Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
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Baggio, 1998, Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors, FASEB J., 12, 433, 10.1096/fasebj.12.6.433
Bagnara, 2000, Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network, J. Gerontol. A: Biol. Sci. Med. Sci., 55, B61, 10.1093/gerona/55.2.B61
Balistreri, 2004, Role of Toll-like receptor 4 in acute myocardial infarction and longevity, JAMA, 292, 2339
Balistreri, 2005, Role of TLR4 receptor polymorphisms in Boutonneuse fever, Int. J. Immunopathol. Pharmacol., 18, 655, 10.1177/039463200501800406
Ballard, 2004, Differential fitness of mitochondrial DNA in perturbation cage studies correlates with global abundance and population history in Drosophila simulans, Proc. Biol. Sci., 271, 1197, 10.1098/rspb.2004.2709
Banks, 1995, Passage of cytokines across the blood-brain barrier, Neuroimmunomodulation, 2, 241, 10.1159/000097202
Barbieri, 2003, Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons, Am. J. Physiol. Endocrinol. Metab., 284, E481, 10.1152/ajpendo.00319.2002
Barbieri, 2003, Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans, Am. J. Physiol. Endocrinol. Metab., 285, E1064, 10.1152/ajpendo.00296.2003
Barbieri, 2005, Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors, Exp. Gerontol., 40, 599, 10.1016/j.exger.2005.05.004
Barker, 2004, The developmental origins of chronic adult disease, Acta Paediatr., 26, 10.1111/j.1651-2227.2004.tb00236.x
Barzilai, 2003, Unique lipoprotein phenotype and genotype associated with exceptional longevity, JAMA, 290, 2030, 10.1001/jama.290.15.2030
Bellizzi, 2006, Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines, Genes Cells, 11, 883, 10.1111/j.1365-2443.2006.00986.x
Bonafe, 2001, A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity, Eur. J. Immunol., 31, 2357, 10.1002/1521-4141(200108)31:8<2357::AID-IMMU2357>3.0.CO;2-X
Bonafe, 2002, Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians, Eur. J. Hum. Genet., 10, 292, 10.1038/sj.ejhg.5200806
Bonafe, 2003, Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control, J. Clin. Endocrinol. Metab., 88, 3299, 10.1210/jc.2002-021810
Bonafe, 2004, The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death, Cell Death Differ., 11, 962, 10.1038/sj.cdd.4401415
Bonfigli, 2004, Plasminogen activator inhibitor-1 plasma level increases with age in subjects with the 4G allele at position −675 in the promoter region, Thromb. Haemost., 92, 1164, 10.1055/s-0037-1614298
Bruunsgaard, 1999, A high plasma concentration of TNF-alpha is associated with dementia in centenarians, J. Gerontol. A: Biol. Sci. Med. Sci., 54, M357, 10.1093/gerona/54.7.M357
Candore, 2006, Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population, Ann. N. Y. Acad. Sci., 1067, 270, 10.1196/annals.1354.035
Capri, 2006, Complexity of anti-immunosenescence strategies in humans, Artif. Organs, 30, 730, 10.1111/j.1525-1594.2006.00295.x
Cardelli, 2006, A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity, J. Gerontol. A: Biol. Sci. Med. Sci., 61, 547, 10.1093/gerona/61.6.547
Carelli, 2003, Pathogenic expression of homoplasmic mtDNA mutations needs a complex nuclear-mitochondrial interaction, Trends Genet., 19, 257, 10.1016/S0168-9525(03)00072-6
Carelli, 2006, Haplogroup effects and recombination of mitochondrial DNA: novel clues from the analysis of Leber hereditary optic neuropathy pedigrees, Am. J. Hum. Genet., 78, 564, 10.1086/501236
Carrieri, 2001, Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease, Hum. Genet., 108, 194, 10.1007/s004390100463
Carrieri, 2004, The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians, Aging Cell, 3, 443, 10.1111/j.1474-9728.2004.00129.x
Caselli, 2006, Family clustering in Sardinian longevity: a genealogical approach, Exp. Gerontol., 41, 727, 10.1016/j.exger.2006.05.009
Cellini, 2005, Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians, Mech. Ageing Dev., 126, 826, 10.1016/j.mad.2005.01.009
Chen, 1990, Prolongation of the yeast life span by the v-Ha-RAS oncogene, Mol. Microbiol., 4, 2081, 10.1111/j.1365-2958.1990.tb00568.x
Christensen, 2006, The quest for genetic determinants of human longevity: challenges and insights, Nat. Rev. Genet., 7, 436, 10.1038/nrg1871
Christiansen, 2004, Paraoxonase 1 polymorphisms and survival, Eur. J. Hum. Genet., 12, 843, 10.1038/sj.ejhg.5201235
Christiansen, 2006, A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival, Mech. Ageing Dev., 127, 597, 10.1016/j.mad.2006.02.003
Cipriano, 2005, The −308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases, Int. J. Immunogenet., 32, 13, 10.1111/j.1744-313X.2005.00490.x
Clancy, 2001, Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein, Science, 292, 104, 10.1126/science.1057991
Conboy, 2005, Rejuvenation of aged progenitor cells by exposure to a young systemic environment, Nature, 433, 760, 10.1038/nature03260
Conboy, 2005, Aging, stem cells and tissue regeneration: lessons from muscle, Cell Cycle, 4, 407, 10.4161/cc.4.3.1518
Coppola, 2003, Von Willebrand factor in Italian centenarians, Haematologica, 88, 39
Damazo, 2006, Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis, J. Immunol., 176, 4410, 10.4049/jimmunol.176.7.4410
Dato, 2006, Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70 1 loci), Biogerontology
De Benedictis, 1997, DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus, Hum. Genet., 99, 312, 10.1007/s004390050364
De Benedictis, 1998, Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2), Eur. J. Hum. Genet., 6, 534, 10.1038/sj.ejhg.5200222
De Benedictis, 1999, Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans, FASEB J., 13, 1532, 10.1096/fasebj.13.12.1532
De Benedictis, 2006, The unusual genetics of human longevity, Sci. Aging Knowledge Environ., 10, pe20
de Magalhaes, 2005, Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations, Ageing Res. Rev., 4, 1, 10.1016/j.arr.2004.05.003
Elovitz, 2006, Elucidating the early signal transduction pathways leading to fetal brain injury in preterm birth, Pediatr. Res., 59, 50, 10.1203/01.pdr.0000191141.21932.b6
Ershler, 2000, Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty, Annu. Rev. Med., 51, 245, 10.1146/annurev.med.51.1.245
Evert, 2003, Morbidity profiles of centenarians: survivors, delayers, and escapers, J. Gerontol. A: Biol. Sci. Med. Sci., 58, 232, 10.1093/gerona/58.3.M232
Fagiolo, 1993, Increased cytokine production in mononuclear cells of healthy elderly people, Eur. J. Immunol., 23, 2375, 10.1002/eji.1830230950
Franceschi, 1992, Aging and cellular defense mechanisms, Ann. N. Y. Acad. Sci., 663
Franceschi, 2000, Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE), Aging (Milano), 12, 77
Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N. Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x
Franceschi, 2000, Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space, Vaccine, 18, 1717, 10.1016/S0264-410X(99)00513-7
Franceschi, 2003, Centenarians as a model for healthy aging, Biochem. Soc. Trans., 31, 457, 10.1042/bst0310457
Franceschi, 2005, Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians, Mech. Ageing Dev., 126, 351, 10.1016/j.mad.2004.08.028
Gangemi, 2003, Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?, Exp. Gerontol., 38, 669, 10.1016/S0531-5565(03)00061-5
Gangemi, 2005, Age-related modifications in circulating IL-15 levels in humans, Mediators Inflamm., 2005, 245, 10.1155/MI.2005.245
Giacconi, 2004, The −174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing, Exp. Gerontol., 39, 621, 10.1016/j.exger.2003.12.013
Gondo, 2006, Functional status of centenarians in Tokyo, Japan: developing better phenotypes of exceptional longevity, J. Gerontol. A: Biol. Sci. Med. Sci., 61, 305, 10.1093/gerona/61.3.305
Grimaldi, 2006, Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population, J. Leukoc. Biol., 79, 611, 10.1189/jlb.0705416
Hasty, 2003, Aging and genome maintenance: lessons from the mouse?, Science, 299, 1355, 10.1126/science.1079161
Hawkes, 2003, Grandmothers and the evolution of human longevity, Am. J. Human Biol., 15, 380, 10.1002/ajhb.10156
Hjelmborg, 2006, Genetic influence on human lifespan and longevity, Hum. Genet., 119, 312, 10.1007/s00439-006-0144-y
Jeune, 2006, Handgrip strength among nonagenarians and centenarians in three European regions, J. Gerontol. A: Biol. Sci. Med. Sci., 61, 707, 10.1093/gerona/61.7.707
Kim, 1999, Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae, Mol. Biol. Cell, 10, 3125, 10.1091/mbc.10.10.3125
Kivisild, 2006, The role of selection in the evolution of human mitochondrial genomes, Genetics, 172, 373, 10.1534/genetics.105.043901
Koch, 2006, Human cytomegalovirus infection and T cell immunosenescence: a mini review, Mech. Ageing Dev., 127, 538, 10.1016/j.mad.2006.01.011
Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309, 481, 10.1126/science.1112125
Lee, 2003, A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity, Nat. Genet., 33, 40, 10.1038/ng1056
Li, 2006, Transforming growth factor-beta regulation of immune responses, Annu. Rev. Immunol., 24, 99, 10.1146/annurev.immunol.24.021605.090737
Lin, 1997, daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans, Science, 278, 1319, 10.1126/science.278.5341.1319
Lin, 2001, Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling, Nat. Genet., 28, 139, 10.1038/88850
Lio, 2003, Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease, Genes Immun., 4, 234, 10.1038/sj.gene.6363964
Lio, 2002, Gender-specific association between -1082 IL-10 promoter polymorphism and longevity, Genes Immun., 3, 30, 10.1038/sj.gene.6363827
Listi, F., Candore, G., Grimaldi, M.P., Lio, D., Colonna-Romano, G., Orlando, V., Caruso, M., Hoffmann, E., Paolisso, G., Franceschi, C., Caruso, C. Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity. Biogerontology, in press [Epub ahead of print].
Mahley, 2006, Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A., 103, 5644, 10.1073/pnas.0600549103
Mannucci, 1997, Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians, Arterioscler. Thromb. Vasc. Biol., 17, 755, 10.1161/01.ATV.17.4.755
Marchegiani, 2006, Paraoxonase activity and genotype predispose to successful aging, J. Gerontol. A: Biol. Sci. Med. Sci., 61, 541, 10.1093/gerona/61.6.541
Mari, 1995, Hypercoagulability in centenarians: the paradox of successful aging, Blood, 85, 3144, 10.1182/blood.V85.11.3144.bloodjournal85113144
Migliaccio, 1999, The p66shc adaptor protein controls oxidative stress response and life span in mammals, Nature, 402, 309, 10.1038/46311
Mishmar, 2003, Natural selection shaped regional mtDNA variation in humans, Proc. Natl. Acad. Sci. U.S.A., 100, 171, 10.1073/pnas.0136972100
Moresi, 2005, Age- and gender-related alterations of the number and clonogenic capacity of circulating CD34+ progenitor cells, Biogerontology, 6, 185, 10.1007/s10522-005-7954-5
Mutus, 2000, Cellular resistance to homocysteine: a key for longevity, Atherosclerosis, 152, 527, 10.1016/S0021-9150(00)00546-3
Nanetti, 2005, Age-related changes on platelet membrane: a study on elderly and centenarian monozygotic twins, Exp. Gerontol., 40, 519, 10.1016/j.exger.2005.07.002
Neretti, N., Remondini, D., Tatar, M., Sedivy, J.M., Pierini, M., Mazzatti, D., Powell, J., Franceschi, C., Castellani, G.C. Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation, in press.
Niemi, 2005, A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects, Eur. J. Hum. Genet., 13, 166, 10.1038/sj.ejhg.5201308
Ogg, 1997, The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans, Nature, 389, 994, 10.1038/40194
Orr, 1993, Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster, Arch. Biochem. Biophys., 301, 34, 10.1006/abbi.1993.1111
Ottaviani, 1997, The invertebrate phagocytic immunocyte: clues to a common evolution of immune and neuroendocrine systems, Immunol. Today, 18, 169, 10.1016/S0167-5699(97)84663-4
Ottaviani, 1998, A new theory on the common evolutionary origin of natural immunity, inflammation and stress response: the invertebrate phagocytic immunocyte as an eye-witness, Domest. Anim. Endocrinol., 15, 291, 10.1016/S0739-7240(98)00021-6
Ouyang, 2003, Age-associated accumulation of CMV-specific CD8+T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1), Exp. Gerontol., 38, 911, 10.1016/S0531-5565(03)00134-7
Pancer, 2006, The evolution of adaptive immunity, Annu. Rev. Immunol., 24, 497, 10.1146/annurev.immunol.24.021605.090542
Passeri, 2003, Low vitamin D status, high bone turnover, and bone fractures in centenarians, J. Clin. Endocrinol. Metab., 88, 5109, 10.1210/jc.2003-030515
Pawelec, 2006, Human immunosenescence: does it have an infectious component?, Ann. N. Y. Acad. Sci., 1067, 56, 10.1196/annals.1354.009
Pennesi, 1999, TCR repertoire of suppressor CD8+CD28-T cell populations, Hum. Immunol., 60, 291, 10.1016/S0198-8859(98)00134-7
Perretti, 2006, Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor, Inflamm. Allergy Drug Targets, 5, 107, 10.2174/187152806776383170
Perretti, 2003, Annexin 1: an endogenous anti-inflammatory protein, News Physiol. Sci., 18, 60
Poulain, 2004, Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study, Exp. Gerontol., 39, 1423, 10.1016/j.exger.2004.06.016
Rabini, 2003, Evidence for reduction of pro-atherosclerotic properties in platelets from healthy centenarians, Exp. Gerontol., 38, 367, 10.1016/S0531-5565(02)00268-1
Rea, 2003, Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants, Mech. Ageing Dev., 124, 555, 10.1016/S0047-6374(03)00036-8
Rea, 2004, Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis, Exp. Gerontol., 39, 629, 10.1016/j.exger.2003.11.019
Reyes, 2005, Long-term consequences of low birth weight, Kidney Int., S107, 10.1111/j.1523-1755.2005.09718.x
Rose, 2001, Paradoxes in longevity: Sequence analysis of mtDNA haplogroup J in centenarians, Eur. J. Hum. Genet., 9, 701, 10.1038/sj.ejhg.5200703
Rose, 2003, Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly, Exp. Gerontol., 38, 1065, 10.1016/S0531-5565(03)00209-2
Roubertoux, 2003, Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice, Nat. Genet., 35, 65, 10.1038/ng1230
Ruiz-Pesini, 2004, Effects of purifying and adaptive selection on regional variation in human mtDNA, Science, 303, 223, 10.1126/science.1088434
Salvioli, 2005, p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1, Cell Cycle, 4, 1264, 10.4161/cc.4.9.1978
Salvioli, 2006, Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology, Curr. Pharm. Des., 12, 3161, 10.2174/138161206777947470
Santoro, 2006, Mitochondrial DNA involvement in human longevity, Biochim. Biophys. Acta, 1757, 1388, 10.1016/j.bbabio.2006.05.040
Schachter, 1994, Genetic associations with human longevity at the APOE and ACE loci, Nat. Genet., 6, 29, 10.1038/ng0194-29
Schoenmaker, 2006, Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study, Eur. J. Hum. Genet., 14, 79, 10.1038/sj.ejhg.5201508
Schmaltz, 2005, Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women, J. Am. Geriatr. Soc., 53, 747, 10.1111/j.1532-5415.2005.53250.x
Scola, 2005, Study of the association with −330T/G IL-2 in a population of centenarians from centre and south Italy, Biogerontology, 6, 425, 10.1007/s10522-005-4909-9
Smith, 2000, Apolipoprotein E4: an allele associated with many diseases, Ann. Med., 32, 118, 10.3109/07853890009011761
Taioli, 2001, Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus, Biochem. Biophys. Res. Commun., 280, 1389, 10.1006/bbrc.2001.4280
Terry, D.F., Wyszynski, D.F., Nolan, V.G., Atzmon, G., Schoenhofen, E.A., Pennington, J.Y., Andersen, S.L., Wilcox, M.A., Farrer, L.A., Barzilai, N., Baldwin, C.T., Asea, A. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mech. Ageing Dev., in press [Epub ahead of print].
Tieri, 2005, Quantifying the relevance of different mediators in the human immune cell network, Bioinformatics, 21, 1639, 10.1093/bioinformatics/bti239
Tissenbaum, 2001, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, Nature, 410, 227, 10.1038/35065638
Trifunovic, 2004, Premature ageing in mice expressing defective mitochondrial DNA polymerase, Nature, 429, 417, 10.1038/nature02517
Troiano, 1999, Evaluation of adrenal function in aging, J. Endocrinol. Invest., 22, 74
Turnbull, 1999, Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action, Physiol. Rev., 79, 1999
Tyner, 2002, p53 mutant mice that display early ageing-associated phenotypes, Nature, 415, 45, 10.1038/415045a
Vanfleteren, 1995, The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans, FASEB J., 9, 1355, 10.1096/fasebj.9.13.7557026
Vescovini, 2004, Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells, Exp. Gerontol., 39, 1233, 10.1016/j.exger.2004.04.004
Wack, 1998, Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets, Int. Immunol., 10, 1281, 10.1093/intimm/10.9.1281
Wikby, 2006, The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning, Mech. Ageing Dev., 127, 695, 10.1016/j.mad.2006.04.003
Williams, 1957, Pleiotropy, natural selection, and the evolution of senescence, Evolution, 11, 398, 10.1111/j.1558-5646.1957.tb02911.x
Zanni, 2003, Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence, Exp. Gerontol., 38, 981, 10.1016/S0531-5565(03)00160-8