Increased and Prolonged Pulmonary Fibrosis in Surfactant Protein C-Deficient Mice Following Intratracheal Bleomycin

The American Journal of Pathology - Tập 167 - Trang 1267-1277 - 2005
William E. Lawson1,2, Vasiliy V. Polosukhin1, Georgios T. Stathopoulos1, Ornella Zoia1, Wei Han1, Kirk B. Lane1, Bo Li1, Edwin F. Donnelly3, George E. Holburn3, Kenneth G. Lewis3, Robert D. Collins4, William M. Hull5, Stephan W. Glasser5, Jeffrey A. Whitsett5, Timothy S. Blackwell1,2,6
1Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
2Department of Veterans Affairs Medical Center, Nashville, Tennessee
3Division of Allergy, Pulmonary, and Critical Care Medicine, and the Departments of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee
4Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee
5Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
6Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee

Tài liệu tham khảo

Gross, 2001, Idiopathic pulmonary fibrosis, N Engl J Med, 345, 517, 10.1056/NEJMra003200 American Thoracic Society, 2000, Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS), Am J Respir Crit Care Med, 161, 646, 10.1164/ajrccm.161.2.ats3-00 Marshall, 1997, The pathogenesis of pulmonary fibrosis: is there a fibrosis gene?, Int J Biochem Cell Biol, 29, 107, 10.1016/S1357-2725(96)00141-0 Marshall, 2000, Adult familial cryptogenic fibrosing alveolitis in the United Kingdom, Thorax, 55, 143, 10.1136/thorax.55.2.143 Bitterman, 1986, Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members, N Engl J Med, 314, 1343, 10.1056/NEJM198605223142103 Hodgson, 2002, Nationwide prevalence of sporadic and familial idiopathic pulmonary fibrosis: evidence of founder effect among multiplex families in Finland, Thorax, 57, 338, 10.1136/thorax.57.4.338 Nogee, 2001, A mutation in the surfactant protein C gene associated with familial interstitial lung disease, N Engl J Med, 344, 573, 10.1056/NEJM200102223440805 Amin, 2001, Surfactant protein deficiency in familial interstitial lung disease, J Pediatr, 139, 85, 10.1067/mpd.2001.114545 Nogee, 2002, Mutations in the surfactant protein C gene associated with interstitial lung disease, Chest, 121, 20S, 10.1378/chest.121.3_suppl.20S Thomas, 2002, Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred, Am J Respir Crit Care Med, 165, 1322, 10.1164/rccm.200112-123OC Weaver, 1998, Synthesis, processing and secretion of surfactant proteins B and C, Biochim Biophys Acta, 1408, 173, 10.1016/S0925-4439(98)00066-0 Beers, 2005, Surfactant protein C biosynthesis and its emerging role in conformational lung disease, Annu Rev Physiol, 67, 663, 10.1146/annurev.physiol.67.040403.101937 Lazo, 1990, Bleomycin: a pharmacologic tool in the study of the pathogenesis of interstitial pulmonary fibrosis, Pharmacol Ther, 47, 347, 10.1016/0163-7258(90)90061-6 Bowden, 1984, Unraveling pulmonary fibrosis: the bleomycin model, Lab Invest, 50, 487 Phan, 1992, Lung cytokine production in bleomycin-induced pulmonary fibrosis, Exp Lung Res, 18, 29, 10.3109/01902149209020649 Zhang, 1994, Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study, Am J Pathol, 145, 114 Glasser, 2001, Altered stability of pulmonary surfactant in SP-C-deficient mice, Proc Natl Acad Sci USA, 98, 6366, 10.1073/pnas.101500298 Strutz, 1995, Identification and characterization of a fibroblast marker: FSP1, J Cell Biol, 130, 393, 10.1083/jcb.130.2.393 Lawson, 2005, Characterization of fibroblast-specific protein 1 in pulmonary fibrosis, Am J Respir Crit Care Med, 171, 899, 10.1164/rccm.200311-1535OC Hoff, 1999, Elastin gene expression is upregulated during pulmonary fibrosis, Connect Tissue Res, 40, 145, 10.3109/03008209909029110 Blackwell, 1999, Chemotactic gradients predict neutrophilic alveolitis in endotoxin-treated rats, Am J Respir Crit Care Med, 159, 1644, 10.1164/ajrccm.159.5.9806166 Pryhuber, 1991, Ontogeny of surfactant proteins A and B in human amniotic fluid as indices of fetal lung maturity, Pediatr Res, 30, 597, 10.1203/00006450-199112000-00023 Akinbi, 1997, Rescue of SP-B knockout mice with a truncated SP-B proprotein. Function of the C-terminal propeptide, J Biol Chem, 272, 9640, 10.1074/jbc.272.15.9640 Noah, 2003, Bronchoalveolar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis, Am J Respir Crit Care Med, 168, 685, 10.1164/rccm.200301-005OC Okada, 1997, Early role of Fsp1 in epithelial-mesenchymal transformation, Am J Physiol, 273, F563 Okada, 1998, Identification of a novel cis-acting element for fibroblast-specific transcription of the FSP1 gene, Am J Physiol, 275, F306 Iwano, 2001, Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts, Mol Ther, 3, 149, 10.1006/mthe.2000.0251 Iwano, 2002, Evidence that fibroblasts derive from epithelium during tissue fibrosis, J Clin Invest, 110, 341, 10.1172/JCI0215518 Weaver, 2001, Function of surfactant proteins B and C, Annu Rev Physiol, 63, 555, 10.1146/annurev.physiol.63.1.555 Glasser, 2003, Pneumonitis and emphysema in sp-C gene targeted mice, J Biol Chem, 278, 14291, 10.1074/jbc.M210909200 Ikegami, 2002, Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury, J Appl Physiol, 92, 519, 10.1152/japplphysiol.00459.2001 Hawgood, 1996, Lung function in premature rabbits treated with recombinant human surfactant protein-C, Am J Respir Crit Care Med, 154, 484, 10.1164/ajrccm.154.2.8756826 Davis, 1998, Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant, Am J Respir Crit Care Med, 157, 553, 10.1164/ajrccm.157.2.97-08019 Hafner, 1998, Effects of rSP-C surfactant on oxygenation and histology in a rat-lung-lavage model of acute lung injury, Am J Respir Crit Care Med, 158, 270, 10.1164/ajrccm.158.1.9712061 Lewis, 1999, Dosing and delivery of a recombinant surfactant in lung-injured adult sheep, Am J Respir Crit Care Med, 159, 741, 10.1164/ajrccm.159.3.9806069 Spragg, 2000, Effect of recombinant SP-C surfactant in a porcine lavage model of acute lung injury, J Appl Physiol, 88, 674, 10.1152/jappl.2000.88.2.674 Floros, 1998, Genetics of the hydrophilic surfactant proteins A and D, Biochim Biophys Acta, 1408, 312, 10.1016/S0925-4439(98)00077-5 Hay, 1991, Mechanisms of bleomycin-induced lung damage, Arch Toxicol, 65, 81, 10.1007/BF02034932 Savani, 2001, Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C, Am J Physiol, 281, L685 Schmidt, 2004, Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis, Toxicol Appl Pharmacol, 195, 218, 10.1016/j.taap.2003.11.011 Hagimoto, 1997, Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice, Am J Respir Cell Mol Biol, 16, 91, 10.1165/ajrcmb.16.1.8998084 Kuwano, 1999, Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis, J Clin Invest, 104, 13, 10.1172/JCI5628 Wang, 2000, Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor, Am J Physiol, 279, L143 Kuwano, 2001, Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor, Am J Physiol, 280, L316 Lee, 2004, Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis, J Exp Med, 200, 377, 10.1084/jem.20040104 Uhal, 1998, Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung, Am J Physiol, 275, L1192 Uhal, 2002, Apoptosis in lung fibrosis and repair, Chest, 122, 293S, 10.1378/chest.122.6_suppl.293S Kuwano, 1996, P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis, Am J Respir Crit Care Med, 154, 477, 10.1164/ajrccm.154.2.8756825 Selman, 2001, Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy, Ann Intern Med, 134, 136, 10.7326/0003-4819-134-2-200101160-00015 Whitsett, 2002, Hydrophobic surfactant proteins in lung function and disease, N Engl J Med, 347, 2141, 10.1056/NEJMra022387 Nogee, 2002, Abnormal expression of surfactant protein C and lung disease, Am J Respir Cell Mol Biol, 26, 641, 10.1165/ajrcmb.26.6.f241 Beers, 1998, Synthetic processing of surfactant protein C by alevolar epithelial cells. The COOH terminus of proSP-C is required for post-translational targeting and proteolysis, J Biol Chem, 273, 15287, 10.1074/jbc.273.24.15287 Keller, 1992, The C-terminal domain of the pulmonary surfactant protein C precursor contains signals for intracellular targeting, Am J Respir Cell Mol Biol, 6, 601, 10.1165/ajrcmb/6.6.601 Mulugeta, 2005, A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation, Am J Respir Cell Mol Biol, 32, 521, 10.1165/rcmb.2005-0009OC Bridges, 2003, Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice, J Biol Chem, 278, 52739, 10.1074/jbc.M309599200