Individual Factors Including Age, BMI, and Heritable Factors Underlie Temperature Variation in Sickness and in Health: An Observational, Multi-cohort Study

citation_title=Age-dependent changes in temperature regulation - a mini review; citation_author=Blatteis CM; citation_journal_title=Gerontology; citation_year=2012; citation_volume=58; citation_issue=4; citation_pages=289-295; citation_title=Normal body temperature: a systematic review; citation_author=Geneva II; citation_author=Cuzzo B; citation_author=Fazili T; citation_author=Javaid W; citation_journal_title=Open Forum Infect Dis; citation_year=2019; citation_volume=6; citation_issue=4; citation_pages=ofz032 citation_title=Temperature.; citation_author=VE DB.; citation_publisher=Butterworths, Boston; citation_title=Clinical Methods: The History, Physical, and Laboratory Examinations; citation_year=1990; citation_title=Single nucleotide polymorphisms associated with thermoregulation in lactating dairy cows exposed to heat stress; citation_author=Dikmen S; citation_author=Wang XZ; citation_author=Ortega MS; citation_author=Cole JB; citation_author=Null DJ; citation_author=Hansen PJ; citation_journal_title=J Anim Breed Genet; citation_year=2015; citation_volume=132; citation_issue=6; citation_pages=409-419; citation_title=Heritability of body surface temperature in hens estimated by infrared thermography at normal or hot temperatures and genetic correlations with egg and feather quality; citation_author=Loyau T; citation_author=Zerjal T; citation_author=Rodenburg TB; citation_journal_title=Animal; citation_year=2016; citation_volume=10; citation_issue=10; citation_pages=1594-1601; citation_title=Genetic selection for thermotolerance in ruminants; citation_author=Osei-Amponsah R; citation_author=Chauhan SS; citation_author=Leury BJ; citation_journal_title=Animals; citation_year=2019; citation_volume=9; citation_issue=11; citation_pages=948 citation_title=Circadian system heritability as assessed by wrist temperature: a twin study; citation_author=Lopez-Minguez J; citation_author=Ordoñana JR; citation_author=Sánchez-Romera JF; citation_author=Madrid JA; citation_author=Garaulet M; citation_journal_title=Chronobiol Int; citation_year=2015; citation_volume=32; citation_issue=1; citation_pages=71-80; citation_title=Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the Infectious Diseases Society of America; citation_author=High KP; citation_author=Bradley SF; citation_author=Gravenstein S; citation_journal_title=Clin Infect Dis; citation_year=2009; citation_volume=48; citation_issue=2; citation_pages=149-171; citation_title=Fever in the elderly; citation_author=Norman DC; citation_journal_title=Clin Infect Dis; citation_year=2000; citation_volume=31; citation_issue=1; citation_pages=148-151; citation_title=Role of body temperature in diagnosing bacterial infection in nursing home residents; citation_author=Sloane PD; citation_author=Kistler C; citation_author=Mitchell CM; citation_journal_title=J Am Geriatr Soc; citation_year=2014; citation_volume=62; citation_issue=1; citation_pages=135-140; citation_title=Fever response in elderly nursing home residents: are the older truly colder?; citation_author=Castle SC; citation_author=Norman DC; citation_author=Yeh M; citation_author=Miller D; citation_author=Yoshikawa TT; citation_journal_title=J Am Geriatr Soc; citation_year=1991; citation_volume=39; citation_issue=9; citation_pages=853-857; citation_title=Pyrexia in infection in the elderly; citation_author=McAlpine CH; citation_author=Martin BJ; citation_author=Lennox IM; citation_author=Roberts MA; citation_journal_title=Age Ageing; citation_year=1986; citation_volume=15; citation_issue=4; citation_pages=230-234; citation_title=Atypical clinical presentation of geriatric syndrome in elderly patients with pneumonia or coronary artery disease; citation_author=Jung YJ; citation_author=Yoon JL; citation_author=Kim HS; citation_author=Lee AY; citation_author=Kim MY; citation_author=Cho JJ; citation_journal_title=Ann Geriatr Med Res; citation_year=2017; citation_volume=21; citation_issue=4; citation_pages=158-163; citation_title=A secondary analysis of atypical presentations of older patients with infection in the emergency department of a tertiary care hospital in Thailand; citation_author=Limpawattana P; citation_author=Mitsungnern T; citation_author=Phungoen P; citation_author=Tansangworn N; citation_author=Laosuangkoon W; citation_journal_title=Asian Biomed; citation_year=2016; citation_volume=62; citation_pages=97-102; citation_title=Elderly patients with an atypical presentation of illness in the emergency department; citation_author=Hofman MR; citation_author=van den Hanenberg F; citation_author=Sierevelt IN; citation_author=Tulner CR; citation_journal_title=Neth J Med; citation_year=2017; citation_volume=75; citation_issue=6; citation_pages=241-246; citation_title=Innate immunesenescence: underlying mechanisms and clinical relevance; citation_author=Hazeldine J; citation_author=Lord JM; citation_journal_title=Biogerontology; citation_year=2015; citation_volume=16; citation_issue=2; citation_pages=187-201; citation_title=Aging and the immune system: the impact of immunosenescence on viral infection, immunity and vaccine immunogenicity; citation_author=Oh SJ; citation_author=Lee JK; citation_author=Shin OS; citation_journal_title=Immune Netw; citation_year=2019; citation_volume=19; citation_issue=6; citation_pages=e37 citation_title=Frailty is associated with neutrophil dysfunction which is correctable with phosphoinositol-3-kinase inhibitors; citation_author=Wilson D; citation_author=Drew W; citation_author=Jasper A; citation_journal_title=J Gerontol A Biol Sci Med Sci; citation_year=2020; citation_volume=75; citation_issue=12; citation_pages=2320-2325; citation_title=Clinical characteristics of Coronavirus Disease 2019 in China; citation_author=China Medical Treatment Expert Group for Covid-19.; citation_author=Guan WJ; citation_author=Ni ZY; citation_author=Hu Y; citation_journal_title=N Engl J Med; citation_year=2020; citation_volume=382; citation_issue=18; citation_pages=1708-1720; citation_title=Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China; citation_author=Wang D; citation_author=Hu B; citation_author=Hu C; citation_journal_title=JAMA; citation_year=2020; citation_volume=323; citation_issue=11; citation_pages=1061-1069; citation_title=Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China; citation_author=Huang C; citation_author=Wang Y; citation_author=Li X; citation_journal_title=Lancet; citation_year=2020; citation_volume=395; citation_issue=10223; citation_pages=497-506; citation_title=First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020; citation_author=Spiteri G; citation_author=Fielding J; citation_author=Diercke M; citation_journal_title=Eurosurveillance; citation_year=2020; citation_volume=25; citation_issue=9; citation_pages=2000178 citation_title=Coronavirus disease 2019: new things to know!; citation_author=Zayet S; citation_author=Kadiane-Oussou NJ; citation_author=Royer PY; citation_author=Toko L; citation_author=Gendrin V; citation_author=Klopfenstein T; citation_journal_title=J Med Virol; citation_year=2020; citation_volume=92; citation_issue=10; citation_pages=1767-1768; COVID-19: Investigation and Initial Clinical Management of Possible Cases - GOV.UK. https://www.gov.uk/government/publications/wuhan-novel-coronavirus-initial-investigation-of-possible-cases/investigation-and-initial-clinical-management-of-possible-cases-of-wuhan-novel-coronavirus-wn-cov-infection. Updated 14 December, 2020. Accessed 8 July, 2021. Holroyd-Leduc J,Gandell D,Miller A MPD. COVID-19 in Older Adults Resource. 2020. https://www.rgptoronto.ca/wp-content/uploads/2020/04/COVID-19-Presentations-in-Frail-Older-Adults-U-of-C-and-U-fo-T.pdf. citation_title=Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults; citation_author=Zazzara MB; citation_author=Penfold RS; citation_author=Roberts AL; citation_journal_title=Age Ageing; citation_year=2021; citation_volume=50; citation_issue=1; citation_pages=40-48; citation_title=Detecting SARS-CoV-2 at point of care: preliminary data comparing loop-mediated isothermal amplification (LAMP) to polymerase chain reaction (PCR); citation_author=Österdahl MF; citation_author=Lee KA; citation_author=Lochlainn MN; citation_journal_title=BMC Infect Dis; citation_year=2020; citation_volume=20; citation_issue=1; citation_pages=783 citation_title=TwinsUK: The UK Adult Twin Registry Update; citation_author=Verdi S; citation_author=Abbasian G; citation_author=Bowyer RCE; citation_journal_title=Twin Res Hum Genet; citation_year=2019; citation_volume=22; citation_issue=6; citation_pages=523-529; citation_title=Innovations in geriatric medicine: inception and dissemination of a national trainee-led research collaborative; citation_author=Geriatric Medicine Research Collaborative.; citation_journal_title=Future Healthc J; citation_year=2019; citation_volume=6; citation_issue=Suppl 1; citation_pages=118 citation_title=Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study; citation_author=Geriatric Medicine Research Collaborative; Covid Collaborative, Welch C.; citation_journal_title=Age Ageing; citation_year=2021; citation_volume=50; citation_issue=3; citation_pages=617-630; citation_title=Real-time tracking of self-reported symptoms to predict potential COVID-19; citation_author=Menni C; citation_author=Valdes AM; citation_author=Freidin MB; citation_journal_title=Nat Med; citation_year=2020; citation_volume=26; citation_issue=7; citation_pages=1037-1040; citation_title=OpenMx 2.0: extended structural equation and statistical modeling; citation_author=Neale MC; citation_author=Hunter MD; citation_author=Pritikin JN; citation_journal_title=Psychometrika; citation_year=2016; citation_volume=81; citation_issue=2; citation_pages=535-549; citation_author=Falconer DS; citation_author=Mackay TFC.; citation_publisher=Longman Scientific & Technical, ; citation_title=Introduction to Quantitative Genetics; citation_year=1996; citation_title=Welcome to the tidyverse; citation_author=Wickham; citation_journal_title=J Open Source Softw; citation_year=2019; citation_volume=4; citation_issue=43; citation_pages=1686 citation_title=Fitting linear mixed-effects models using lme4; citation_author=Bates D; citation_author=Mächler M; citation_author=Bolker BM; citation_author=Walker SC; citation_journal_title=J Stat Softw; citation_year=2015; citation_volume=67; citation_issue=1; citation_pages=1-48; citation_title=Errors in body temperature assessment related to individual variation, measuring technique and equipment; citation_author=Sund-Levander M; citation_author=Grodzinsky E; citation_author=Loyd D; citation_author=Wahren LK; citation_journal_title=Int J Nurs Pract; citation_year=2004; citation_volume=10; citation_issue=5; citation_pages=216-223; citation_title=Association of body temperature with obesity. The CoLaus study; citation_author=Bastardot F; citation_author=Marques-Vidal P; citation_author=Vollenweider P; citation_journal_title=Int J Obes (Lond); citation_year=2019; citation_volume=43; citation_issue=5; citation_pages=1026-1033; citation_title=Should clinical case definitions of influenza in hospitalized older adults include fever?; citation_author=Falsey AR; citation_author=Baran A; citation_author=Walsh EE; citation_journal_title=Influenza Other Respir Viruses; citation_year=2015; citation_volume=9; citation_issue=Suppl 1; citation_pages=23-29; citation_title=The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study; citation_author=COPE Study Collaborators.; citation_author=Hewitt J; citation_author=Carter B; citation_author=Vilches-Moraga A; citation_journal_title=Lancet Public Health; citation_year=2020; citation_volume=5; citation_issue=8; citation_pages=e444-e451; citation_title=Gender differences in thermoregulation; citation_author=Kaciuba-Uscilko H; citation_author=Grucza R; citation_journal_title=Curr Opin Clin Nutr Metab Care; citation_year=2001; citation_volume=4; citation_issue=6; citation_pages=533-536; Office for National Statistics. Overview of the Population. https://www.ons.gov.uk/peoplepopulationandcommunity/populationandmigration/populationestimates/articles/overviewoftheukpopulation/august2019. https://www.ons.gov.uk/peoplepopulationandcommunity/populationandmigration/populationestimates/articles/overviewoftheukpopulation/august2019. Published 2019. citation_author=ONS.; citation_publisher=Office for National Statistics, ; citation_year=2020; citation_pages=1-12;