Influence of Dietary Fatty Acids on Cytokine Production and Its Clinical Implications

Nutrition in Clinical Practice - Tập 8 Số 2 - Trang 65-72 - 1993
Simin Nikbin Meydani1, Charles A. Dinarello2
1Nutritional Immunology Laboratory, USDA-Human Nutrition Research Center on Aging at Tufts University
2Department of Medicine, Tufts University–New England Medical Center, Boston

Tóm tắt

Cytokines and eicosanoids are important biologic mediators with tightly regulated production. Overproduction contributes to pathogenesis of chronic and acute inflammatory, autoimmune, atherosclerotic, and neoplastic diseases. Animal and human studies have shown that production of cytokines and eicosanoids can be reduced by certain dietary fatty acids, specifically those containing long‐chain (n‐3) polyunsaturated fatty acids (PUFAs). This in turn results in reduction of the severity of certain autoimmune, inflammatory, and atherosclerotic diseases. Because these cytokines are also involved in control of the host defense, substantial reduction in their production could also result in the impairment of normal immune response. Increased intake of (n‐3) PUFAs without adequate antioxidant protection could result in increased free radical formation and lipid peroxidation. Thus, when (n‐3) PUFAs are used to reduce the pathogenesis of these diseases, its possible adverse effects should be considered and prevented.

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Tài liệu tham khảo

10.1056/NEJM198505093121909

Herold PM, 1986, Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials, Am J Clin Nutr, 43, 566, 10.1093/ajcn/43.4.566

10.1056/NEJM198505093121901

10.7326/0003-4819-106-4-497

10.7326/0003-4819-116-8-609

10.1056/NEJM198904203201603

Akira S., 1990, Biology of multifunctional cytokines: IL6 and related molecules (IL1 and TNF), FASEB J, 4, 2860, 10.1096/fasebj.4.11.2199284

Dinarello CA, 1989, Biology of interleukin 1, FASEB J, 2, 108, 10.1096/fasebj.2.2.3277884

Knusden PJ, 1986, Prostaglandins posttranscriptionally inhibit monocyte expression ofinterleukin 1 activity by increasing intracellular cyclic adenosine monophosphate, J Immunol, 137, 3189, 10.4049/jimmunol.137.10.3189

10.1056/NEJM198702123160705

10.1126/science.1411569

10.1111/j.1749-6632.1990.tb00177.x

Miller RA, 1989, The cell biology of aging: immunological models, Age, 44, B4

10.1038/262401a0

10.1084/jem.155.3.943

Billar TR, 1988, Fatty acid intake and Kupffer cell function: fish oil alters eicosanoid and monokine production to endotoxin stimulation, Surgery, 104, 343

10.1016/0165-2478(90)90073-Y

10.1016/0167-4889(91)90098-I

10.1016/0952-3278(91)90161-W

Meydani SN, 1992, Immunological effects of NCEP‐Step 2 diets: effects of n‐3 fatty acids [Abstract], FASEB J, 6, A1370

Meydani SN, 1991, Oral (n‐3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women, J Nutr, 121, 547, 10.1093/jn/121.4.547

10.1056/NEJM198902023200501

10.1016/0090-1229(89)90177-3

Santoli D., 1989, Prostaglandin E precursor fatty acids inhibit human IL‐2 production by a prostaglandin E‐dependent mechanism, Immunology, 143, 1303

Kramer TR, 1991, Increased vitamin E intake restores fish‐oil‐induced suppressed blastogenesis of mitogenic‐stimulated Tlymphocytes, AmJ ClinNutr, 54, 896

Kelly DS, 1991, Dietary ‐linolic acid and immunocompetence in humans, Am J Clin Nutr, 53, 40, 10.1093/ajcn/53.1.40

Payan DG, 1983, Specific suppression of human T lymphocyte function by leukotriene B4, J Immunol, 131, 551, 10.4049/jimmunol.131.2.551

10.1002/art.1780260203

Kelly VE, 1985, A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites and suppresses lupus in MRL‐1pr mice, J Immunol, 134, 1914, 10.4049/jimmunol.134.3.1914

10.1084/jem.162.4.1336

Prickett JD, 1982, Dietary fish oil augments the induction of arthritis in rats immunized with type II collagen, J Immunol, 132, 725, 10.4049/jimmunol.132.2.725

Prickett JD, 1982, Enhanced production of IgE and IgG antibodies associated with a diet enriched in eicosanpentaenoic acid, Immunology, 46, 819

10.1002/art.1780330607

Darlington LG, 1987, Olive oil for rheumatoid patients?, Br J Dermatol, 26, 129

10.1111/1523-1747.ep12505715

Fogh K., 1990, Lipoxygenase products of arachidonic acid in psoriasis, atopic dermatitis, and experimental arthritis, Dan Med Bull, 37, 289

10.1111/1523-1747.ep12505675

10.1016/S0140-6736(86)91502-3

10.1073/pnas.84.7.1940

10.1016/S0140-6736(89)91682-6

Ziboh VA, 1986, Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids. Modulation of clinical course of psoriatic subjects, Arch Dermatol, 122, 1277, 10.1001/archderm.1986.01660230069013

10.1016/S0140-6736(88)91181-6

10.1097/00004836-199004000-00009

Lorenz R., 1989, Supplementation with n‐3 fatty acids from fish oil in chronic inflammatory bowel disease: a randomized, placebo‐controlled, double‐blind cross‐over trial, J Intern Med, 225, 223

Fujikawa M., 1992, Eicosapentaenoic acid inhibits antigen‐presenting cell function of murine splenocytes, Immunology, 75, 330

Hubbard NE, 1991, Effect of dietary fish oil on development and selected functions of murine inflammatory macrophages, J Leukocyte Biol, 49, 592, 10.1002/jlb.49.6.592

10.1016/0026-0495(92)90181-9

Berdanier CD, 1992, Life span is shortened in BHE/cdb rats fed a diet containing 9% menhaden oil and 1% corn oil, J Nutr, 122, 1309, 10.1093/jn/122.6.1309

D'Ambola JB, 1991, Effect of dietary (n‐3) and (n‐6) fatty acids on in vivo pulmonary bacterial clearance by neonatal rabbits, J Nutr, 121, 1262, 10.1093/jn/121.8.1262

Lee TK, 1985, The effect of a fish‐oil‐enriched diet on pulmonary mechanics during anaphylaxis, Am Rev Respir Dis, 132, 1204

Hu M‐L., 1989, Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates, J Nutr, 119, 1574, 10.1093/jn/119.11.1574

10.1042/bst0150410

10.1007/BF02535232

L'Abbe MR, 1991, Dietary (n‐3) fatty acids affect rat heart, liver and aorta protective enzyme activities and lipid peroxidation, J Nutr, 121, 1331, 10.1093/jn/121.9.1331

Halliwell B., 1987, Oxidants and human disease: some new concepts, FASEB J, 1, 358, 10.1096/fasebj.1.5.2824268

10.1016/0891-5849(91)90174-2

Witting LA, 1974, Vitamin E‐polyunsaturated lipid relationship in diet and tissues, Am J Clin Nutr, 27, 952, 10.1093/ajcn/27.9.952

Horwitt MK, 1976, Vitamin E: Reexamination, Am J Clin Nutr, 29, 5, 10.1093/ajcn/29.5.569

10.1007/BF02534004

10.1016/0021-9150(91)90107-E

Meydani M., 1991, Effect of long‐term fish oil supplementation on vitamin E status and lipid peroxidation in women, J Nutr, 121, 484, 10.1093/jn/121.4.484