Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

Anand, 2003, AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol, Cancer Cell, 3, 51, 10.1016/S1535-6108(02)00235-0 Andreassen, 1994, Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells, J. Cell Biol., 127, 789, 10.1083/jcb.127.3.789 Bharadwaj, 2004, The spindle checkpoint, aneuploidy, and cancer, Oncogene, 23, 2016, 10.1038/sj.onc.1207374 Blangy, 1995, Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo, Cell, 83, 1159, 10.1016/0092-8674(95)90142-6 Cahill, 1998, Mutations of mitotic checkpoint genes in human cancers, Nature, 392, 300, 10.1038/32688 Chen, 2003, Gene expression and mitotic exit induced by microtubule-stabilizing drugs, Cancer Res., 63, 7891 Cory, 2002, The Bcl2 family: Regulators of the cellular life-or-death switch, Nat. Rev. Cancer, 2, 647, 10.1038/nrc883 Crosio, 2002, Mitotic phosphorylation of histone H3: Spatio-temporal regulation by mammalian Aurora kinases, Mol. Cell. Biol., 22, 874, 10.1128/MCB.22.3.874-885.2002 Dagenbach, 2004, A new kinesin tree, J. Cell Sci., 117, 3, 10.1242/jcs.00875 Dai, 2004, Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency, Cancer Res., 64, 440, 10.1158/0008-5472.CAN-03-3119 Davis, 1983, Monoclonal antibodies to mitotic cells, Proc. Natl. Acad. Sci. USA, 80, 2926, 10.1073/pnas.80.10.2926 Enos, 1990, Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans, Cell, 60, 1019, 10.1016/0092-8674(90)90350-N Gray, 1998, Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors, Science, 281, 533, 10.1126/science.281.5376.533 Hanks, 2004, Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B, Nat. Genet., 36, 1159, 10.1038/ng1449 Hasegawa, 2003, Prediction of response to docetaxel by quantitative analysis of class I and III beta-tubulin isotype mRNA expression in human breast cancers, Clin. Cancer Res., 9, 2992 Hsu, 1998, Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations, J. Biol. Chem., 273, 10777, 10.1074/jbc.273.17.10777 Jin, 1998, Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1, Cell, 93, 81, 10.1016/S0092-8674(00)81148-4 Jordan, 2004, Microtubules as a target for anticancer drugs, Nat. Rev. Cancer, 4, 253, 10.1038/nrc1317 Jordan, 1993, Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations, Proc. Natl. Acad. Sci. USA, 90, 9552, 10.1073/pnas.90.20.9552 Kapoor, 2000, Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5, J. Cell Biol., 150, 975, 10.1083/jcb.150.5.975 Kops, 2004, Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint, Proc. Natl. Acad. Sci. USA, 101, 8699, 10.1073/pnas.0401142101 Lanni, 1998, Characterization of the p53-dependent postmitotic checkpoint following spindle disruption, Mol. Cell. Biol., 18, 1055, 10.1128/MCB.18.2.1055 Li, 1996, Identification of a human mitotic checkpoint gene: hsMAD2, Science, 274, 246, 10.1126/science.274.5285.246 Li, 1998, Control of apoptosis and mitotic spindle checkpoint by survivin, Nature, 396, 580, 10.1038/25141 Li, 1999, BUBR1 phosphorylation is regulated during mitotic checkpoint activation, Cell Growth Differ., 10, 769 Margolis, 2003, G1 tetraploidy checkpoint and the suppression of tumorigenesis, J. Cell. Biochem., 88, 673, 10.1002/jcb.10411 Mayer, 1999, Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen, Science, 286, 971, 10.1126/science.286.5441.971 Michel, 2001, MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells, Nature, 409, 355, 10.1038/35053094 Michel, 2004, Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells, Proc. Natl. Acad. Sci. USA, 101, 4459, 10.1073/pnas.0306069101 Minn, 1996, Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage, Genes Dev., 10, 2621, 10.1101/gad.10.20.2621 Monzo, 1999, Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations, J. Clin. Oncol., 17, 1786, 10.1200/JCO.1999.17.6.1786 Musacchio, 2002, The spindle checkpoint: Structural insights into dynamic signalling, Nat. Rev. Mol. Cell Biol., 3, 731, 10.1038/nrm929 Nechushtan, 1999, Conformation of the Bax C-terminus regulates subcellular location and cell death, EMBO J., 18, 2330, 10.1093/emboj/18.9.2330 O’Connor, 2000, Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin, Proc. Natl. Acad. Sci. USA, 97, 13103, 10.1073/pnas.240390697 O’Connor, 2002, A p34(cdc2) survival checkpoint in cancer, Cancer Cell, 2, 43, 10.1016/S1535-6108(02)00084-3 Rowinsky, 1993, Neurotoxicity of taxol, J. Natl. Cancer Inst. Monogr., 15, 107 Sakowicz, 2004, Antitumor activity of a kinesin inhibitor, Cancer Res., 64, 3276, 10.1158/0008-5472.CAN-03-3839 Sawin, 1995, Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle, Proc. Natl. Acad. Sci. USA, 92, 4289, 10.1073/pnas.92.10.4289 Sawin, 1992, Mitotic spindle organization by a plus-end-directed microtubule motor, Nature, 359, 540, 10.1038/359540a0 Sherr, 1996, Cancer cell cycles, Science, 274, 1672, 10.1126/science.274.5293.1672 Shin, 2003, Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability, Cancer Cell, 4, 483, 10.1016/S1535-6108(03)00302-7 Srivastava, 1999, Molecular dissection of nucleolin’s role in growth and cell proliferation: New insights, FASEB J., 13, 1911, 10.1096/fasebj.13.14.1911 Sudo, 2004, Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint, Cancer Res., 64, 2502, 10.1158/0008-5472.CAN-03-2013 Tao, 2001, Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1, Genes Dev., 15, 1796, 10.1101/gad.894301 Taylor, 1997, Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage, Cell, 89, 727, 10.1016/S0092-8674(00)80255-X Torres, 1998, Mechanisms of Taxol-induced cell death are concentration dependent, Cancer Res., 58, 3620 Tuxen, 1994, Neurotoxicity secondary to antineoplastic drugs, Cancer Treat. Rev., 20, 191, 10.1016/0305-7372(94)90027-2 Vale, 1997, The design plan of kinesin motors, Annu. Rev. Cell Dev. Biol., 13, 745, 10.1146/annurev.cellbio.13.1.745 Wang, 2002, Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells, Cancer Res., 62, 1662 Wei, 2001, Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death, Science, 292, 727, 10.1126/science.1059108 Wolter, 1997, Movement of Bax from the cytosol to mitochondria during apoptosis, J. Cell Biol., 139, 1281, 10.1083/jcb.139.5.1281 Wood, 2001, Past and future of the mitotic spindle as an oncology target, Curr. Opin. Pharmacol., 1, 370, 10.1016/S1471-4892(01)00064-9 Woods, 1995, Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway, Mol. Med., 1, 506, 10.1007/BF03401588 Yang, 1990, Evidence that the head of kinesin is sufficient for force generation and motility in vitro, Science, 249, 42, 10.1126/science.2142332 Zhou, 2000, The DNA damage response: Putting checkpoints in perspective, Nature, 408, 433, 10.1038/35044005