Inflammation in osteoarthritis

Heinegard, 2011, The role of the cartilage matrix in osteoarthritis., Nat Rev Rheumatol, 7, 50, 10.1038/nrrheum.2010.198

Goldring, 2011, Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis., Eur Cell Mater, 21, 202, 10.22203/eCM.v021a16

Little, 2010, Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis: insights from studies of aggrecan and collagen proteolysis Curr Drug T, argets, 11, 561

Van den Berg, 2011, Osteoarthritis year 2010 in review: pathomechanisms., Osteoarthritis Cartilage, 19, 338, 10.1016/j.joca.2011.01.022

Sellam, 2010, The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis., Nat Rev Rheumatol, 6, 625, 10.1038/nrrheum.2010.159

Pozgan, 2010, Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis., Biol Chem, 391, 571, 10.1515/bc.2010.035

Scanzello, 2011, Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms., Arthritis Rheum, 63, 391, 10.1002/art.30137

Catterall, 2010, Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)., Arthritis Res Ther, 12, R229, 10.1186/ar3216

Lotz, 2010, New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options., Arthritis Res Ther, 12, 211, 10.1186/ar3046

Gobezie, 2007, High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis., Arthritis Res Ther, 9, R36, 10.1186/ar2172

Ding, 2010, Mechanical impact induces cartilage degradation via mitogen activated protein kinases., Osteoarthritis Cartilage, 18, 1509, 10.1016/j.joca.2010.08.014

Goodwin, 2010, Rotenone prevents impact-induced chondrocyte death., J Orthop Res, 28, 1057, 10.1002/jor.21091

Torzilli, 2010, Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage., Osteoarthritis Cartilage, 18, 97, 10.1016/j.joca.2009.07.012

Xu, 2010, Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice., Arthritis Rheum, 62, 2736, 10.1002/art.27582

Polur, 2010, Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration., Histol Histopathol, 25, 599

Echtermeyer, 2009, Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis., Nat Med, 15, 1072, 10.1038/nm.1998

Matsui, 2009, Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice., Arthritis Rheum, 60, 2362, 10.1002/art.24705

Happonen, 2010, Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis., Arthritis Rheum, 62, 3574, 10.1002/art.27720

Song, 2007, Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5., Arthritis Rheum, 56, 575, 10.1002/art.22334

Rogerson, 2010, Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice., Arthritis Rheum, 62, 3365, 10.1002/art.27661

Gabay, 2010, Stigmasterol: a phytosterol with potential antiosteoarthritic properties., Osteoarthritis Cartilage, 18, 106, 10.1016/j.joca.2009.08.019

Marcu, 2010, NF-kappaB signaling: multiple angles to target OA., Curr Drug Targets, 11, 599, 10.2174/138945010791011938

Liu, 2010, Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes., Arthritis Res Ther, 12, R167, 10.1186/ar3127

Nishitani, 2010, PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes., J Cell Biochem, 109, 425, 10.1002/jcb.22421

Long, 2010, p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation., Osteoarthritis Cartilage, 18, 1203, 10.1016/j.joca.2010.05.016

Yang, 2010, Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction., Nat Med, 16, 687, 10.1038/nm.2153

Tetsunaga, 2011, Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells., Osteoarthritis Cartilage, 19, 222, 10.1016/j.joca.2010.11.004

Thirunavukkarasu, 2006, Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines., Biochem Biophys Res Commun, 345, 197, 10.1016/j.bbrc.2006.04.023

Thirunavukkarasu, 2007, Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter., Mol Biol Rep, 34, 225, 10.1007/s11033-006-9037-3

Geurts, 2011, Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts., Rheumatology (Oxford), 50, 1216, 10.1093/rheumatology/ker021

Liu-Bryan, 2010, Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice., Arthritis Rheum, 62, 2004, 10.1002/art.27475

Campo, 2010, Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes., Biochimie, 92, 204, 10.1016/j.biochi.2009.10.006

Heinola, 2010, High mobility group box-1 (HMGB-1) in osteoarthritic cartilage., Clin Exp Rheumatol, 28, 511

Garcia-Arnandis, 2010, High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1beta in osteoarthritic synoviocytes., Arthritis Res Ther, 12, R165, 10.1186/ar3124

Miranda, 2010, Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13., J Biol Chem, 285, 31517, 10.1074/jbc.M110.125898

Kapoor, 2011, Role of proinflammatory cytokines in the pathophysiology of osteoarthritis., Nat Rev Rheumatol, 7, 33, 10.1038/nrrheum.2010.196

Rasheed, 2011, Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-kappaB in human osteoarthritis chondrocytes., Rheumatology (Oxford), 50, 838, 10.1093/rheumatology/keq380

Zreiqat, 2010, S100A8 and S100A9 in experimental osteoarthritis., Arthritis Res Ther, 12, R16, 10.1186/ar2917

Blanco, 2011, The role of mitochondria in osteoarthritis., Nat Rev Rheumatol, 7, 161, 10.1038/nrrheum.2010.213

Kim, 2010, Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes., Osteoarthritis Cartilage, 18, 424, 10.1016/j.joca.2009.09.008

Cillero-Pastor, 2010, Proteomic analysis by two-dimensional electrophoresis to identify the normal human chondrocyte proteome stimulated by tumor necrosis factor alpha and interleukin-1beta., Arthritis Rheum, 62, 802, 10.1002/art.27265

Cillero-Pastor, 2011, Effect of nitric oxide on mitochondrial activity of human synovial cells., BMC Musculoskelet Disord, 12, 42, 10.1186/1471-2474-12-42

Shane Anderson, 2010, Why is osteoarthritis an age-related disease Best Pract Res Clin R, heumatol, 24, 15

Loeser, 2010, Age-related changes in the musculoskeletal system and the development of osteoarthritis., Clin Geriatr Med, 26, 371, 10.1016/j.cger.2010.03.002

Carames, 2010, Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis., Arthritis Rheum, 62, 791, 10.1002/art.27305

Bohensky, 2009, Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy., Arthritis Rheum, 60, 1406, 10.1002/art.24444

Clockaerts, 2010, The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review., Osteoarthritis Cartilage, 18, 876, 10.1016/j.joca.2010.03.014

Conde, 2011, Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes., Ann Rheum Dis, 70, 551, 10.1136/ard.2010.132399

Kang, 2010, Adiponectin is a potential catabolic mediator in osteoarthritis cartilage., Arthritis Res Ther, 12, R231, 10.1186/ar3218

Zhang, 2010, Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization., Arthritis Rheum, 62, 1993, 10.1002/art.27473

Griffin, 2010, Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice., Arthritis Res Ther, 12, R130, 10.1186/ar3068

Imagawa, 2011, The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes: implications for osteoarthritis., Biochem Biophys Res Commun, 405, 362, 10.1016/j.bbrc.2011.01.007

De Andres, 2011, Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis., Biochem Biophys Res Commun, 407, 54, 10.1016/j.bbrc.2011.02.101

Chubinskaya, 2011, Regulation of chondrocyte gene expression by osteogenic protein-1., Arthritis Res Ther, 13, R55, 10.1186/ar3300

Araldi, 2010, MicroRNA-140 and the silencing of osteoarthritis., Genes Dev, 24, 1075, 10.1101/gad.1939310

Alcaraz, 2010, New molecular targets for the treatment of osteoarthritis., Biochem Pharmacol, 80, 13, 10.1016/j.bcp.2010.02.017

Kim, 2010, MicroRNA-221 regulates chondrogenic differentiation through promoting proteosomal degradation of slug by targeting Mdm2., J Biol Chem, 285, 26900, 10.1074/jbc.M110.115105

Miyaki, 2010, MicroRNA-140 plays dual roles in both cartilage development and homeostasis., Genes Dev, 24, 1173, 10.1101/gad.1915510

Li, 2011, MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis., Gene, 480, 34, 10.1016/j.gene.2011.03.003

Akhtar, 2010, MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes., Arthritis Rheum, 62, 1361, 10.1002/art.27329

Murata, 2010, Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis., Arthritis Res Ther, 12, R86, 10.1186/ar3013

Dudek, 2010, Type II collagen expression is re gulated by tissue-specific miR-675 in human articular chondrocytes., J Biol Chem, 285, 24381, 10.1074/jbc.M110.111328