Tăng cường gãy xương hình thái đốt sống ở bệnh nhân suy cận giáp sau phẫu thuật mặc dù mật độ khoáng xương bình thường
Tóm tắt
Cơ chế kích hoạt tái tạo xương của hormone cận giáp (PTH) phụ thuộc rất nhiều vào thời gian tiếp xúc của tế bào xương với nồng độ hormone. Mức PTH cao kéo dài kích hoạt quá trình phân giải, trong khi các đợt tăng cường tạm thời kích thích quá trình đồng hóa. Những ảnh hưởng của chứng suy cận giáp (PhPT) lên xương vẫn chưa được biết đến. Mục tiêu của nghiên cứu là để khảo sát tác động của PhPT đến mật độ khoáng xương (BMD), tần suất gãy đốt sống ở mức độ tiềm ẩn và hình thái học xương hàm dưới.
Từ khóa
#Bệnh nhân suy cận giáp #mật độ khoáng xương #gãy đốt sống #hình thái học xương hàm dướiTài liệu tham khảo
Jilka RL: Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone. 2007, 40: 1434-1446. 10.1016/j.bone.2007.03.017.
Jilka RL, O’Brien CA, Bartell SM, Weinstein RS, Manolagas SC: Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms. J Bone Miner Res. 2010, 25: 2427-2437. 10.1002/jbmr.145.
de Paula FJ, Rosen CJ: Back to the future: revisiting parathyroid hormone and calcitonin control of bone remodeling. Horm Metab Res. 2010, 42: 299-306. 10.1055/s-0030-1248255.
Pereira LC, Pereira FA, Sá MF, Foss MC, de Paula FJ: Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemia. Maturitas. 2008, 59: 91-94. 10.1016/j.maturitas.2007.10.002.
Silverberg SJ, Shane E, de la Cruz L, Segre GV, Clemens TL, Bilezikian JP: Abnormalities in parathyroid hormone secretion and 1,25-diydroxyvitamin D3 formation in women with osteoporosis. N Engl J Med. 1989, 320: 277-281. 10.1056/NEJM198902023200503.
Rubin MR, Bilezikian JP: Hypoparathyroidism: clinical features, skeletal microstructure and parathyroid hormone replacement. Arq Bras Endocrinol Metabol. 2010, 54: 220-226. 10.1590/S0004-27302010000200019.
Rubin MR, Manavalan JS, Dempster DW, Shah J, Cremers S, Kousteni S, Zhou H, McMahon DJ, Kode A, Sliney J, Shane E, Silverberg SJ, Bilezikian JP: Parathyroid hormone stimulates circulating osteogenic cells in hypoparathyroidism. J Clin Endocrinol Metab. 2011, 96: 176-186. 10.1210/jc.2009-2682.
Laway BA, Goswami R, Singh N, Gupta N, Seith A: Pattern of bone mineral density in patients with sporadic idiopathic hypoparathyroidism. Clin Endocrinol (Oxf). 2006, 64: 405-409.
World Health Organization: Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 1994, Geneva: Switzerland
Khosla S, Melton LJ: Clinical practice. Osteopenia. N Engl J Med. 2007, 356: 2293-2300. 10.1056/NEJMcp070341.
Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J, Burckhardt P, Cooper C, Christiansen C, Cummings S, Eisman JA, Fujiwara S, Glüer C, Goltzman D, Hans D, Krieg MA, La Croix A, McCloskey E, Mellstrom D, Melton LJ, Pols H, Reeve J, Sanders K, Schott AM, Silman A, Torgerson D, van Staa T, Watts NB, Yoshimura N: The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int. 2007, 18: 1033-1046. 10.1007/s00198-007-0343-y.
Seeman E, Delmas PD: Bone quality–the material and structural basis of bone strength and fragility. N Engl J Med. 2006, 354: 2250-2261. 10.1056/NEJMra053077.
Hippisley-Cox J, Coupland C: Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFracture Scores. BMJ. 2009, 339: b4229-10.1136/bmj.b4229.
Vlasiadis KZ, Damilakis J, Velegrakis GA, Skouteris CA, Fragouli I, Goumenou A, Matalliotakis J, Koumantakis EE: Relationship between BMD, dental panoramic radiographic findings and biochemical markers of bone turnover in diagnosis of osteoporosis. Maturitas. 2008, 59: 226-233. 10.1016/j.maturitas.2008.01.006.
Tanner R, Wall BF, Shrimpton PC, Hart D, Bungay DR: Frequency of medical and dental x-ray examination in the UK. 2000, -NRPB-R320
Devlin H, Allen P, Graham J, Jacobs R, Nicopoulou-Karayianni K, Lindh C, Marjanovic E, Adams J, Pavitt S, van der Stelt P, Horner K: The role of the dental surgeon in detecting osteoporosis: the OSTEODENT study. Br Dent J. 2008, 204: E16-10.1038/sj.bdj.2008.317. discussion 560–561
Watanabe PC, Farman A, Watanabe MG, Issa JP: Radiographic signals detection of systemic disease. Orthopantomographic Radiography. Int J Morphol. 2008, 26: 915-926.
Horner K, Allen P, Graham J, Jacobs R, Boonen S, Pavitt S, Nackaerts O, Marjanovic E, Adams JE, Karayianni K, Lindh C, van der Stelt P, Devlin H: The relationship between the OSTEODENT index and hip fracture risk assessment using FRAX. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010, 110: 243-249. 10.1016/j.tripleo.2010.03.035.
Bras J, van Ooij CP, Abraham-Inpijn K, Kusen GJ, Wilmink JM: Interpretation of the mandibular angular cortex: a diagnostic tool in metabolic bone loss. Part I. Normal state and postmenopausal osteoporosis. Oral Surg. 1982, 53: 541-545. 10.1016/0030-4220(82)90473-X.
Ledgerton D, Horner K, Devlin H, Worthington H: Panoramic mandibular index as a radiomorphometric tool: an assessment of precision. Dentomaxillofac Radiol. 1997, 26: 95-100. 10.1038/sj.dmfr.4600215.
Taguchi A, Suei Y, Ohtsuka M, Otani K, Tanimoto K, Ohtaki M: Usefulness of panoramic radiography in the diagnosis of postmenopausal osteoporosis in women. Width and morphology of inferior cortex of the mandible. Dentomaxillofac Radiol. 1996, 25: 263-267.
Hsieh FY, Bloch DA, Larsen MD: A simple method of sample size calculation for linear and logistic regression. Stat Med. 1998, 17: 1623-1634. 10.1002/(SICI)1097-0258(19980730)17:14<1623::AID-SIM871>3.0.CO;2-S.
Chan FK, Tiu SC, Choi KL, Choi CH, Kong AP, Shek CC: Increased bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab. 2003, 88: 3155-3159. 10.1210/jc.2002-021388.
Rubin MR, Dempster DW, Zhou H, Shane E, Nickolas T, Sliney J, Silverberg SJ, Bilezikian JP: Dynamic and structural properties of the skeleton in hypoparathyroidism. J Bone Miner Res. 2008, 23: 2018-2024. 10.1359/jbmr.080803.
Duan Y, De Luca V, Seeman E: Parathyroid hormone deficiency and excess: similar effects on trabecular bone but differing effects on cortical bone. J Clin Endocrinol Metab. 1999, 84: 718-722. 10.1210/jc.84.2.718.
Currey J: Structural heterogeneity in bone: good or bad?. J Musculoskelet Neuronal Interact. 2005, 5: 317-
Rubin MR, Dempster DW, Kohler T, Stauber M, Zhou H, Shane E, Nickolas T, Stein E, Sliney J, Silverberg SJ, Bilezikian JP, Müller R: Three dimensional cancellous bone structure in hypoparathyroidism. Bone. 2010, 46: 190-195. 10.1016/j.bone.2009.09.020.
Lanyon LE, Baggott DG: Mechanical function as an influence on the structure and form of bone. J Bone Joint Surg Br. 1976, 58-B: 436-443.
Turner CH: Bone strength: current concepts. Ann N Y Acad Sci. 2006, 1068: 429-446. 10.1196/annals.1346.039.
Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O’Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M, American Society for Bone and Mineral Research: Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2010, 25: 2267-2294. 10.1002/jbmr.253.
Ahmad AM, Hopkins MT, Fraser WD, Ooi CG, Durham BH, Vora JP: Parathyroid hormone secretory pattern, circulating activity, and effect on bone turnover in adult growth hormone deficiency. Bone. 2003, 32: 170-179. 10.1016/S8756-3282(02)00952-3.
Ahmad AM, Thomas J, Clewes A, Hopkins MT, Guzder R, Ibrahim H, Durham BH, Vora JP, Fraser WD: Effects of growth hormone replacement on parathyroid hormone sensitivity and bone mineral metabolism. J Clin Endocrinol Metab. 2003, 88: 2860-2868. 10.1210/jc.2002-021787.
White HD, Ahmad AM, Durham BH, Patwala A, Whittingham P, Fraser WD, Vora JP: Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients. J Clin Endocrinol Metab. 2005, 90: 3371-3380. 10.1210/jc.2004-1650.
Ribeiro FB, Pereira Fde A, Muller E, Foss NT, de Paula FJ: Evaluation of bone and mineral metabolism in patients recently diagnosed with leprosy. Am J Med Sci. 2007, 334: 322-326. 10.1097/MAJ.0b013e318142bafb.
Pereira FA, de Castro JA, dos Santos JE, Foss MC, Paula FJ: Impact of marked weight loss induced by bariatric surgery on bone mineral density and remodeling. Braz J Med Biol Res. 2007, 40: 509-517. 10.1590/S0100-879X2006005000074.
de Paula FJ, Rosen CJ: Vitamin D safety and requirements. Arch Biochem Biophys. 2012, 523: 64-72. 10.1016/j.abb.2011.12.002.
Nakchbandi IA, Lang R, Kinder B, Insogna KL: The role of the receptor activator of nuclear factor-kappaB ligand/osteoprotegerin cytokine system in primary hyperparathyroidism. J Clin Endocrinol Metab. 2008, 93: 967-973.
Buxton EC, Yao W, Lane NE: Changes in serum receptor activator of nuclear factor-κB ligand, osteoprotegerin, and interleukin-6 levels in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1–34). J Clin Endocrinol Metab. 2004, 89: 3332-3336. 10.1210/jc.2003-032066.