Increased fetal nuchal translucency: possible involvement of early cardiac failure

Wiley - Tập 10 Số 4 - Trang 265-268 - 1997
Nuno Montenegro1, Alexandra Matias1, José Carlos Areias2, Sérgio Castedo3, Hervé Barré4
1Ultrasound Unit, Department of Obstetrics and Gynecology, University Hospital of S.João, Porto, Portugal
2Pediatric Cardiology Unit, University Hospital of S.João, Porto, Portugal
3IPATIMUP, University of Porto, Portugal
4Epidemiology Department, University Hospital of S.João, Porto, Portugal

Tóm tắt

AbstractThe ultrasonographic measurement of nuchal translucency thickness at 10–23 weeks of gestation is accepted as an efficient method of screening for chromosomal abnormalities. However, the underlying mechanism producing increased nuchal translucency thickness is still poorly understood. The purpose of this study was to investigate the possible contribution of impaired cardiac function to such an increase, by studying the venous return in the ductus venosus, using Doppler ultrasound.In a total of 6.5 fetuses, nuchal translucency thickness was measured at 10–13 weeks of gestation by means of a transvaginal probe. Color‐coded and pulsed Doppler ultra‐sound were also used to evaluate different hemodynamic parameters in the ductus venosus: maximum systolic and diastolic velocities, pulsatility index, lowest forward velocity during atria1 contraction and fetal heart rate.Fetal nuchal translucency thickness of ≥ 3 mm was found in 17 cases; in five of them there were chromosomal anomalies: four trisomy 21 and one trisomy 18. Of interest is the finding that in the five chromosomally abnormal fetuses with increased nuchal translucency thickness, the forward velocity during atria1 contraction was consistently less than 2 cm/s (p < 0.001).This impairment of atria1 contraction may well implicate cardiac failure and/or heart defects in the pathogenesis of increased nuchal translucency thickness in the first trimester of pregnancy. Furthermore, nuchal translucency may prove to be a sensitive marker of the early identification of fetal cardiac anomalies. Copyright © 1997 International Society of Ultrasound in Obstetrics and Gynecology

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Wiley

Tập 10 Số 4

265-268

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