Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

Report by Technology Catalysts International Corporation, Delivery of poorly soluble drugs, third ed., Falls Church, VA, USA, 2002.

Lipinski, 1997, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development setting, Adv. Drug Deliv. Rev., 23, 3, 10.1016/S0169-409X(96)00423-1

Leuner, 2000, Improving drug solubility for oral delivery using solid dispersions, Eur. J. Pharm., 50, 47, 10.1016/S0939-6411(00)00076-X

Hong, 2006, A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption, J. Control. Release, 110, 332, 10.1016/j.jconrel.2005.10.002

Rabinow, 2004, Nanosuspensions in drug delivery, Nat. Rev. Drug Discov., 3, 785, 10.1038/nrd1494

Vallet-Regi, 2006, Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering, Chem. Eur. J., 12, 5934, 10.1002/chem.200600226

Chang, 2003, Preparation and application of nanocatalysts via surface functionalization of mesoporous materials, Res. Chem. Intermed., 29, 921, 10.1163/156856703322601915

Yiu, 2005, Enzymes supported on ordered mesoporous solids: a special case of an inorganic–organic hybrid, J. Mater. Chem., 15, 3690, 10.1039/b506090g

Beck, 1992, A new family of mesoporous molecular sieves prepared with liquid-crystal templates, J. Am. Chem. Soc., 114, 10834, 10.1021/ja00053a020

Zhao, 1998, Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores, Science, 279, 548, 10.1126/science.279.5350.548

Kosuge, 2004, Morphological control of rod- and fiberlike SBA-15 Type mesoporous silica using water-soluble sodium silicate, Chem. Mater., 16, 899, 10.1021/cm030622u

Kruk, 2000, Characterization of the porous structure of SBA-15, Chem. Mater., 12, 1961, 10.1021/cm000164e

Vallet-Regi, 2006, Revisiting silica based ordered mesoporous materials: medical applications, J. Mater. Chem., 16, 26, 10.1039/B509744D

Vallet-Regi, 2001, A new property of MCM-41: drug delivery system, Chem. Mater., 13, 308, 10.1021/cm0011559

Horcajada, 2004, Influence of pore size of MCM-41 matrices on drug delivery rate, Microporous Mesoporous Mater., 68, 105, 10.1016/j.micromeso.2003.12.012

Andersson, 2004, Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices, Chem. Mater., 16, 4160, 10.1021/cm0401490

Munoz, 2003, MCM-41 organic modification as drug delivery rate regulator, Chem. Mater., 15, 500, 10.1021/cm021217q

Charnay, 2004, Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property, Eur. J. Pharm. Biopharm., 57, 533, 10.1016/j.ejpb.2003.12.007

Azaı¨s, 2006, Solid-state NMR study of ibuprofen confined in MCM-41 material, Chem. Mater., 18, 6382, 10.1021/cm061551c

Heikkila, 2007, Mesoporous silica material TUD-1 as a drug delivery system, Int. J. Pharm., 331, 133, 10.1016/j.ijpharm.2006.09.019

Mellaerts, 2007, Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials, Chem. Commun., 13, 1375, 10.1039/b616746b

Six, 2005, Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion, Eur. J. Pharm. Sci., 24, 179, 10.1016/j.ejps.2004.10.005

Lippens, 1965, Studies on pore systems in catalysts. V. The t method, J. Catal., 4, 319, 10.1016/0021-9517(65)90307-6

Barrett, 1951, The determination of pore volume and area distribution in porous substances, J. Am. Chem. Soc., 73, 373, 10.1021/ja01145a126

Paikoff, 1965, Method for evaluating dissolution characteristics of capsules, J. Pharm. Sci., 54, 1693, 10.1002/jps.2600541136

Yoo, 2002, Interspecies comparison of the oral absorption of itraconazole in laboratory animals, Arch. Pharm. Res., 25, 387, 10.1007/BF02976644

Maeda, 1977, Use of rabbits for GI drug absorption studies, J. Pharm. Sci., 66, 69, 10.1002/jps.2600660117

Aoyagi, 1992, Gastric emptying of tablets and granules in humans, dogs, pigs and stomach-emptying-controlled rabbits, J. Pharm. Sci., 81, 1170, 10.1002/jps.2600811208