Increased peripheral stem cell pool in MDS: an indication of disease progression?

Bennett, 1982, Co-operative group, proposals for the classification of the myelodysplastic syndromes, Br. J. Haematol., 51, 189, 10.1111/j.1365-2141.1982.tb08475.x Socinsky, 1988, Granulocyte-macrophage colony stimulating factor expands the circulating haematopoietic progenitor cell compartment in man, Lancet, 28, 1194, 10.1016/S0140-6736(88)92012-0 Fuchigami, 2000, Absolute number of circulating CD34+ cells is abnormally low in refractory anemias and extremely high in RAEB and RAEB-t; novel pathological features of myelodysplastic syndromes identified by highly sensitive cytometry, Leukemia Res., 24, 163, 10.1016/S0145-2126(99)00167-8 Sawada, 1995, Proliferation and differentiation of myelodysplastic CD34+ cells: phenotypic subpopulations of marrow CD34+ cells, Blood, 1, 194, 10.1182/blood.V85.1.194.bloodjournal851194 Fontenay-Roupie, 1999, Ineffective erythropoiesis in myelodysplastic syndromes: correlation with Fas expression but not with lack of erythropoietin receptor signal transduction, Br. J. Haematol., 106, 464, 10.1046/j.1365-2141.1999.01539.x Delforge, 1995, Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes, Blood, 86, 3660, 10.1182/blood.V86.10.3660.bloodjournal86103660 Podesta, 1997, Spontaneous exodus of normal early progenitor cells (Ph-negative LTC-IC) in the peripheral blood of patients with chronic myeloid leukaemia at the beginning of the disease, Br. J. Haematol., 97, 94, 10.1046/j.1365-2141.1997.d01-2128.x Mundle, 1999, Correlation of tumor necrosis factor alpha (TNF) with high Caspase 3-like activity in myelodysplastic syndromes, Cancer Lett., 140, 201, 10.1016/S0304-3835(99)00072-5 Allampallam, 1999, Measurement of mRNA expression for a variety of cytokines and its receptors in bone marrows of patients with myelodysplastic syndromes, Anticancer Res., 19, 5323 Raymakers, 1994, Prognostic implication of bone marrow culturing in myelodysplastic syndrome: a retrospective analysis, Leuk. Lymphoma, 14, 111, 10.3109/10428199409049656