Increased penetration of diphenhydramine in brain via proton-coupled organic cation antiporter in rats with lipopolysaccharide-induced inflammation

Brain, Behavior, & Immunity - Health - Tập 10 - Trang 100188 - 2021
Atsushi Kawase1, Taihei Chuma1, Kota Irie1, Akira Kazaoka1, Asuka Kakuno1, Naoya Matsuda1, Hiroaki Shimada1, Masahiro Iwaki1,2,3
1Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka, Japan
2Pharmaceutical Research and Technology Institute, Kindai University, Osaka, Japan
3Antiaging Center, Kindai University, Osaka, Japan

Tài liệu tham khảo

Assmann, 2017, Isolation and cultivation of primary brain endothelial cells from adult mice, BIO-PROTOCOL, 7, 10.21769/BioProtoc.2294 Au-Yeung, 2006, A pharmacokinetic study of diphenhydramine transport across the blood-brain barrier in adult sheep: potential involvement of a carrier-mediated mechanism, Drug Metab. Dispos., 34, 955, 10.1124/dmd.105.007898 Auvity, 2017, Diphenhydramine as a selective probe to study H + -antiporter function at the blood–brain barrier: application to [ 11 C]diphenhydramine positron emission tomography imaging, J. Cerebr. Blood Flow Metabol., 37, 2185, 10.1177/0271678X16662042 Bauer, 2007, Tumor necrosis factor α and endothelin-1 increase p-glycoprotein expression and transport activity at the blood-brain barrier, Mol. Pharmacol., 10.1124/mol.106.029512 Bolder, 2006, Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms, Cell Stress Chaperones, 11, 89, 10.1379/CSC-143R.1 Bouw, 1998, Methodological aspects of the use of a calibrator in in vivo microdialysis-further development of the retrodialysis method, Pharm. Res. (N. Y.), 15, 1673, 10.1023/A:1011992125204 Calsolaro, 2016, Neuroinflammation in Alzheimer’s disease: current evidence and future directions, Alzheimer’s Dementia, 12, 719, 10.1016/j.jalz.2016.02.010 Chapy, 2015, Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line, Br. J. Pharmacol., 10.1111/bph.13258 Cherrington, 2004, Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats, Drug Metab. Dispos., 32, 734, 10.1124/dmd.32.7.734 Diao, 2010, Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-α, IL-6, and IL-1β, J. Biol. Chem., 10.1074/jbc.M110.107805 DILL, 1949, Biochemical studies on diphenhydramine (benadryl) chemical determination of diphenhydramine, J. Biol. Chem., 179, 395, 10.1016/S0021-9258(18)56849-6 Donner, 2004, Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS, Biol. Chem., 385, 10.1515/BC.2004.029 Fisher, 2009, Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats, Eur. J. Pharmacol., 613, 119, 10.1016/j.ejphar.2009.04.002 Foster, 1993, Production of TNF alpha by LPS-stimulated murine, rat and human blood and its pharmacological modulation, Agents Actions, 38, C77, 10.1007/BF01991143 Gasser, 2017, Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice, Brain Struct. Funct., 222, 1913, 10.1007/s00429-016-1315-9 Geier, 2013, Profiling solute carrier transporters in the human blood-brain barrier, Clin. Pharmacol. Ther., 10.1038/clpt.2013.175 Gengo, 1989, The pharmacodynamics of diphenhydramine-induced drowsiness and changes in mental performance, Clin. Pharmacol. Ther., 45, 15, 10.1038/clpt.1989.3 Goralski, 2002, The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules, J. Pharmacol. Exp. Therapeut., 303, 959, 10.1124/jpet.102.038885 Hartmann, 2002, Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia, J. Pharmacol. Exp. Therapeut., 303, 273, 10.1124/jpet.102.039404 Hartmann, 2005, Impact of endotoxin-induced changes in P-glycoprotein expression on disposition of doxorubicin in mice, Drug Metab. Dispos., 33, 820, 10.1124/dmd.104.002568 Hayer-Zillgen, 2002, Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3, Br. J. Pharmacol., 10.1038/sj.bjp.0704785 Heneka, 2015, Neuroinflammation in Alzheimer’s disease, Lancet Neurol., 14, 388, 10.1016/S1474-4422(15)70016-5 Higuchi, 2015, Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model, Drug Metabol. Pharmacokinet., 30, 182, 10.1016/j.dmpk.2014.12.006 Ito, 2010, Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine, J. Pharmacol. Exp. Therapeut., 10.1124/jpet.109.163642 Kang, 2006, Neurotoxic pyridinium metabolites OF haloperidol are substrates OF human organic cation transporters, Drug Metab. Dispos., 34, 1145, 10.1124/dmd.105.009126 Kato, 2010, Effects of lipopolysaccharide on P-glycoprotein expression and activity in the liver and kidneys, Eur. J. Pharmacol., 636, 155, 10.1016/j.ejphar.2010.03.024 Kato, 2008, Changes of midazolam pharmacokinetics in Wistar rats treated with lipopolysaccharide: relationship between total CYP and CYP3A2, Innate Immun., 10.1177/1753425908095956 Kawase, 2008, Differences in cytochrome P450 and nuclear receptor mRNA levels in liver and small intestines between SD and DA rats, Drug Metabol. Pharmacokinet., 23, 196, 10.2133/dmpk.23.196 Kawase, 2019, Changes in transporters and metabolizing enzymes in the livers of rats with bile duct ligation, J. Pharm. Pharmaceut. Sci., 22, 457 Kawase, 2014, Distinct alterations in ATP-binding cassette transporter expression in liver, kidney, small intestine, and brain in adjuvant-induced arthritic rats, J. Pharmacol. Sci., 103, 2556, 10.1002/jps.24043 Kawase, 2018, Profiling of hepatic metabolizing enzymes and nuclear receptors in rats with adjuvant arthritis by targeted proteomics, Biopharm Drug Dispos., 39, 308, 10.1002/bdd.2147 Kitamura, 2014, Transport characteristics of tramadol in the blood–brain barrier, J. Pharmacol. Sci., 103, 3335, 10.1002/jps.24129 Kitamura, 2016, Cocktail-dosing microdialysis study to simultaneously assess delivery of multiple organic-cationic drugs to the brain, J. Pharmacol. Sci., 105, 935, 10.1002/jps.24691 Köppel, 1987, Clinical symptomatology of diphenhydramine overdose: an evaluation of 136 cases in 1982 to 1985, J. Toxicol. Clin. Toxicol., 25, 53, 10.3109/15563658708992613 Kubo, 2013, Propranolol transport across the inner blood–retinal barrier: potential involvement of a novel organic cation transporter, J. Pharmacol. Sci., 102, 3332, 10.1002/jps.23535 Kurosawa, 2017, Involvement of proton-coupled organic cation antiporter in varenicline transport at blood-brain barrier of rats and in human brain capillary endothelial cells, J. Pharmacol. Sci., 106, 2576, 10.1016/j.xphs.2017.04.032 Kurosawa, 2018, Expression and functional characterization of drug transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells, Mol. Pharm., 15, 5546, 10.1021/acs.molpharmaceut.8b00697 Kuwayama, 2008, Uptake of 3,4-methylenedioxymethamphetamine and its related compounds by a proton-coupled transport system in Caco-2 cells, Biochim. Biophys. Acta Biomembr., 1778, 42, 10.1016/j.bbamem.2007.08.023 Lee, 2012, Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats, BMB Rep, 45, 371, 10.5483/BMBRep.2012.45.6.018 Lin, 2010, Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents, J. Neurochem., 114, 717, 10.1111/j.1471-4159.2010.06801.x Liu, 2015, Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice, Sci. Rep., 5, 13558, 10.1038/srep13558 Luo, 2014, Transcriptional regulation of the human, porcine and bovine OCTN2 gene by PPARα via a conserved PPRE located in intron 1, BMC Genet., 10.1186/s12863-014-0090-y Luster, 1994, Endotoxin-induced cytokine gene expression and excretion in the liver, Hepatology, 10.1002/hep.1840190229 McKenna, 2018, Immunotolerant p50/NFκB signaling and attenuated hepatic IFNβ expression increases neonatal sensitivity to endotoxemia, Front. Immunol., 9, 2210, 10.3389/fimmu.2018.02210 Miller, 2008, Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy, Pharmacol. Rev., 10.1124/pr.107.07109 Morimoto, 2008, Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein, Drug Metab. Dispos., 36, 6, 10.1124/dmd.107.017699 Nakazawa, 2010, Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect, J. Pharmacol. Sci., 99, 467, 10.1002/jps.21807 Nežić, 2009, Effect of simvastatin on proinflammatory cytokines production during lipopolysaccharide-induced inflammation in rats, Gen. Physiol. Biophys. Nicholson, 1983, Antihistamines and sedation, Lancet (London, England), 2, 211, 10.1016/S0140-6736(83)90185-X Nie, 2005, Transcriptional regulation of murine Slc22a1 (Oct1) by peroxisome proliferator agonist receptor-α and -γ, Am. J. Physiol. Gastrointest. Liver Physiol., 10.1152/ajpgi.00057.2004 Okura, 2008, Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone, Drug Metab. Dispos., 36, 10.1124/dmd.108.022087 Okura, 2007, Blood–brain barrier transport of pramipexole, a dopamine D2 agonist, Life Sci., 80, 1564, 10.1016/j.lfs.2007.01.035 Oldendorf, 1981, Clearance of radiolabeled substances by brain after arterial injection using a diffusible internal standard Oldendorf, 1970, Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard, Brain Res., 24, 372, 10.1016/0006-8993(70)90123-X Ose, 2008, P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier, Drug Metab. Dispos., 36, 427, 10.1124/dmd.107.018556 Pavese, 2006, Microglial activation correlates with severity in Huntington disease: a clinical and PET study, Neurology, 66, 1638, 10.1212/01.wnl.0000222734.56412.17 Perry, 2012, Innate inflammation in Parkinson’s disease, Cold Spring Harb. Perspect. Med., 2, a009373, 10.1101/cshperspect.a009373 Poller, 2010, Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier, Cell. Mol. Neurobiol., 10.1007/s10571-009-9431-1 Qin, 2007, Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration, Glia, 55, 453, 10.1002/glia.20467 S, 2017, Hydroalcoholic extract of Stevia rebaudiana bert. leaves and stevioside ameliorates lipopolysaccharide induced acute liver injury in rats, Biomed. Pharmacother., 10.1016/j.biopha.2017.08.082 S, 2009, Penetration of oseltamivir and its active metabolite into the brain after lipopolysaccharide-induced inflammation in mice, J. Pharm. Pharmacol., 61 Sadiq, 2011, Diphenhydramine active uptake at the blood–brain barrier and its interaction with oxycodone in vitro and in vivo, J. Pharmacol. Sci., 100, 3912, 10.1002/jps.22567 Shaffer, 2014, Diphenhydramine has similar interspecies net active influx at the blood-brain barrier, J. Pharmacol. Sci., 10.1002/jps.23927 Shebl, 2010, Comparison of mRNA and protein measures of cytokines following vaccination with human papillomavirus-16 L1 virus-like particles, Cancer Epidemiol. Biomark. Prev., 19, 978, 10.1158/1055-9965.EPI-10-0064 Shimomura, 2013, Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model, Fluids Barriers CNS, 10, 8, 10.1186/2045-8118-10-8 Somann, 2019, Characterization of plasma cytokine response to intraperitoneally administered LPS & subdiaphragmatic branch vagus nerve stimulation in rat model, PloS One, 14, 10.1371/journal.pone.0214317 Spector, 1988, Transport of amantadine and rimantadine through the blood-brain barrier, J. Pharmacol. Exp. Therapeut., 244, 516 Sung, 2004, Modulation of PPAR in aging, inflammation, and calorie restriction, Journals Gerontol. Ser. A Biol. Sci. Med. Sci., 10.1093/gerona/59.10.B997 Suzuki, 2016, Involvement of a proton-coupled organic cation antiporter in the blood-brain barrier transport of amantadine, Biopharm Drug Dispos., 37, 323, 10.1002/bdd.2014 Uno, 2007, Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis, Drug Metabol. Pharmacokinet., 22, 313, 10.2133/dmpk.22.313 Virdis, 2005, Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress, J. Pharmacol. Exp. Therapeut., 10.1124/jpet.104.077644 Vos, 1997, Differential effects of nitric oxide synthase inhibitors on endotoxin- induced liver damage in rats, Gastroenterology, 113, 1323, 10.1053/gast.1997.v113.pm9322528 Wang, 2017, Pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter for brain-specific drug delivery, J. Contr. Release, 254, 34, 10.1016/j.jconrel.2017.03.034 Wedn, 2020, Nicotine improves survivability, hypotension, and impaired adenosinergic renal vasodilations in endotoxic rats: role of α7-nAChRs/HO-1 pathway, Shock, 53, 503, 10.1097/SHK.0000000000001384 Wedn, 2020, Time and sex dependency of hemodynamic, renal, and survivability effects of endotoxemia in rats, Saudi Pharmaceut. J., 28, 127, 10.1016/j.jsps.2019.11.014 Wen, 2010, Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor α (PPARα) via a PPRE located in the first intron, Biochem. Pharmacol., 10.1016/j.bcp.2009.10.002 Wright, 2004, Functional map of TEA transport activity in isolated rabbit renal proximal tubules, Am. J. Physiol. Ren. Physiol., 287, F442, 10.1152/ajprenal.00115.2004 Yao, 1997, Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors, J. Biol. Chem., 272, 17795, 10.1074/jbc.272.28.17795 Yu, 2007, TNF activates P-glycoprotein in cerebral microvascular endothelial cells, Cell. Physiol. Biochem., 20, 853, 10.1159/000110445