Induction of genomic instability and activation of autophagy in artificial human aneuploid cells

Hernandez, 1999, Mouse autosomal trisomy: two’s company, three's a crowd, Trends Genet., 15, 241, 10.1016/S0168-9525(99)01743-6 Scott, 2006, Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour, J. Med. Genet., 43, 705, 10.1136/jmg.2006.041723 Khan, 2011, Myeloid leukemia in Down syndrome, Crit. Rev. Oncog., 16, 25, 10.1615/CritRevOncog.v16.i1-2.40 Ganmore, 2009, Constitutional aneuploidy and cancer predisposition, Hum. Mol. Genet., 18, R84, 10.1093/hmg/ddp084 Weaver, 2006, Does aneuploidy cause cancer?, Curr Opin. Cell Biol., 18, 658, 10.1016/j.ceb.2006.10.002 Hassold, 2001, To err (meiotically) is human: the genesis of human aneuploidy, Nat. Rev. Genet., 2, 280, 10.1038/35066065 Potapova, 2013, Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos, Cancer Metastasis Rev., 32, 377, 10.1007/s10555-013-9436-6 Pavelka, 2010, Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast, Nature, 468, 321, 10.1038/nature09529 Sheltzer, 2011, Aneuploidy drives genomic instability in yeast, Science, 333, 1026, 10.1126/science.1206412 Nawata, 2011, Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes, PLoS One, 6e25319 Nicholson, 2015, Chromosome mis-segregation and cytokinesis failure in trisomic human cells, Elife, 4, 1, 10.7554/eLife.05068 Upender, 2004, Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells, Cancer Res., 64, 6941, 10.1158/0008-5472.CAN-04-0474 Stingele, 2012, Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells, Mol. Syst. Biol., 8, 608, 10.1038/msb.2012.40 Settembre, 2011, TFEB links autophagy to lysosomal biogenesis, Science, 332, 1429, 10.1126/science.1204592 Santaguida, 2015, Aneuploidy-induced cellular stresses limit autophagic degradation, Genes Dev., 1 Soule, 1990, Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10, Cancer Res., 50, 6075 Marella, 2009, Cytogenetic and cDNA microarray expression analysis of MCF10 human breast cancer progression cell lines, Cancer Res., 69, 5946, 10.1158/0008-5472.CAN-09-0420 Ariyoshi, 2007, Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells, J. Radiat. Res., 48, 219, 10.1269/jrr.07017 Ariyoshi, 2009, Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene, J. Radiat. Res., 50, 253, 10.1269/jrr.08111 Li, 2010, The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis, Proc. Natl. Acad. Sci. U. S. A., 107, 14188, 10.1073/pnas.1005960107 Dephoure, 2014, Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast, Elife, e03023, 10.7554/eLife.03023 Kumari, 2014, Induction of p21CIP1 protein and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species, J. Biol. Chem., 289, 16072, 10.1074/jbc.M114.555060 Rohen, 1995, Trisomy 8 and 18 as frequent clonal and single-cell aberrations in 185 primary breast carcinomas, Cancer Genet. Cytogenet., 80, 33, 10.1016/0165-4608(94)00164-7 Bullerdiek, 1993, Trisomy 8 as a recurrent clonal abnormality in breast cancer?, Cancer Genet. Cytogenet., 65, 64, 10.1016/0165-4608(93)90060-Y Roka, 1998, Aneuploidy of chromosome 8 as detected by interphase fluorescence in situ hybridization is a recurrent finding in primary and metastatic breast cancer, Breast Cancer Res. Treat., 48, 125, 10.1023/A:1005937305102 Zientek-Targosz, 2008, Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: a model for identifying candidate breast-tumor suppressors, Mol. Cancer., 7, 51, 10.1186/1476-4598-7-51 Busciglio, 1995, Apoptosis and increased generation of reactive oxygen species in Down’s syndrome neurons in vitro, Nature, 378, 776, 10.1038/378776a0 Schuchmann, 2000, Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down’s syndrome, Free Radic. Biol. Med., 28, 235, 10.1016/S0891-5849(99)00226-9 Williams, 2008, Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells, Science, 322, 703, 10.1126/science.1160058 Mathew, 2007, Autophagy suppresses tumor progression by limiting chromosomal instability, Genes Dev., 21, 1367, 10.1101/gad.1545107 Lee, 2012, Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling, Biochem. J, 441, 523, 10.1042/BJ20111451