Influence of overweight and obesity on perinatal outcomes in assisted reproduction: a retrospective cohort study

Springer Science and Business Media LLC - Tập 22 Số 1 - 2022
Victória Campos Dornelles1,2, Marta Ribeiro Hentschke1,2, M Badalotti1,2, Isadora Badalotti-Teloken1,2, Vanessa Devens Trindade1,2, Bibiana Cunegatto1, Natália Fontoura Vasconcelos1,2, Álvaro Petracco1, Bartira Ercília Pinheiro da Costa2, Alexandre Vontobel Padoin2
1Fertilitat - Reproductive Medicine Center, Rua Gomes Jardim, 201 Torre Norte 15° andar, Porto Alegre, Brazil
2School of Medicine, Pontifical Catholic University of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil

Tóm tắt

AbstractBackgroundIn spontaneous pregnancies, maternal weight and gestational diabetes are independent risk factors for macrosomia and large-for-gestational-age newborns. Furthermore, maternal body mass index (BMI) of ≥25 kg/m2is associated with worse neonatal vitality, classified as an Apgar score of < 7 at the fifth minute of life. However, few studies have evaluated the influence of BMI on perinatal outcomes in pregnancies resulting from assisted reproduction. Therefore, this study aimed to analyze whether the perinatal outcomes of assisted reproduction are influenced by BMI.MethodsThis was a retrospective cohort study performed at a reproductive medicine center. Patients undergoing assisted reproduction (2013–2020) were divided into three groups according to their BMI (kg/m2): group 1, < 25; group 2, 25–29.9, and group 3, ≥30. In total, 1753 in vitro fertilization embryo transfer cycles were analyzed. Data were expressed as mean ± standard deviation or frequency (%). The analysis of variance and chi-square test were performed for comparison. To determine the participants and number of cycles for these analyses, generalized estimating equations were used, consideringp < 0.05.ResultsIn groups 1, 2, and 3, the rates of live birth were 33.5, 32.3, and 29.9% (p = 0.668); preeclampsia were 2.9, 6.1, and 6.3% (p = 0.268); small-for-gestational-age newborns were 23, 23.2, and 21.7% (p = 0.965); macrosomia were 1.9, 0.9, and 2.7% (p = 0.708); Apgar score > 7 at the fifth minute were 97.6, 98.2, and 100% (p = 0.616); and preterm birth were 29.6, 30.1, and 35.1% (p = 0.970), respectively.ConclusionsIn conclusion, although the three groups had similar perinatal outcomes in this study, the study population was too small for conclusive results. The higher the BMI, the lower the chances of clinically relevant LBR and the higher the chances of premature labor and preeclampsia.

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