Increased Plasma Nitric Oxide Metabolites in Suicide Attempters

Neuropsychobiology - Tập 53 Số 3 - Trang 127-132 - 2006
Bun-Hee Lee1, Sung-Woo Lee2, Dokyung Yoon3, Heon‐Jeong Lee3, Jong‐Chul Yang4, Se-Hoon Shim5, Do‐Hoon Kim6, Seung‐Ho Ryu7, Hans‐Jürgen Möller3, Yong‐Ku Kim3
1Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea
2Dongguk University
3Korea University
4Chonnam National University Hospital
5Soonchunhyang University
6Hallym University
7Konkuk University

Tóm tắt

<i>Objective:</i> To evaluate any correlation between plasma levels of nitric oxide metabolites (NO<sub>x</sub>) and suicide attempt. <i>Method:</i> Plasma NO<sub>x</sub> levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden’s Risk-Rescue Rating Scale. <i>Results:</i> Plasma NO<sub>x</sub> levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NO<sub>x</sub> levels than nonsuicidal depressive patients (t = –3.090, d.f. = 84, p = 0.003). <i>Conclusion:</i> Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.

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10.1146%2Fannurev.bi.63.070194.001135

10.1016%2FS0306-4522%2897%2900461-2

10.1016%2FS0920-9964%2801%2900388-7

10.1016%2Fj.biopsych.2004.03.003

10.1046%2Fj.1471-4159.2001.00108.x

10.1038%2Fsj.npp.1300187

10.1016%2F0165-1781%2888%2990007-8

10.1176%2Fappi.ajp.158.5.748

10.1016%2F0006-8993%2893%2990666-B

10.1016%2FS0165-0327%2800%2900164-6

10.1016%2F0278-5846%2895%2900019-R

10.1016%2FS0006-3223%2898%2900382-5

10.1126%2Fscience.7508638

10.1006%2Ffrne.1997.0156

10.1016%2Fj.yhbeh.2003.02.002

10.1016%2F0006-3223%2894%2990643-2

10.1055%2Fs-2007-979181

10.1034%2Fj.1600-0447.2002.10352.x

10.1016%2FS0165-0327%2803%2900166-6

10.1016%2FS0006-3223%2898%2900160-7

10.1172%2FJCI4829

10.1002%2Fclc.4960200412

10.1016%2Fj.jad.2004.08.009

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Neuropsychobiology

Tập 53 Số 3

127-132

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