Incremento de las citoquinas proteína quimiotáctica de monocitos-1 (MCP-1) y proteína inflamatoria macrofágica-1β (MIP-1β) en líquido cefalorraquídeo de pacientes con esclerosis lateral amiotrófica

Mills, 2003, The natural history of central motor abnormalities in amyotrophic lateral sclerosis, Brain., 136, 2558, 10.1093/brain/awg260 Toft, 2005, The size distribution of neurons in the motor cortex in amyotrophic lateral sclerosis, J Anat., 207, 399, 10.1111/j.1469-7580.2005.00465.x Ringel, 1993, The natural history of amyotrophic lateral sclerosis, Neurology., 43, 1316, 10.1212/WNL.43.7.1316 Ravits, 2013, Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis, Amyotroph Lateral Scler Frontotemporal Degener., 14, 5, 10.3109/21678421.2013.778548 Zhao, 2013, Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis, J Neuroimmune Pharmacol., 8, 888, 10.1007/s11481-013-9489-x Beers, 2011, Neuroinflammation modulates distinct regional and temporal clinical responses in ELA, Brain Behav Immun., 25, 1025, 10.1016/j.bbi.2010.12.008 Philips, 2011, Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease, Lancet Neurol., 10, 253, 10.1016/S1474-4422(11)70015-1 McCombe, 2011, The role of immune and inflammatory mechanisms in ELA, Curr Mol Med., 11, 246, 10.2174/156652411795243450 Liu, 2015, Elevated levels of IFN-γ in CSF and serum of patients with amyotrophic lateral sclerosis, PLoS One., 10, e0136837 Winkler, 2013, Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis, Acta Neuropathol., 125, 111, 10.1007/s00401-012-1039-8 Rezai-Zadeh, 2009, CNS infiltration of peripheral immune cells: D-day for neurodegenerative disease?, J Neuroimmune Pharmacol., 4, 462, 10.1007/s11481-009-9166-2 Henkel, 2004, Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue, Ann Neurol., 55, 221, 10.1002/ana.10805 Wilms, 2003, Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: Further evidence for microglial activation in neurodegeneration, J Neuroimmunol., 144, 139, 10.1016/j.jneuroim.2003.08.042 Maurer, 2004, Macrophage inflammatory protein-1, Int J Biochem Cell Biol., 36, 1882, 10.1016/j.biocel.2003.10.019 Boven, 2000, Macrophage inflammatory protein-1 alpha (MIP-1alpha), MIP1beta, and RANTES mRNA semi quantification and protein expression in active demyelinating multiple sclerosis (MS) lesions, Clin Exp Immunol., 122, 257, 10.1046/j.1365-2249.2000.01334.x Henkel, 2006, The chemokine MCP-1 and the dendritic and myeloid cells it attacks are increased in the mSOD1 mouse model of ELA, Mol Cell Neurosci., 31, 427, 10.1016/j.mcn.2005.10.016 Brooks, 2000, El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis, Amyotroph Lateral Scler Other Motor Neuron Disord., 1, 293, 10.1080/146608200300079536 Kaufmann, 2005, The ALSFRS-R predicts survival time in an ELA clinic population, Neurology., 64, 38, 10.1212/01.WNL.0000148648.38313.64 Kawamata, 1992, Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue, Am J Pathol., 140, 691 Proudfoot, 2002, Chemokine receptors: Multifaceted therapeutic targets, Nat Rev Immunol., 2, 106, 10.1038/nri722 Tejera-Alhambra, 2015, Plasma biomarkers discriminate clinical forms of multiple sclerosis, PLoS One., 10, e0128e952, 10.1371/journal.pone.0128952 Kuhle, 2009, Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis, Eur J Neurol., 16, 771, 10.1111/j.1468-1331.2009.02560.x Tanaka, 2006, Intrathecal upregulation of granulocyte colony stimulating factor and its neuroprotective actions on motor neuron in amyotrophic lateral sclerosis, J Neuropathol Exp Neurol., 65, 816, 10.1097/01.jnen.0000232025.84238.e1 Hooten, 2015, Protective and toxic neuroinflammation in amyotrophic lateral sclerosis, Neurotherapeutics., 12, 364, 10.1007/s13311-014-0329-3