Inflammation Promotes the Loss of Adeno-Associated Virus–Mediated Transgene Expression in Mouse Liver
Tài liệu tham khảo
Snyder, 1997, Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors, Nat Genet, 16, 270, 10.1038/ng0797-270
Mingozzi, 2003, Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer, J Clin Invest, 111, 1347, 10.1172/JCI200316887
Breous, 2009, Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver, Hepatology, 50, 612, 10.1002/hep.23043
Koeberl, 1997, Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors, Proc Natl Acad Sci U S A, 94, 1426, 10.1073/pnas.94.4.1426
Gao, 2009, Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses, Hum Gene Ther, 20, 930, 10.1089/hum.2009.060
Fischer, 2000, Chronic liver disease in heterozygous alpha1-antitrypsin deficiency PiZ, J Hepatol, 33, 883, 10.1016/S0168-8278(00)80119-1
Real, 2010, Circulating mononuclear cells nuclear factor-kappa B activity, plasma xanthine oxidase, and low grade inflammatory markers in adult patients with familial hypercholesterolaemia, Eur J Clin Invest, 40, 89, 10.1111/j.1365-2362.2009.02218.x
Ehl, 1998, Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology, J Exp Med, 187, 763, 10.1084/jem.187.5.763
Rocken, 1992, Infection breaks T-cell tolerance, Nature, 359, 79, 10.1038/359079a0
Bell, 2005, An optimized protocol for detection of E. coli beta-galactosidase in lung tissue following gene transfer, Histochem Cell Biol, 124, 77, 10.1007/s00418-005-0793-2
Kay, 2001, Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics, Nat Med, 7, 33, 10.1038/83324
Limberis, 2007, Activation of CFTR-specific T Cells in cystic fibrosis mice following gene transfer, Mol Ther, 15, 1694, 10.1038/sj.mt.6300210
Hoerr, 2000, In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies, Eur J Immunol, 30, 1, 10.1002/1521-4141(200001)30:1<1::AID-IMMU1>3.0.CO;2-#
Breous, 2009, Identification of the immunodominant cytotoxic T-cell epitope of human alpha-1 antitrypsin, Gene Ther, 16, 1380, 10.1038/gt.2009.100
Beutler, 2003, Innate immune sensing and its roots: the story of endotoxin, Nat Rev Immunol, 3, 169, 10.1038/nri1004
Raetz, 1990, Biochemistry of endotoxins, Annu Rev Biochem, 59, 129, 10.1146/annurev.bi.59.070190.001021
Lipford, 1997, CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants, Eur J Immunol, 27, 2340, 10.1002/eji.1830270931
Klinman, 1996, CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma, Proc Natl Acad Sci U S A, 93, 2879, 10.1073/pnas.93.7.2879
Lin, 2007, Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in mice, J Clin Invest, 117, 3958
Velazquez, 2009, Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy, Blood, 113, 538, 10.1182/blood-2008-01-131375
Cavanaugh, 1998, Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice, J Virol, 72, 2630, 10.1128/JVI.72.4.2630-2637.1998
Guidotti, 2001, Noncytolytic control of viral infections by the innate and adaptive immune response, Annu Rev Immunol, 19, 65, 10.1146/annurev.immunol.19.1.65
Tao, 2001, Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver, Mol Ther, 3, 28, 10.1006/mthe.2000.0227
Wang, 2010, Systematic evaluation of AAV vectors for liver directed gene transfer in murine models, Mol Ther, 18, 118, 10.1038/mt.2009.246
Solis-Herruzo, 1988, Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts, J Biol Chem, 263, 5841, 10.1016/S0021-9258(18)60642-8
Sung, 2001, TNFalpha and IFNgamma induced by innate anti-adenoviral immune responses inhibit adenovirus-mediated transgene expression, Mol Ther, 3, 757, 10.1006/mthe.2001.0318
Andus, 1988, Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins, Eur J Immunol, 18, 739, 10.1002/eji.1830180513
Wispe, 1990, Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein, J Clin Invest, 86, 1954, 10.1172/JCI114929
Rhee, 2011, Multiple innate immune pathways contribute to the immunogenicity of recombinant adenovirus vaccine vectors, J Virol, 85, 315, 10.1128/JVI.01597-10
Zhu, 2010, Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice, J Clin Invest, 120, 607, 10.1172/JCI39293
Warger, 2006, Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo, Blood, 108, 544, 10.1182/blood-2005-10-4015
Pasare, 2003, Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells, Science, 299, 1033, 10.1126/science.1078231
Urry, 2009, Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function, J Clin Invest, 119, 387
Peng, 2005, Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function, Science, 309, 1380, 10.1126/science.1113401
Mencin, 2009, Toll-like receptors as targets in chronic liver diseases, Gut, 58, 704, 10.1136/gut.2008.156307
Kanzler, 2007, Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists, Nat Med, 13, 552, 10.1038/nm1589