Individual elective lymph node irradiation for the reduction of complications in head and neck cancer patients (iNode): A phase-I feasibility trial protocol

Baudelet, 2019, Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy, Head Neck, 41, 3594, 10.1002/hed.25880 Nutting, 2011, Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial, Lancet Oncol, 12, 127, 10.1016/S1470-2045(10)70290-4 Boomsma, 2011, Radiation-induced hypothyroidism in head and neck cancer patients: A systematic review, Radiother Oncol, 99, 1, 10.1016/j.radonc.2011.03.002 Wilbers, 2014, Progression of carotid intima media thickness after radiotherapy: A long-term prospective cohort study, Radiother Oncol, 113, 359, 10.1016/j.radonc.2014.10.012 Carpenter, 2018, The risk of carotid stenosis in head and neck cancer patients after radiation therapy, Oral Oncol, 80, 9, 10.1016/j.oraloncology.2018.02.021 Ramaekers, 2011, The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy, Oral Oncol, 47, 768, 10.1016/j.oraloncology.2011.05.012 Langendijk, 2008, Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy, J Clin Oncol, 26, 3770, 10.1200/JCO.2007.14.6647 Suwinski, 1998, Dose-response relationship for elective neck irradiation of head and neck cancer–facts and controversies, Neoplasma, 45 Kaanders, 2020, Advances in cancer imaging require renewed radiotherapy dose and target volume concepts, Radiother Oncol, 148, 140, 10.1016/j.radonc.2020.04.016 Van Den Bosch, 2016, Patterns of recurrence in electively irradiated lymph node regions after definitive accelerated intensity modulated radiation therapy for head and neck squamous cell Carcinoma, Int J Radiat Oncol Biol Phys, 94, 766, 10.1016/j.ijrobp.2015.12.002 Leeman, 2017, Patterns of treatment failure and postrecurrence outcomes among patients with locally advanced head and neck squamous cell carcinoma after chemoradiotherapy using modern radiation techniques, JAMA Oncol, 3, 1487, 10.1001/jamaoncol.2017.0973 Deschuymer, 2020, Randomized clinical trial on reduction of radiotherapy dose to the elective neck in head and neck squamous cell carcinoma; update of the long-term tumor outcome, Radiother Oncol, 1 Maguire, 2018, Single-Arm Phase 2 Trial of Elective Nodal Dose Reduction for Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck, Int J Radiat Oncol Biol Phys, 100, 1210, 10.1016/j.ijrobp.2017.12.277 Sher, 2021, Prospective Phase 2 Study of Radiation Therapy Dose and Volume De-escalation for Elective Neck Treatment of Oropharyngeal and Laryngeal Cancer, Int J Radiat Oncol Biol Phys, 109, 932, 10.1016/j.ijrobp.2020.09.063 Daisne, 2014, SPECT/CT lymphoscintigraphy of sentinel node(s) for superselective prophylactic irradiation of the neck in cN0 head and neck cancer patients: A prospective phase I feasibility study, Radiat Oncol, 9, 1, 10.1186/1748-717X-9-121 van den Bosch, 2017, Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): Study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma, BMC Cancer, 17, 1, 10.1186/s12885-017-3195-7 De Veij Mestdagh, 2019, Mapping of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial, BMC Cancer, 19, 1, 10.1186/s12885-019-6331-8 Grégoire V, Ang K, Budach W, Grau C, Hamoir M, Langendijk JA, et al. Delineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol 2014;110:172–81. doi:10.1016/j.radonc.2013.10.010. de Ridder, 2022, Target Definition in MR-Guided Adaptive Radiotherapy for Head and Neck Cancer, Cancers (Basel), 14 Reinders, 2022, MRI visibility and displacement of elective lymph nodes during radiotherapy in head and neck cancer patients, Front Radiol, 10.3389/fradi.2022.1033521 Reinders, 2021, Magnetic resonance guided elective neck irradiation targeting individual lymph nodes: A new concept, Phys Imaging Radiat Oncol, 20, 76, 10.1016/j.phro.2021.10.006 de Veij Mestdagh, 2020, SPECT/CT-guided elective nodal irradiation for head and neck cancer is oncologically safe and less toxic: A potentially practice-changing approach, Radiother Oncol, 147, 56, 10.1016/j.radonc.2020.03.012 Glover, 1991, Multipoint dixon technique for water and fat proton and susceptibility imaging, J Magn Reson Imaging, 1, 521, 10.1002/jmri.1880010504 Brouwer, 2015, CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines, Radiother Oncol, 117, 83, 10.1016/j.radonc.2015.07.041 Overgaard, 2003, Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial, Lancet, 362, 933, 10.1016/S0140-6736(03)14361-9 Philippens, 2020, Head-and-neck tumor delineation for MRI guided adaptive (chemo)radiotherapy, ESTRO, POSTER-167 van den Bosch, 2018, Implications of improved diagnostic imaging of small nodal metastases in head and neck cancer: Radiotherapy target volume transformation and dose de-escalation, Radiother Oncol, 128, 472, 10.1016/j.radonc.2018.04.020 Bongers, 2017, Hearing loss associated with repeated MRI acquisition procedure-related acoustic noise exposure: An occupational cohort study, Occup Environ Med, 74, 776, 10.1136/oemed-2016-103750