Inducible nonviral gene expression in the treatment of osteochondral defects

Curl, 1997, Cartilage injuries: a review of 31.516 knee arthroscopies, Arthroscopy, 13, 456, 10.1016/S0749-8063(97)90124-9 Martinek, 2001, Treatment of osteochondral injuries. Genetic engineering, Clin Sports Med, 20, 403, 10.1016/S0278-5919(05)70313-6 Johnson, 2001, Arthroscopic abrasion arthroplasty: a review, Clin Orthop, 391, S306, 10.1097/00003086-200110001-00028 Pridie, 1959, A method of resurfacing osteoarthritic knee joints, J Bone Joint Surg (Br), 41, 618 Steadman, 2001, Microfracture: surgical technique and rehabilitation to treat chondral defects, Clin Orthop, 391, S362, 10.1097/00003086-200110001-00033 Bobic, 1999, Autologous osteo-chondral grafts in the management of articular cartilage lesions, Orthopade, 28, 19 Imhoff, 1999, Autologous osteochondral transplantation on various joints, Orthopade, 28, 33 Brittberg, 1994, Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation, N Engl J Med, 331, 889, 10.1056/NEJM199410063311401 Buckwalter, 1998, Articular cartilage: tissue design and chondrocyte–matrix interactions, Instr Course Lect, 47, 477 Mankin, 1982, The response of articular cartilage to mechanical injury, J Bone Joint Surg (Am), 64, 460, 10.2106/00004623-198264030-00022 Huard, 2003, Gene therapy and tissue engineering for sports medicine, J Gene Med, 5, 93, 10.1002/jgm.344 Messner, 1996, Cartilage repair. A critical review, Acta Orthop Scand, 67, 523, 10.3109/17453679608996682 Brun, 1999, Chondrocyte aggregation and reorganization into three-dimensional scaffolds, J Biomed Mater Res, 46, 337, 10.1002/(SICI)1097-4636(19990905)46:3<337::AID-JBM5>3.0.CO;2-Q Hendrickson, 1994, Chondrocyte–fibrin matrix transplants for resurfacing extensive articular cartilage defects, J Orthop Res, 12, 485, 10.1002/jor.1100120405 Martinek, 1999, Gene therapy and tissue engineering in sports medicine, Phys Sports Med, 28, 34, 10.3810/psm.2000.02.691 Osborn, 1989, Growth factor stimulation of adult articular cartilage, J Orthop Res, 7, 35, 10.1002/jor.1100070106 Rosier, 1998, Autocrine regulation of articular cartilage, Instr Course Lect, 47, 469 Sah, 1994, Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants, Arch Biochem Biophys, 308, 137, 10.1006/abbi.1994.1020 Sato, 1984, Bone morphogenetic protein-induced cartilage development in tissue culture, Clin Orthop, 7, 180 Wozney, 1988, Novel regulators of bone formation: molecular clones and activities, Science, 242, 1528, 10.1126/science.3201241 Evans, 1995, Possible orthopaedic applications of gene therapy, J Bone Joint Surg (Am), 77, 1103, 10.2106/00004623-199507000-00021 Ikeda, 2000, Ex vivo gene delivery using an adenovirus vector in treatment for cartilage defects, J Rheumatol, 27, 990 Evans, 2000, Gene therapy in orthopaedics, Orthop Nurs, 19, 16, 10.1097/00006416-200019010-00006 Martinek, 2002, Enhancement of the tendon–bone integration of ACL tendon grafts with BMP-2 gene transfer: a histological and biomechanical study, J Bone Joint Surg (Am), 84, 1123, 10.2106/00004623-200207000-00004 Mulligan, 1993, The basic science of gene therapy, Science, 260, 926, 10.1126/science.8493530 Arai, 1997, Adenovirus vector-mediated gene transduction to chondrocytes in vitro evaluation of therapeutic efficacy of transforming growth factor-beta 1 and heat shock protein 70 gene transduction, J Rheumatol, 24, 1787 Dinser, 2001, Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes, Histochem Cell Biol, 116, 69, 10.1007/s004180100305 Goomer, 2001, High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects, Osteoarthritis Cartilage, 9, 248, 10.1053/joca.2000.0382 Madry, 2003, Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system, J Gene Med, 5, 502, 10.1002/jgm.368 Alden, 1999, In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector, Hum Gene Ther, 10, 2245, 10.1089/10430349950017220 Bobacz, 2002, Cartilage-derived morphogenetic protein-1 and 2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis, Osteoarthritis Cartilage, 10, 394, 10.1053/joca.2002.0522 Gooch, 2002, Bone morphogenetic proteins-2, 12, and 13 modulate in vitro development of engineered cartilage, Tissue Eng, 8, 591, 10.1089/107632702760240517 Morales, 1988, Transforming growth factor β regulates the metabolism of proteoglycans in bovine cartilage organ cultures, J Biol Chem, 263, 12828, 10.1016/S0021-9258(18)37634-8 Crystal, 1995, Transfer of genes to humans: early lessons and obstacles to success, Science, 270, 404, 10.1126/science.270.5235.404 Mills, 2001, Changing colors in mice: an inducible system that delivers, Genes Dev, 15, 1461, 10.1101/gad.909301 Gossen, 1992, Tight control of gene expression in mammalian cells by tetracycline-responsive promoters, Proc Natl Acad Sci USA, 89, 5547, 10.1073/pnas.89.12.5547 Gossen, 1995, Transcriptional activation by tetracyclines in mammalian cells, Science, 268, 1766, 10.1126/science.7792603 Lamartina, 2003, Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline mice and non-human primates, Mol Ther, 7, 271, 10.1016/S1525-0016(02)00051-5 Howe, 1995, The responsiveness of a tetracycline-sensitive expression system differs in different cell lines, J Biol Chem, 270, 14168, 10.1074/jbc.270.23.14168 Furth, 1994, Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter, Proc Natl Acad Sci USA, 91, 9302, 10.1073/pnas.91.20.9302 Shockett, 1995, A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice, Proc Natl Acad Sci USA, 92, 6522, 10.1073/pnas.92.14.6522 Chang, 2000, Tetracycline-inducible system for photoreceptor-specific gene expression, Invest Ophtalmol Vis Sci, 41, 4282 Fishman, 1994, Tetracycline-regulated cardiac gene expression in vivo, J Clin Invest, 93, 1864, 10.1172/JCI117174 Haberman, 1998, Inducible long-term gene expression in brain with adeno-associated virus gene transfer, Gene Ther, 5, 1604, 10.1038/sj.gt.3300782 Mansuy, 1998, Inducible and reversible gene expression with the rtTA System for the study of memory, Neuron, 21, 257, 10.1016/S0896-6273(00)80533-4 Dhawan, 1995, Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle, Somat Cell Mol Genet, 21, 233, 10.1007/BF02255778 Lamartina, 2002, Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators, Hum Gene Ther, 13, 199, 10.1089/10430340252769734 Urlinger, 2000, Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity, Proc Natl Acad Sci USA, 97, 7963, 10.1073/pnas.130192197 Koponen, 2003, Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2s-M2 shows a tight control of gene expression in vitro and in vivo, Gene Ther, 10, 459, 10.1038/sj.gt.3301889 DuBridge, 1987, Analysis of mutation in human cells by using an Epstein–Barr virus shuttle system, Mol Cell Biol, 7, 379, 10.1128/MCB.7.1.379 Hantzopoulos, 1989, Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector, Proc Natl Sci USA, 86, 3519, 10.1073/pnas.86.10.3519 Nolan, 1988, Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-d-galactosidase activity after transduction of Escherichia coli LacZ, Proc Natl Acad Sci USA, 85, 2603, 10.1073/pnas.85.8.2603 Krüger, 1994, Scattered micrometastases visualized at the single-cell level: detection and re-isolation of lacZ-labeled metastasized lymphoma cells, Int J Cancer, 58, 275, 10.1002/ijc.2910580222 Goodman, 2001, The pharmacological basis of therapeutics Baragi, 1997, Transplantation of adenovirally transduced allogeneic chondrocytes into articular cartilage defects in vivo, Osteoarthritis Cartilage, 5, 275, 10.1016/S1063-4584(97)80023-4 Toolan, 1996, Effects of growth factor enhanced culture on a chondrocyte collagen implant for cartilage repair, J Biomed Mater Res, 31, 273, 10.1002/(SICI)1097-4636(199606)31:2<273::AID-JBM15>3.0.CO;2-M Hoerr, 2000, In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies, Eur J Immunol, 30, 1, 10.1002/1521-4141(200001)30:1<1::AID-IMMU1>3.0.CO;2-# Menoret, 2002, LacZ transgenic rats tolerant for beta-galactosidase: recipients for gene transfer studies using lacZ as a reporter gene, Hum Gene Ther, 13, 1383, 10.1089/104303402760128603