Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients
Tóm tắt
Myeloid-related protein 8/14 (MRP8/14) is a stable heterodimer formed by two different calcium-binding proteins (MRP8 and MRP14). Studies have identified that MRP8/14 regulates vascular inflammation and serves as a novel marker of acute coronary syndrome. In this study, we evaluated the correlation between serum levels of MRP8/14, hsCRP, endogenous secretory receptor for advanced glycation end-products (esRAGE) and the occurrence of coronary artery disease (CAD), or carotid intima-media thickness (IMT) when CAD was not yet developed in diabetic patients. Serum levels of MRP8/14, esRAGE and hsCRP were measured in 375 diabetic patients. Then the results of those who had CAD were compared against who had not. Also, we investigated the associations between above-mentioned indicators and IMT of subjects without CAD in both diabetic group and non-diabetic one. Serum MRP8/14 was significantly higher in CAD than in non-CAD group (9.7 ± 3.6 ug/ml vs. 8.2 ± 3.0 ug/ml, P < 0.001). It was associated with severity of CAD (r = 0.16, P = 0.026). In non-CAD group, MRP8/14 was associated with IMT in patients with (r = 0.30, P < 0.001) or without diabetes (r = 0.26, P = 0.015). The areas under the curves of receiver operating characteristic for CAD were 0.63 (95% CI 0.57-0.68) for MRP8/14, 0.76 (95% CI 0.71-0.81) for hsCRP and 0.62 (95% CI 0.56 -0.67) for esRAGE. In summary, we report that diabetic patients with CAD had elevated plasma MRP8/14 levels which were also positively correlated with the severity of CAD and carotid IMT in patients without clinically overt CAD.
Tài liệu tham khảo
Johansen OE, Birkeland KI: Preventing macrovascular disease in patients with type 2 diabetes mellitus. Am J Cardiovasc Drugs. 2003, 3 (4): 283-297. 10.2165/00129784-200303040-00007.
Lind L: Circulating markers of inflammation and atherosclerosis. Atherosclerosis. 2003, 169 (2): 203-214. 10.1016/S0021-9150(03)00012-1.
Ehrchen JM, Sunderkotter C, Foell D, Vogl T, Roth J: The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. Journal of leukocyte biology. 2009, 86 (3): 557-566. 10.1189/jlb.1008647.
Bouzidi F, Doussiere J: Binding of arachidonic acid to myeloid-related proteins (S100A8/A9) enhances phagocytic NADPH oxidase activation. Biochemical and biophysical research communications. 2004, 325 (3): 1060-1065. 10.1016/j.bbrc.2004.10.134.
Kerkhoff C, Nacken W, Benedyk M, Dagher MC, Sopalla C, Doussiere J: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2. Faseb J. 2005, 19 (3): 467-469.
Schenten V, Brechard S, Plancon S, Melchior C, Frippiat JP, Tschirhart EJ: iPLA(2), a novel determinant in Ca(2+)- and phosphorylation-dependent S100A8/A9 regulated NOX2 activity. Biochimica et biophysica acta. 1803 (7): 840-847.
Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J: Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nature medicine. 2007, 13 (9): 1042-1049. 10.1038/nm1638.
Ghavami S, Rashedi I, Dattilo BM, Eshraghi M, Chazin WJ, Hashemi M, Wesselborg S, Kerkhoff C, Los M: S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway. Journal of leukocyte biology. 2008, 83 (6): 1484-1492. 10.1189/jlb.0607397.
Polak JF: Carotid intima-media thickness: an early marker of cardiovascular disease. Ultrasound quarterly. 2009, 25 (2): 55-61. 10.1097/RUQ.0b013e3181a901ab.
Chen YS, Yan W, Geczy CL, Brown MA, Thomas R: Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis. Arthritis research & therapy. 2009, 11 (2): R39-10.1186/ar2645.
Ehlermann P, Eggers K, Bierhaus A, Most P, Weichenhan D, Greten J, Nawroth PP, Katus HA, Remppis A: Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products. Cardiovascular diabetology. 2006, 5: 6-10.1186/1475-2840-5-6.
Basta G: Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implications. Atherosclerosis. 2008, 196 (1): 9-21. 10.1016/j.atherosclerosis.2007.07.025.
Lu L, Pu LJ, Zhang Q, Wang LJ, Kang S, Zhang RY, Chen QJ, Wang JG, De Caterina R, Shen WF: Increased glycated albumin and decreased esRAGE levels are related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes. Atherosclerosis. 2009, 206 (2): 540-545. 10.1016/j.atherosclerosis.2008.12.045.
Yan XX, Lu L, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ, Shen WF: Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. Atherosclerosis. 2009, 205 (2): 544-548. 10.1016/j.atherosclerosis.2008.12.016.
Peng WH, Lu L, Hu J, Yan XX, Zhang Q, Zhang RY, Chen QJ, Shen WF: Decreased serum esRAGE level is associated with angiographically determined coronary plaque progression in diabetic patients. Clinical biochemistry. 2009, 42 (12): 1252-1259. 10.1016/j.clinbiochem.2009.04.017.
Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998, 15 (7): 539-553. 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.
Wang W, Peng W, Zhang X, Lu L, Zhang R, Zhang Q, Wang L, Chen Q, Shen W: Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients. Cardiovasc Diabetol. 2010, 9: 33-10.1186/1475-2840-9-33.
Berry C, L'Allier PL, Gregoire J, Lesperance J, Levesque S, Ibrahim R, Tardif JC: Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression. Circulation. 2007, 115 (14): 1851-1857. 10.1161/CIRCULATIONAHA.106.655654.
Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron. 1976, 16 (1): 31-41. 10.1159/000180580.
Foell D, Roth J: Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis and rheumatism. 2004, 50 (12): 3762-3771. 10.1002/art.20631.
Morrow DA, Wang Y, Croce K, Sakuma M, Sabatine MS, Gao H, Pradhan AD, Healy AM, Buros J, McCabe CH, Cannon CP, Braunwald E, Simon DI: Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial. American heart journal. 2008, 155 (1): 49-55. 10.1016/j.ahj.2007.08.018.
Miyamoto S, Ueda M, Ikemoto M, Naruko T, Itoh A, Tamaki S, Nohara R, Terasaki F, Sasayama S, Fujita M: Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina. Heart (British Cardiac Society). 2008, 94 (8): 1002-1007. 10.1136/hrt.2007.121640.
Altwegg LA, Neidhart M, Hersberger M, Muller S, Eberli FR, Corti R, Roffi M, Sutsch G, Gay S, von Eckardstein A, Wischnewsky MB, Luscher TF, Maier W: Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. European heart journal. 2007, 28 (8): 941-948. 10.1093/eurheartj/ehm078.
Frosch M, Vogl T, Seeliger S, Wulffraat N, Kuis W, Viemann D, Foell D, Sorg C, Sunderkotter C, Roth J: Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis. Arthritis and rheumatism. 2003, 48 (9): 2622-2626. 10.1002/art.11177.
Jung DY, Park JB, Lee EN, Lee HA, Joh JW, Kwon CH, Ki CS, Lee SY, Kim SJ: Combined use of myeloid-related protein 8/14 and procalcitonin as diagnostic markers for acute allograft rejection in kidney transplantation recipients. Transplant immunology. 2008, 18 (4): 338-343. 10.1016/j.trim.2007.10.004.
Ionita MG, Vink A, Dijke IE, Laman JD, Peeters W, van der Kraak PH, Moll FL, de Vries JP, Pasterkamp G, de Kleijn DP: High levels of myeloid-related protein 14 in human atherosclerotic plaques correlate with the characteristics of rupture-prone lesions. Arteriosclerosis, thrombosis, and vascular biology. 2009, 29 (8): 1220-1227. 10.1161/ATVBAHA.109.190314.
Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI: Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation. 2009, 120 (5): 427-436. 10.1161/CIRCULATIONAHA.108.814582.
Bouma G, Lam-Tse WK, Wierenga-Wolf AF, Drexhage HA, Versnel MA: Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. Diabetes. 2004, 53 (8): 1979-1986. 10.2337/diabetes.53.8.1979.
Burkhardt K, Schwarz S, Pan C, Stelter F, Kotliar K, Von Eynatten M, Sollinger D, Lanzl I, Heemann U, Baumann M: Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy. Cardiovascular diabetology. 2009, 8: 10-10.1186/1475-2840-8-10.
Lundby-Christensen L, Almdal TP, Carstensen B, Tarnow L, Wiinberg N: Carotid intima-media thickness in individuals with and without type 2 diabetes: a reproducibility study. Cardiovascular diabetology. 2010, 9: 40-10.1186/1475-2840-9-40.
Yonekura H, Yamamoto Y, Sakurai S, Petrova RG, Abedin MJ, Li H, Yasui K, Takeuchi M, Makita Z, Takasawa S, Okamoto H, Watanabe T, Yamamoto H: Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. The Biochemical journal. 2003, 370 (Pt 3): 1097-1109.
Koyama H, Yamamoto H, Nishizawa Y: RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases. Molecular medicine (Cambridge, Mass. 2007, 13 (11-12): 625-635.