Influence of ezetimibe on ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion

Boger, 1998, Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia, Circulation, 98, 1842, 10.1161/01.CIR.98.18.1842 Bulut, 2005, Endothelial function in the forearm circulation of patients with the metabolic syndrome – effect of different lipid-lowering regimens, Cardiology, 104, 176, 10.1159/000088105 Cardounel, 2007, Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function, J Biol Chem, 282, 879, 10.1074/jbc.M603606200 Chobanyan, 2007, J Chromatogr B Analyt Technol Biomed Life Sci, 858, 32, 10.1016/j.jchromb.2007.08.002 Dice, 1979, Protein degradation in metabolic and nutritional disorders, Ciba Found Symp, 75, 331 Dimitrow, 2007, Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy, Pharmacol Rep, 59, 715 Fan, 1999, Therapeutic approaches for ischemia/reperfusion injury in the liver, J Mol Med, 77, 577, 10.1007/s001099900029 Fukuda, 2010, Ezetimibe ameliorates cardiovascular complications and hepatic steatosis in obese and type 2 diabetic db/db mice, J Pharmacol Exp Ther, 335, 70, 10.1124/jpet.110.170373 Furchgott, 1996, The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor its importance in the identification of nitric oxide, JAMA, 276, 1186, 10.1001/jama.276.14.1186 Garcia-Cavlo, 2005, The target of ezetimibe is Niemann-Pick C 1–Like 1 (NPC1L1), Proc Natl Acad Sci USA, 102, 8132, 10.1073/pnas.0500269102 Hines, 2005, Endothelial nitric oxide synthase protects the post-ischemic liver: potential interactions with superoxide, Biomed Pharmacother, 59, 183, 10.1016/j.biopha.2005.03.011 Hornig, 1998, Plasma levels of ADMA are increased and inversely related to endothelium-mediated vasodilation in patients with chronic heart failure: a new predictor of endothelial dysfunction?, Circulation, 98, 318 Jehlicka, 2009, Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1, Physiol Res, 58, 179, 10.33549/physiolres.931418 Laleman, 2005, A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis, Hepatology, 42, 1382, 10.1002/hep.20968 Landmesser, 2005, Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans, Circulation, 111, 2356, 10.1161/01.CIR.0000164260.82417.3F Leiper, 2002, S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase, Proc Natl Acad Sci USA, 99, 13527, 10.1073/pnas.212269799 Leiper, 1999, Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases, Biochem J, 343, 209, 10.1042/0264-6021:3430209 Leiper, 1999, Biological significance of endogenous methylarginines that inhibit nitric oxide synthases, Cardiovasc Res, 43, 542, 10.1016/S0008-6363(99)00162-5 Lhuillier, 2003, Hepatic ischemia is associated with an increase in liver parenchyma nitric oxide that is in part enzyme-independent, Anesthesiology, 98, 373, 10.1097/00000542-200302000-00017 Lin, 2002, Impaired nitric oxide sythase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase, Circulation, 106, 987, 10.1161/01.CIR.0000027109.14149.67 Lluch, 2004, Plasma concentrations of nitric oxide and asymmetric dimethylarginine in human alcoholic cirrhosis, J Hepatol, 41, 55, 10.1016/j.jhep.2004.03.016 Maas, 2005, Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA), Vasc Med, 10, S49, 10.1177/1358836X0501000108 Martin-Sanz, 2003, Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function, Liver Transpl, 9, 40, 10.1053/jlts.2003.50008 Matsuguma, 2006, Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease, J Am Soc Nephrol, 17, 2176, 10.1681/ASN.2005121379 Miranda, 2010, Effects of partial liver ischemia followed by global liver reperfusion on the remote tissue expression of nitric oxide synthase: lungs and kidneys, Transplant Proc, 42, 1557, 10.1016/j.transproceed.2010.02.097 Mishima, 2004, Expression of DDAH1 in chick and rat embryos, Brain Res Dev Brain Res, 148, 223, 10.1016/j.devbrainres.2003.09.021 Mookerjee, 2005, Decreased hepatic extraction of asymmetric and symmetric dimethylarginine (ADMA/SDMA-NOS inhibitors) in acute alcoholic hepatitis may contribute to impaired end-organ function, Hepatology, 42, 419A Morales, 2006, Effect of quercetin on metallothionein, nitric oxide synthase and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats, Toxicol Appl Pharmacol, 210, 128, 10.1016/j.taap.2005.09.006 Nakagami, 2009, Vascular protective effects of ezetimibe in ApoE-deficient mice, Atherosclerosis, 203, 51, 10.1016/j.atherosclerosis.2008.05.026 Nakamura, 2009, Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner, Pharmacol Res, 60, 525, 10.1016/j.phrs.2009.04.011 Nijveldt, 2003, The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA), Clin Nutr, 22, 17, 10.1054/clnu.2002.0612 Parker, 2003, Influence of 3- hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors on endothelial nitric oxide synthase and the formation of oxidants in the vasculature, Atherosclerosis, 169, 19, 10.1016/S0021-9150(03)00100-X Peralta, 2001, Endogenous nitric oxide and exogenous nitric oxide supplementation in hepatic ischemia-reperfusion injury in the rat, Transplantation, 71, 529, 10.1097/00007890-200102270-00008 Perez, 2005, Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid, J Hepatol, 43, 324, 10.1016/j.jhep.2005.02.028 Scalera, 2004, Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence, Arterioscler Thromb Vasc Biol, 24, 1816, 10.1161/01.ATV.0000141843.77133.fc Schemmer, 1999, Reperfusion injury in livers due to gentle in situ organ manipulation during harvest involves hypoxia and free radicals, J Pharmacol Exp Ther, 290, 235 Shah, 1997, Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids, J Clin Invest, 100, 2923, 10.1172/JCI119842 Shah, 1999, Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat, Gastroenterology, 117, 1222, 10.1016/S0016-5085(99)70408-7 Stuhlinger, 2001, Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine, Circulation, 104, 2569, 10.1161/hc4601.098514 Sudhop, 2002, Cholesterol absorption inhibitors for the treatment of hypercholesterolemia, Drugs, 62, 2333, 10.2165/00003495-200262160-00002 Suchy, 2011, Ezetimibe – a new approach in hypercholesterolemia management, Pharmacol Rep, 63, 1335, 10.1016/S1734-1140(11)70698-3 Sydow, 2003, ADMA and oxidative stress, Atheroscler Suppl, 4, 41, 10.1016/S1567-5688(03)00033-3 Tran, 2003, The DDAH/ADMA/NOS pathway, Atheroscler Suppl, 4, 33, 10.1016/S1567-5688(03)00032-1 Trocha, 2010, Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver, Pharmacol Rep, 62, 343, 10.1016/S1734-1140(10)70274-7 Trocha, 2010, Asymmetric dimethylarginine synthesis and degradation under physiological and pathological conditions, Adv Clin Exp Med, 19, 223 Ueda, 2003, Regulation of cytokineinduced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase, Circ Res, 92, 226, 10.1161/01.RES.0000052990.68216.EF Vallance, 2004, Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway, Arterioscler Thromb Vasc Biol, 24, 1023, 10.1161/01.ATV.0000128897.54893.26 Van de Casteele, 2002, In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats, Gut, 51, 440, 10.1136/gut.51.3.440 Xiong, 2003, Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin- induced diabetes, J Cardiovasc Pharmacol, 42, 191, 10.1097/00005344-200308000-00006 Xue, 2010, Protective effects of HGF-MSP chimer (metron factor-1) on liver ischemia-reperfusion injury in rat model, J Dig Dis, 11, 299, 10.1111/j.1751-2980.2010.00453.x