Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer

Journal of Surgical Oncology - Tập 100 Số 5 - Trang 382-386 - 2009
Yan‐Bo Chen1, Chunfan Jiang2, Guo‐Qiang Zhang1, Jinsong Wang1, Da Pang1
1Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, PR China.
2The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas

Tóm tắt

AbstractBackground and ObjectivesHyaluronic acid binding protein 1 (HABP1), a family of proteins interacting with hyaluronan (HA), had been associated with cell adhesion and tumor invasion. The aim of this study was to investigate the correlation between clinicopathologic factors and patient survival time with the expression of HABP1 in breast cancer patients.MethodsExpression of HABP1 mRNA and protein were detected with real‐time quantitative PCR and immunohistochemical staining in 63 breast cancer and non‐cancerous matched tissues.ResultsThe mRNA expression level of HABP1 was unrelated to the patient's age, tumor size, histological grade, TNM stage. However, it proved to be positively related to axillary nodes metastasis (P = 0.008). Furthermore, it was shown that the survival rate of patients with low HABP1 expression was significantly higher than that of patients with high HABP1 expression (P = 0.025). Multivariate analysis revealed that HABP1 mRNA expression level was a significant factor for predicting prognosis (P = 0.022). The immunohistochemistry results showed that the expression level of HABP1 in breast cancer cells was higher than that in normal breast cells.ConclusionHABP1 might be an independent predictive factor for breast cancer prognosis and up‐regulation of HABP1 might play an important role in the metastasis of breast cancer. J. Surg. Oncol. 2009;100:382–386. © 2009 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

10.1097/PPO.0b013e318074dc6f

10.1038/nrc1391

10.1074/jbc.M202404200

10.1016/S0002-9440(10)64757-8

Gupta S, 1991, Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface, Eur J Cell Biol, 56, 58

10.1016/0014-4827(91)90388-B

10.1002/mrd.1080380112

Rao CM, 1996, Hyaluronic acid induced hyaluronic acid binding protein phosphorylation and inositol triphosphate formation in lymphocytes, Biochem Mol Biol Int, 40, 327

10.1016/S0304-4165(97)00049-4

10.1054/bjoc.2000.1330

10.1002/ijc.20105

10.1023/B:MCBI.0000049362.04033.ea

10.1158/0008-5472.CAN-07-6752

10.1006/geno.1998.5364

10.1074/jbc.271.4.2206

10.1016/S0378-1119(97)00035-8

10.1016/0092-8674(91)90627-B

10.1084/jem.179.6.1809

10.1007/s004180000191

10.1006/bbrc.2001.4473

10.1038/sj.cr.7290284

10.1016/j.yexcr.2007.10.033

10.1016/j.imbio.2006.11.011

10.1016/S0006-291X(02)02788-2

10.1038/sj.cdd.4401418

10.1007/s10495-006-5396-4

10.1101/gad.1211604

10.1016/j.cub.2006.04.042

10.1083/jcb.200612022

10.1016/S0171-2985(98)80029-6

10.1006/clin.1997.4374

10.1074/jbc.M110711200

10.1073/pnas.0403317101

10.1021/bc800077y

Thông tin
Thông tin xuất bản

Journal of Surgical Oncology

Tập 100 Số 5

382-386

Thông tin tác giả