communication (1990).