Infiltration of M2 Macrophages and Regulatory T Cells Plays a Role in Recurrence of Renal Cell Carcinoma

Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 Wang, 2019, M2b macrophage polarization and its roles in diseases, J Leukoc Biol, 106, 345, 10.1002/JLB.3RU1018-378RR Murray, 2011, Obstacles and opportunities for understanding macrophage polarization, J Leukoc Biol, 89, 557, 10.1189/jlb.0710409 Erlandsson, 2019, M2 macrophages and regulatory T cells in lethal prostate cancer, Prostate, 79, 363, 10.1002/pros.23742 Yagi, 2019, Tumour-associated macrophages are associated with poor prognosis and programmed death ligand 1 expression in oesophageal cancer, Eur J Cancer, 111, 38, 10.1016/j.ejca.2019.01.018 Behnes, 2014, Tumor-associated macrophages are involved in tumor progression in papillary renal cell carcinoma, Virchows Arch, 464, 191, 10.1007/s00428-013-1523-0 Komohara, 2011, Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma, Cancer Sci, 102, 1424, 10.1111/j.1349-7006.2011.01945.x Ma, 2018, CD163-positive cancer cells are potentially associated with high malignant potential in clear cell renal cell carcinoma, Med Mol Morphol, 51, 13, 10.1007/s00795-017-0165-8 Nishikawa, 2005, CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients, Blood, 106, 1008, 10.1182/blood-2005-02-0607 Nishikawa, 2014, Regulatory T cells in cancer immunotherapy, Curr Opin Immunol, 27, 1, 10.1016/j.coi.2013.12.005 Hori, 2003, Control of regulatory T cell development by the transcription factor Foxp3, Science, 299, 1057, 10.1126/science.1079490 Davidsson, 2013, CD4 helper T cells, CD8 cytotoxic T cells, and FOXP3(+) regulatory T cells with respect to lethal prostate cancer, Mod Pathol, 26, 448, 10.1038/modpathol.2012.164 Peng, 2019, CD8(+) cytotoxic and FoxP3(+) regulatory T lymphocytes serve as prognostic factors in breast cancer, Am J Transl Res, 11, 5039 Shang, 2015, Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis, Sci Rep, 5, 15179, 10.1038/srep15179 Zhu, 2019, Profiles of tumor-infiltrating immune cells in renal cell carcinoma and their clinical implications, Oncol Lett, 18, 5235 Liotta, 2011, Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma, BJU Int, 107, 1500, 10.1111/j.1464-410X.2010.09555.x Griffiths, 2007, Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival, Cancer Immunol Immunother, 56, 1743, 10.1007/s00262-007-0318-z Siddiqui, 2007, Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma, Clin Cancer Res, 13, 2075, 10.1158/1078-0432.CCR-06-2139 Sun, 2017, A positive-feedback loop between tumour infiltrating activated Treg cells and type 2-skewed macrophages is essential for progression of laryngeal squamous cell carcinoma, Br J Cancer, 117, 1631, 10.1038/bjc.2017.329 Grabowska, 2018, Clinical outcome and time trends of surgically treated renal cell carcinoma between 1986 and 2010: results from a single centre in Sweden, Scand J Urol, 52, 206, 10.1080/21681805.2018.1430706 Hoshida, 2008, Gene expression in fixed tissues and outcome in hepatocellular carcinoma, N Engl J Med, 359, 1995, 10.1056/NEJMoa0804525 Han, 2016, CD163(+) M2-type tumor-associated macrophage support the suppression of tumor-infiltrating T cells in osteosarcoma, Int Immunopharmacol, 34, 101, 10.1016/j.intimp.2016.01.023 Liu, 2013, Modulation of macrophage activation and programming in immunity, J Cell Physiol, 228, 502, 10.1002/jcp.24157 Kubota, 2017, CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma, Sci Rep, 7, 1755, 10.1038/s41598-017-01661-z Zhu, 2016, Interaction between Treg cells and tumor-associated macrophages in the tumor microenvironment of epithelial ovarian cancer, Oncol Rep, 36, 3472, 10.3892/or.2016.5136 Dannenmann, 2013, Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell carcinoma, Oncoimmunology, 2, e23562, 10.4161/onci.23562 Smith-Bindman, 2019, Trends in use of medical imaging in US health care systems and in Ontario, Canada, 2000-2016, JAMA, 322, 843, 10.1001/jama.2019.11456 Rini, 2019, Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma, N Engl J Med, 380, 1116, 10.1056/NEJMoa1816714 Motzer, 2019, Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial, Lancet Oncol, 20, 1370, 10.1016/S1470-2045(19)30413-9