Inferring microstructural features and the physiological state of tissues from diffusion‐weighted images
Tóm tắt
We review several methods that have been developed to infer microstructural and physiological information about isotropic and anisotropic tissues from diffusion weighted images (DWIs). These include Diffusion Imaging (DI), Diffusion Tensor Imaging (DTI), isotropically weighted imaging, and q‐space imaging. Just as DI provides useful information about molecular displacements in one dimension with which to characterize diffusion in isotropic tissues, DTI provides information about molecular displacements in three dimensions needed to characterize diffusion is anisotropic tissues. DTI also furnishes scalar parameters that behave like quantitative histological or physiological‘stains’ for different features of diffusion. These include Trace(D), which is related to the mean diffusivity, and a family of parameters derived from the diffusion tensor, D, which characterize different features of anisotropic diffusion. Simple thought experiments and geometrical constructs, such as the diffusion ellipsoid, can be used to understand water diffusion in isotropic and anisotropic media, and the NMR experiments used to characterize it.
Từ khóa
Tài liệu tham khảo
Le Bihan D., 1985, Imagerie de diffusion in vivo par resonance magnetique nucleaire, Cr. Acad. Sci. (Paris), 301, 1109
Le Bihan D., 1991, Diffusion NMR imaging., Magn. Reson. Q., 7, 1
Le Bihan D., 1995, Diffusion and Perfusion Magnetic Resonance Imaging.
Basser P. J.Elucidating tissue structure and physiology via diffusion tensor MRI.J. Magn. Reson.(1996).
Crank J., 1975, The Mathematics of Diffusion
Le Bihan D., 1991, Molecular diffusion nuclear magnetic resonance imaging., Magn. Reson. Q., 7, 1
Basser P. J. Mattiello J.andLe Bihan D.Diagonal and off‐diagonal components of the self‐diffusion tensor: their relation to and estimation from the NMR spin‐echo signal.11th Annual Meeting of the SMRM.Abstr. p.1222(1992).
Mattiello J. Basser P. J.andLe Bihan D.Analytic expressions for the b‐matrix in diffusion tensor echo‐planar imaging.Magn. Reson. Med.(1995) (submitted).
Einstein A., 1926, Investigations on the Theory of the Brownian Movement.
Rao C. R., 1965, Linear Statistical Inference and its Applications.
Pierpaoli C. Mattiello J. Le Bihan D. DiChiro G.andBasser P. J.Diffusion tensor imaging of brain white matter anisotropy.13th Annual Meeting of the SMRM.Abstr. p.1038(1994).
Moseley M. E., 1990, Diffusion‐weighted MR imaging of acute stroke: correlation with T2‐weighted and magnetic susceptibility‐enhanced MR imaging in cats, Am. J. Neuroradiol., 11, 423
Chien D., 1992, MR diffusion imaging of cerebral infarction in humans., AJNR Am. J. Neuroradiol., 13, 1097
Basser P. J.andLe Bihan D.Fiber orientation mapping in an anisotropic medium with NMR diffusion spectroscopy.11th Annual Meeting of the SMRM.Abstr. p.1221(1992).
Basser P. J. Mattiello J. Turner R.andLe Bihan D.Diffusion tensor echo‐planar imaging of human brain 12th Annual Meeting of the SMRM.Abstr. p.1404(1993).
Basser P. J.Fiber orientation mapping in anisotropic media with NMR.BMES '92 Annual Conf.(1992).
Jezzard P.andPierpaoli C.Diffusion mapping using interleaved spin echo and STEAM EPI with navigator echo correction.SMR‐ESMRMB.Abstr. p.903(1995).
Pierpaoli C. Jezzard P.andBasser P.High‐resolution diffusion tensor imaging of the human brain.SMR‐ESMRMB.Abstr. p.899(1995).
Wong E. C.andCox R. W.Single‐shot imaging with isotropic diffusion weighting.2nd Annual Meeting of the SMR.Abstr. p.136(1994).
Basser P.andPierpaoli C.Elucidating tissue structure by diffusion tensor MRI.SMR‐ESMRMB.Abstr. p.900(1995).
Pierpaoli C.andBasser P. J.Toward a quantitative measure of diffusion anisotropy.Magn. Reson. Med.(1995) (submitted).
Yang Y. Shimony J. S. Xu S. Gulani V. Dawson M. J.andLauterbur P. C.A sequence for measurement of anisotropic diffusion by projection reconstructon imaging and its application to skeletal and smooth muscle.2nd Annual Meeting of the SMR.Abstr. P.1036(1994).
Pierpaoli C.andBasser P. J.New Invariant ‘Lattice’ Index Achieves Significant Noise Reduction in Measuring Diffusion AnisotropyProceedings of the ISMRM.Abstr. 1326(1996).
Le Grice I. J., 1995, Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dog., Am. J. Phys., 269, H571
Wedeen V. J. Reese T. G. Smith R. N.andRosen B. R.Mapping myocardial architecture with diffusion anisotropy MRI.Proc. SMR and ESMRMB.Abstr. p.357(1995).
Basser P. J. LeBihan D.andMattiello J.Measuring tissue fiber direction using diffusion NMR.37th Annual Meeting of the Biophysical Society.Abstr. p.131(1993).
Basser P. J. Mattiello J.andLeBihan D.MR imaging of fiber‐tract direction and diffusion in anisotropic tissues.12th Annual Meeting of the SMRM.Abstr. p.1403(1993).
Basser P. J. Mattiello J. Turner R.andLe Bihan D.Diffusion tensor echo‐planar imaging (DTEPI) of human brain.SMRM Workshop: Functional MRI of the Brain.Abstr. p.224(1993).
Davis T. L. Wedeen V. J. Weisskoff R. M.andRosen B. R.White matter tract visualization by echo‐planar MRI.SMRM 12th Annual Meeting.Abstr. p.289(1993).