Increased odds of disordered eating in polycystic ovary syndrome: a systematic review and meta-analysis

Iris Lee1, Laura G. Cooney2, Shailly Saini2, Mary D. Sammel2,3, Kelly C. Allison4, Anuja Dokras2
1Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
2Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, USA
3Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
4Center for Weight and Eating Disorders, University of Pennsylvania, Philadelphia, USA

Tóm tắt

We aimed to identify the risk of eating disorders (ED) in women with polycystic ovary syndrome (PCOS) compared to controls. We performed a systematic review and meta-analysis of studies that included women with well-defined PCOS and controls and used validated ED screening/diagnostic tools to measure mean ED score, prevalence of abnormal ED scores, and/or prevalence of specific ED diagnoses such as bulimia nervosa and binge eating disorder. Eight studies, including 470 women with PCOS and 390 controls, met inclusion criteria for the systematic review. Meta-analysis of seven of those studies found that the odds of an abnormal ED score (OR 3.05; 95% CI 1.33, 6.99; four studies) and the odds of any ED diagnosis (OR 3.87; 95% CI 1.43, 10.49; four studies) were higher in women with PCOS compared to controls. Our study suggests that women with PCOS are at increased odds of having abnormal ED scores and specific ED diagnoses. Given the potential implications of an ED on weight management strategies, our findings support routine screening for ED in this population. Level I, systematic review and meta-analysis.

Tài liệu tham khảo

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