Increased catabolism of muscle proteins as a manifestation of radiation myopathy
Tóm tắt
Exposure of the hindquarter of the rat to 1000 rad of gamma-radiation caused a significant increase in the release of glutamine and alanine into the perfusion fluid at 4 h post-irradiation. The extent of the release of glutamine exceeded that of alanine. Furthermore, the exposure to gamma-radiation brought about a significant lowering of the intra-/extracellular concentration gradient with respect to glutamine and alanine.
Tài liệu tham khảo
Alpert NL (1976) Model 23 AM glucose analyzer. Lab World 27:8–13
Altman KI, Gerber GB (1983) The effects of ionizing radiation on connective tissue. Adv Radiat Biol 10:237–304
Altman KI, Gerber GB, Hempelmann LH (1959) Radiation-induced tissue breakdown and its relation to protein catabolism. Int J Radiat Biol (Suppl) 26–32
Bergmeyer HU, Bernt E, Schmidt F, Stork H (1974) D-Glucose: Bestimmung mit Hexokinase and Glucose-6-phosphat-Dehydrogenase. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd edn, pp 1241–1246
Bergström RM, Salmi A (1962) Radiation-induced damage in the ultrastructure of striated muscle. Exp Cell Res 26:226–228
Bernt E, Bergmeyer HU (1974) L-Glutamat: UV-Test mit Glutamat-Dehydrogenase and NAD. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd Edn, pp 1749–1753
Clerbaux T, Gerets G, Frans A (1973) Oxygen content determination using a new analyzer. J Lab Clin Med 82:342–348
Cohen PP (1957) Suspending media for animal tissues. In: Umbreit WW, Burris RH, Stauffer JF (eds) Manometric Techniques, pp 147–150. Burgess, Minneapolis
Darden EB Jr (1960) Changes in membrane potential, K content, and fiber structure in irradiated frog sartorius muscle. Am J Physiol 198:709–714
Eggstein M, Kuhlmann E (1974) Triglyceride and Glycerin. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd Edn, pp 1871–1878
Fedder L, Hellner H (1982) Die Veränderungen der quergestreiften Muskulatur nach Röntgenbestrahlung im Tierexperiment. Strahlentherapie 30:682–706
Gerber G, Gerber G, Altman KI, Hempelman LH (1959) Radiation-induced tissue breakdown. IV. The source of degraded amino acids in irradiated rats. Int J Radiat Biol 12:277–287
Gerber GB, Gerber G, Gertler P, Altman KI, Hempelmann LH (1961 a) Dose dependency of radiation-induced creatine excretion in rat urine. Radiat Res 15:307–313
Gerber GB, Gerber G, Gertler P, Altman KI, Hempelmann LH (1961 b) Creatine metabolism after X-irradiation of rats. Int J Radiat Biol 3:17–22
Gerber GB, Gerber G, Altman KI (1962) The mechanism of radiation-induced creatinuria. Proc Soc Exp Biol Med 110:797–799
Gerstner BB, Lewis RB, Ritchey EO (1954) Early effects of high intensity X-irradiation on skeletal muscle. J Gen Physiol 37:445–459
Gutmann I, Wahlefeld AW (1974) L (+) Lactat: Bestimmung mit Lactat-Dehydrogenase und NAD. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd Edn, pp 1510–1514
Haberland GL, Schreier K, Bruns F, Altman KI, Hempelmann LH (1955) Creatine-creatinine metabolism in radiation myopathy. Nature 175:1039–1040
Haberland GL, Schreier K, Altman KI, Hempelmann LH (1957) Cellular destruction and protein breakdown induced by exposure to x-rays. II. Further studies using the concept of the dynamic glycine pool. Biochim Biophys Acta 25:237–241
Jaworek D, Gruber W, Bergmeyer HU (1974) Adenosin-5′-diphosphat and Adenosin-5′-monophosphat. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd Edn, pp 2178–2181
Khan MY (1974) Radiation-induced changes in skeletal muscle. J Neuropathol Exp Neurol 33:42–57
Klewitz F (1923) Kurze Mitteilung über einige Stoffwechseluntersuchungen bei Röntgenbestrahlten. (Kreatinin-Kreatin-Aminosäuren- und Stickstoffausscheidung.) Strahlentherapie 14:101–105
Kurohara SS, Rubin P, Hempelmann LH (1961) Creatinuria and fatigue in patients undergoing radiation therapy. Radiology 77:804–812
Lamprecht W, Stein P, Heinz F, Weisser H (1974) Creatinphosphat: Bestimmung mit CreatinKinase, Hexokinase and Glucose-6-phosphat-Dehydrogenase. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd edn, pp 1825–1829
Lauenstein K, Haberland GL, Hempelmann LH, Altman KI (1957) Cellular destruction and protein breakdown induced by exposure to x-rays. III. The use of hippuric acids for the simultaneous estimate of 2 “free” amino acid pools. Biochim Biophys Acta 26:421–424
Lewis RB (1954) Changes in striated muscle following single intense doses of X-rays. Lab Invest 3:48–55
Lund P (1974) L-Glutamin: Bestimmung mit Glutaminase and Glutamat-Dehydrogenase. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd edn, pp 1767–1769
Preedy VR, Garlick PJ (1981) Rates of protein synthesis in skin and bone, and their importance in the assessment of protein degradation in the perfused rat hemicorpus. Biochem J 194:373–376
Ruderman NB, Houghton CRS, Hems R (1971) Evaluation of the isolated perfused rat hind-quarter for the study of muscle metabolism. Biochem J 124:639–651
Schwenen M (1981) Skelettmuskulatur und metabolische Homöostase: Physiologische und pathophysiologische Aspekte der Glucocorticoidwirkung auf den Muskelstoffwechsel. Habilitationsschrift, Universität Düsseldorf
Seifter S, Dayton S, Novic B, Muntwyler E (1950) The estimation of glycogen with the anthrone reagent. Arch Biochem 25:191–200
Shimizu S, Tani Y, Yamada H, Tabata M, Murachi T (1980) Enzymatic determination of serum free fatty acids: A colorimetric method. Anal Biochem 107:193–198
Szasz G, Gruber W, Bernt E (1976) Creatine Kinase in Serum. 1. Determination of optimum reaction conditions. Clin Chem 22:650–656
Warren S (1943) Effects of radiation on normal tissues XIV. Effects on striated muscle. Arch Pathol 35:347–349
Williamson DH (1974) L-Alanin: Bestimmung mit Alanin-Dehydrogenase. In: Bergmeyer HU (ed) Methoden der enzymatischen Analyse, Vol II, 3rd edn. pp 1724–1727
Wollenberger A, Ristau O, Schoffa G (1960) Eine einfache Technik der extrem schnellen Abkühlung größerer Gewebestücke. Pflügers Arch 270:399–412