Indirect evidence of sympathetic stimulation by regadenoson

Andrikopoulou E, Hage FG. Heart rate response to regadenoson: Making the case for its value in clinical practice. J Nucl Cardiol 2016;23:575-80. Jamali HK, Wagar F, Gerson MC. Cardiac autonomic innervation. J Nucl Cardiol 2017;24:1558-70. Lexiscan® [package insert]. Northbrook, IL: Astellas Pharma US Inc; 2008. Henzlova MJ, Duvall WL, Einstein AJ, Travin MI, Verberne HJ. ASNS imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers. J Nucl Cardiol 2016;23:606-39. Dhalla AK, Wone MY, Wang WQ, Biaggioni I, Belardinelli L. Tachycardia caused by A2a adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats. J Pharmacol Exp Ther 2006;316:695-702. Hage FG, Heo J, Franks B, Belardinelli L, Blackburn B, Wang W, Iskandrian AE. Differences in heart rate responses to adenosine and regadenoson in patients with and without diabetes mellitus. Am Heart J 2009;157:771-6. Hage FG, Dean P, Iqbal F, Heo J, Iskandrian AE. A blunted heart rate response to regadenoson is an independent prognostic indicator in patients undergoing myocardial perfusion imaging. J Nucl Cardiol 2011;18:1086-94. Witbrodt B, Goyal A, Kelkar AA, Dorbala S, Chow BJW, DiCarli MF, Williams BA, Merhige MF, Berman DS, Germano G, Beanlands RS, Min JK, Arasaratnam P, Sadreddini M, van Velthuiisen ML, Shaw LJ. Prognostic significance of blood pressure response during vasodilator stress Rb-82 positron emission tomography myocardial perfusion imaging. J Nucl Cardiol 2017;24:1966-75.