Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys

Science Bulletin - Tập 66 - Trang 937-946 - 2021
Shi-Hao Wu1,2, Xiao Li1,3, Dong-Dong Qin4, Lin-Heng Zhang2,5, Tian-Lin Cheng1, Zhi-Fang Chen1, Bin-Bin Nie6,7, Xiao-Feng Ren2,5, Jing Wu2, Wen-Chao Wang2, Ying-Zhou Hu2, Yi-Lin Gu2, Long-Bao Lv8, Yong Yin9, Xin-Tian Hu2,10,8, Zi-Long Qiu1,10,11
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China
2Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
3Academy for Engineering & Technology, Fudan University, Shanghai 200433, China
4Yunnan University of Chinese Medicine, Kunming 650500, China
5Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming 650204, China
6Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China
7School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
8National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650107, China
9Department of Rehabilitation Medicine, the Second People’s Hospital of Yunnan Province, Kunming 650021, China
10Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
11National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China

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