Increased levels of irisin in people with long‐standing Type 1 diabetes

Diabetic Medicine - Tập 32 Số 9 - Trang 1172-1176 - 2015
Daniel Espes1,2, Joey Lau1, Per‐Ola Carlsson1,2
1Departments of Medical Cell Biology, Uppsala University, Sweden
2Departments of Medical Sciences, Uppsala University, Sweden

Tóm tắt

AbstractBackgroundIrisin stimulates browning of white adipose tissue and improves metabolic control in mice. Betatrophin, another recently described hormone, improves metabolic control in mice by inducing β–cell proliferation. In vitro, irisin stimulates the expression of betatrophin in rat adipocytes. There is a great interest in developing drugs that target or use these hormones for the treatment of obesity and diabetes. We have previously reported on increased levels of betatrophin in people with Type 1 diabetes, but the levels of irisin are currently unknown.AimTo characterize the levels of irisin in Type 1 diabetes and investigate a potential correlation with betatrophin.MethodsIrisin and betatrophin were measured by enzyme‐linked immunosorbant assay (ELISA) in 45 individuals with Type 1 diabetes and in 25 healthy controls.ResultsIrisin levels were increased in people with Type 1 diabetes, and especially in women. Negative correlations between irisin levels and age at onset of Type 1 diabetes and plasma triacylglycerol levels were observed. Interestingly, in women with Type 1 diabetes a negative correlation between irisin and insulin doses was also observed. When computing correlations for all study participants, a positive correlation between irisin and total betatrophin was observed, but not between irisin and full‐length betatrophin.ConclusionWe report on increased circulating levels of irisin in people with Type 1 diabetes, especially in women. For women with Type 1 diabetes, the levels of irisin correlated with lower insulin requirements. Further studies are clearly needed to determine the role of irisin in Type 1 diabetes.

Từ khóa


Tài liệu tham khảo

10.1038/nature10777

10.1371/journal.pone.0060563

10.1016/j.metabol.2012.09.002

10.1210/jc.2012-2749

10.1016/j.diabres.2013.01.007

10.1016/j.jdiacomp.2013.03.002

10.1016/j.cell.2013.04.008

10.1155/2014/323407

Fu Z, 2014, Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity, Sci Rep [Research Support, Non‐U.S. Gov't], 4, 5013

10.1007/s00125-014-3208-x

10.1007/s00125-013-3071-1

10.2337/db13-1106

10.4161/adip.27370

10.1210/jc.2014-1367

10.1007/s00125-014-3346-1

Dave GS, 2007, Hyperglycemia induced oxidative stress in type‐1 and type‐2 diabetic patients with and without nephropathy, Cell Mol Biol (Noisy‐le‐grand), 53, 68

10.1016/j.diabres.2004.11.005

10.1016/B978-0-12-411619-1.00008-2

10.2337/db11-0510

Thông tin
Thông tin xuất bản

Diabetic Medicine

Tập 32 Số 9

1172-1176

Thông tin tác giả