Industrial R&D on Catalytic CC and CN Coupling Reactions: A Personal Account on Goals, Approaches and Results

Advanced Synthesis and Catalysis - Tập 346 Số 13-15 - Trang 1583-1598 - 2004
Hans‐Ulrich Blaser1, Adriano F. Indolese2, F. Naud1, Ulrike Nettekoven1, Anita Schnyder1
1Solvias AG, P. O. Box, 4002 Basel, Switzerland, Fax: (+41)‐61‐686‐6100
2Rohner AG, Gempenstr. 6, 4133 Pratteln, Switzerland

Tóm tắt

AbstractR&D issues for the application of Pd‐ and Ni‐catalyzed CC and CN coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of CC and CN coupling for preparative applications is described. The following principal approaches to industrial research are illustrated with relevant examples from the literature and from our own laboratories: i) development of catalysts and catalytic methodologies with industrial potential; ii) finding shorter routes to target molecules using catalytic methods; iii) development of industrial catalytic processes in multi‐step syntheses.

Từ khóa


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Advanced Synthesis and Catalysis

Tập 346 Số 13-15

1583-1598

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