Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus

Amir, 1999, Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2, Nature Genetics, 23, 185, 10.1038/13810 Anderson, 2012, Sex and rearing condition modify the effects of perinatal lead exposure on learning and memory, Neurotoxicology, 33, 985, 10.1016/j.neuro.2012.04.016 Bestor, 2000, The DNA methyltransferases of mammals, Human Molecular Genetics, 9, 2395, 10.1093/hmg/9.16.2395 Bihaqi, 2011, Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease, Journal of Alzheimer's Disease, 27, 819, 10.3233/JAD-2011-111013 Bouchard, 2009, Blood lead levels and major depressive disorder, panic disorder, and generalized anxiety disorder in US young adults, Archives of General Psychiatry, 66, 1313, 10.1001/archgenpsychiatry.2009.164 Braga, 1999, Lead increases tetrodotoxin-insensitive spontaneous release of glutamate and GABA from hippocampal neurons, Brain Research, 826, 10, 10.1016/S0006-8993(99)01193-2 Cecil, 2008, Decreased brain volume in adults with childhood lead exposure, PLoS Med, 5, e112, 10.1371/journal.pmed.0050112 Cory-Slechta, 2004, Maternal stress modulates the effects of developmental lead exposure, Environmental Health Perspectives, 112, 717, 10.1289/ehp.6481 Cottrell, 2009, Prenatal stress, glucocorticoids and the programming of adult disease, Frontiers in Behavioral Neuroscience, 3, 19, 10.3389/neuro.08.019.2009 Davis, 1990, U-shaped dose-response curves: their occurrence and implications for risk assessment, Journal of Toxicology and Environmental Health, 30, 71, 10.1080/15287399009531412 Fan, 2001, DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals, Journal of Neuroscience, 21, 788, 10.1523/JNEUROSCI.21-03-00788.2001 Feng, 2005, Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system, Journal of Neuroscience Research, 79, 734, 10.1002/jnr.20404 Feng, 2007, Epigenetic regulation of neural gene expression and neuronal function, Pediatric Research, 61, 58R, 10.1203/pdr.0b013e3180457635 Feng, 2010, Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons, Nature Neuroscience, 13, 423, 10.1038/nn.2514 Golshani, 2005, Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation, Thalamus and Related Systems, 3, 227, 10.1017/S1472928807000222 Goto, 1994, Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice, Differentiation, 56, 39, 10.1046/j.1432-0436.1994.56120039.x Guilarte, 1998, Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure, Brain Research, 790, 98, 10.1016/S0006-8993(98)00054-7 Gupta, 2010, Histone methylation regulates memory formation, Journal of Neuroscience, 30, 3589, 10.1523/JNEUROSCI.3732-09.2010 Hanna, 2012, DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF, Human Reproduction, 27, 1401, 10.1093/humrep/des038 Hsiang, 2011, Lead and developmental neurotoxicity of the central nervous system, Current Neurobiology, 2, 8 Johnston, 2001, Neurobiology of Rett syndrome: a genetic disorder of synapse development, Brain and Development, 23, S206, 10.1016/S0387-7604(01)00351-5 Lanphear, 2005, Low-level environmental lead exposure and children's intellectual function: an international pooled analysis, Environmental Health Perspectives, 113, 894, 10.1289/ehp.7688 Lasley, 2002, Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure level, Toxicological Sciences, 66, 139, 10.1093/toxsci/66.1.139 Levenson, 2007, DNA (cytosine-5) methyltransferase inhibitors: a potential therapeutic agent for schizophrenia, Molecular Pharmacology, 71, 635, 10.1124/mol.106.033266 Levenson, 2004, Regulation of histone acetylation during memory formation in the hippocampus, Journal of Biological Chemistry, 279, 40545, 10.1074/jbc.M402229200 Levenson, 2006, Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus, Journal of Biological Chemistry, 281, 15763, 10.1074/jbc.M511767200 Liu, 2010, A study of the influence of sex on genome wide methylation, PLoS One, 5, e10028, 10.1371/journal.pone.0010028 Markovac, 1988, Picomolar concentrations of lead stimulate brain protein kinase C, Nature, 334, 71, 10.1038/334071a0 Mazumdar, 2011, Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study, Environmental Health, 10, 24, 10.1186/1476-069X-10-24 Miller, 2007, Covalent modification of DNA regulates memory formation, Neuron, 53, 857, 10.1016/j.neuron.2007.02.022 Mullaney, 2004, Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain, Neuroscience, 123, 939, 10.1016/j.neuroscience.2003.11.025 Nagarajan, 2006, Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation, Epigenetics, 1, e1, 10.4161/epi.1.4.3514 Nigg, 2010, Confirmation and extension of association of blood lead with attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels, Journal of Child Psychology and Psychiatry and Allied Disciplines, 51, 58, 10.1111/j.1469-7610.2009.02135.x Pelka, 2006, Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice, Brain, 129, 887, 10.1093/brain/awl022 Pilsner, 2009, Influence of prenatal lead exposure on genomic methylation of cord blood DNA, Environmental Health Perspectives, 117, 1466, 10.1289/ehp.0800497 Qureshi, 2010, Genetic and epigenetic underpinnings of sex differences in the brain and in neurological and psychiatric disease susceptibility, Progress in Brain Research, 186, 77, 10.1016/B978-0-444-53630-3.00006-3 Robertson, 2000, DNA methylation in health and disease, Nature Reviews Genetics, 1, 11, 10.1038/35049533 Schneider, 2011, Sex-based differences in gene expression in hippocampus following postnatal lead exposure, Toxicology and Applied Pharmacology, 256, 179, 10.1016/j.taap.2011.08.008 Schneider, 2012, Effects of developmental lead exposure on the hippocampal transcriptome: influences of sex, developmental period, and lead exposure level, Toxicological Sciences, 129, 108, 10.1093/toxsci/kfs189 Schneider, 2012, Differential effect of postnatal lead exposure on gene expression in the hippocampus and frontal cortex, Journal of Molecular Neuroscience, 47, 76, 10.1007/s12031-011-9686-0 Surkan, 2007, Neuropsychological function in children with blood lead levels <10 microg/dL, Neurotoxicology, 28, 1170, 10.1016/j.neuro.2007.07.007 White, 2007, New and evolving concepts in the neurotoxicology of lead, Toxicology and Applied Pharmacology, 225, 1, 10.1016/j.taap.2007.08.001 Wright, 2010, Biomarkers of lead exposure and DNA methylation within retrotransposons, Environmental Health Perspectives, 118, 790, 10.1289/ehp.0901429 Yasui, 2007, Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes, Proceedings of the National Academy of Sciences of the United States of America, 104, 19416, 10.1073/pnas.0707442104 Yuan, 2006, The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function, Pediatrics, 118, 971, 10.1542/peds.2006-0467 Zaiser, 1997, Prenatal and postnatal chronic exposure to low levels of inorganic lead attenuates long-term potentiation in the adult rat hippocampus in vivo, Neuroscience Letters, 239, 128, 10.1016/S0304-3940(97)00895-1