Induction of ferroptosis using functionalized iron-based nanoparticles for anti-cancer therapy

Riehemann, 2009, Nanomedicine-challenge and perspectives, Angew. Chem., Int. Ed., 48, 872, 10.1002/anie.200802585 Shapira, 2011, Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance, Drug Resist. Updates, 14, 150, 10.1016/j.drup.2011.01.003 Wicki, 2015, Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications, J. Contr. Release, 200, 138, 10.1016/j.jconrel.2014.12.030 Shi, 2017, Cancer nanomedicine: progress, challenges and opportunities, Nat. Rev. Cancer, 17, 20, 10.1038/nrc.2016.108 Owens, 2006, Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles, Int. J. Pharm., 307, 93, 10.1016/j.ijpharm.2005.10.010 Champion, 2007, Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers, J. Contr. Release, 121, 3, 10.1016/j.jconrel.2007.03.022 Sumer, 2008, Theranostic nanomedicine for cancer, Nanomedicine-Uk, 3, 137, 10.2217/17435889.3.2.137 Wilczewska, 2012, Nanoparticles as drug delivery systems, Pharmacol. Rep., 64, 1020, 10.1016/S1734-1140(12)70901-5 Steichen, 2013, A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics, Eur. J. Pharmaceut. Sci., 48, 416, 10.1016/j.ejps.2012.12.006 Yu, 2012, Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy, Theranostics, 2, 3, 10.7150/thno.3463 Fulda, 2006, Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy, Oncogene, 25, 4798, 10.1038/sj.onc.1209608 Bold, 1997, Apoptosis, cancer and cancer therapy, Surg Oncol, 6, 133, 10.1016/S0960-7404(97)00015-7 Sidhu, 1993, Tumor-necrosis-factor Activities and cancer-therapy - a perspective, Pharmacol. Therapeut., 57, 79, 10.1016/0163-7258(93)90037-E Jain, 2013, Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development, J. Cell Mol. Med., 17, 12, 10.1111/jcmm.12001 Su, 2016, Cancer therapy in the necroptosis era, Cell Death Differ., 23, 748, 10.1038/cdd.2016.8 Dixon, 2012, Ferroptosis: an iron-dependent form of nonapoptotic cell death, Cell, 149, 1060, 10.1016/j.cell.2012.03.042 Bogdan, 2016, Regulators of iron homeostasis: new players in metabolism, cell death, and disease, Trends Biochem. Sci., 41, 274, 10.1016/j.tibs.2015.11.012 Yu, 2017, Ferroptosis, a new form of cell death, and its relationships with tumourous diseases, J. Cell Mol. Med., 21, 648, 10.1111/jcmm.13008 Xie, 2016, Ferroptosis: process and function, Cell Death Differ., 23, 369, 10.1038/cdd.2015.158 Kim, 2016, Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth, Nat. Nanotechnol., 11, 977, 10.1038/nnano.2016.164 Zheng, 2017, Switching apoptosis to ferroptosis: metal-organic network for high-efficiency anticancer therapy, Nano Lett., 17, 284, 10.1021/acs.nanolett.6b04060 Wang, 2018, Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics, ACS Nano, 12, 12380, 10.1021/acsnano.8b06399 Zhang, 2019, Engineering magnetosomes for ferroptosis/immunomodulation synergism in cancer, ACS Nano, 13, 5662, 10.1021/acsnano.9b00892 Meng, 2019, Triggered all-active metal organic framework: ferroptosis machinery contributes to the apoptotic photodynamic antitumor therapy, Nano Lett., 19, 7866, 10.1021/acs.nanolett.9b02904 Liu, 2018, Ferrous-supply-regeneration nanoengineering for cancer-cell-specific ferroptosis in combination with imaging-guided photodynamic therapy, ACS Nano, 12, 12181, 10.1021/acsnano.8b05860 Zhang, 2022, A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy, Nanoscale Horiz, 7, 198, 10.1039/D1NH00506E Song, 2021, Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer, Adv Mater, 33, 10.1002/adma.202101155 Kim, 2019, Hyaluronic acid-coated nanomedicine for targeted cancer therapy, Pharmaceutics, 11, 10.3390/pharmaceutics11070301 Lee, 2020, Hyaluronic acid-based theranostic nanomedicines for targeted cancer therapy, Cancers, 12, 10.3390/cancers12040940 Flory, 1941, Molecular size distribution in three dimensional polymers. II. Trifunctional branching units, J. Am. Chem. Soc., 63, 3091, 10.1021/ja01856a062 Vorvolakos, 2011, Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel, Med Devices (Auckl), 4, 1 Peach, 1993, Identification of hyaluronic-acid binding-sites in the extracellular domain of Cd44, J. Cell Biol., 122, 257, 10.1083/jcb.122.1.257 Lesley, 1992, Requirements for hyaluronic-acid binding by Cd44 - a role for the cytoplasmic domain and activation by antibody, J. Exp. Med., 175, 257, 10.1084/jem.175.1.257 Zoller, 2011, CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?, Nat. Rev. Cancer, 11, 254, 10.1038/nrc3023 Winter, 1977, Hyaluronic acid: the role of divalent cations in conformation and packing, J. Mol. Biol., 117, 761, 10.1016/0022-2836(77)90068-7 Jiang, 2015, Ferroptosis as a p53-mediated activity during tumour suppression, Nature, 520, 57, 10.1038/nature14344 Gao, 2016, Ferroptosis is an autophagic cell death process, Cell Res., 26, 1021, 10.1038/cr.2016.95 Shen, 2018, Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors, ACS Nano, 12, 11355, 10.1021/acsnano.8b06201 He, 2020, Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator, Biomaterials, 241 Shen, 2018, Emerging strategies of cancer therapy based on ferroptosis, Adv. Mater., 30 Boutry, 2009, How to quantify iron in an aqueous or biological matrix: a technical note, Contrast Media Mol. Imaging, 4, 299, 10.1002/cmmi.291 Zhu, 2012, Enhanced cellular uptake of aminosilane-coated superparamagnetic iron oxide nanoparticles in mammalian cell lines, Int. J. Nanomed., 7, 953 Torti, 2013, Iron and cancer: more ore to be mined, Nat. Rev. Cancer, 13, 342, 10.1038/nrc3495 Yang, 2014, Regulation of ferroptotic cancer cell death by GPX4, Cell, 156, 317, 10.1016/j.cell.2013.12.010 Angeli, 2014, Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice, Nat. Cell Biol., 16 Zong, 2003, Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis, J. Cell Biol., 162, 59, 10.1083/jcb.200302084 Moujalled, 2013, TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1, Cell Death Dis., 4, 10.1038/cddis.2012.201 Sui, 2018, RSL3 drives ferroptosis through GPX4 inactivation and ROS production in colorectal cancer, Front. Pharmacol., 9, 10.3389/fphar.2018.01371