Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr -/- ApoB 100/100 mouse model

Otto, 1999, Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly, N Engl J Med, 341, 142, 10.1056/NEJM199907153410302 Lindman, 2016, Calcific aortic stenosis, Nat Rev Dis Primers, 2, 16006, 10.1038/nrdp.2016.6 Iung, 2003, A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease, Eur Heart J, 24, 1231, 10.1016/S0195-668X(03)00201-X Mozaffarian, 2015, Heart disease and stroke statistics--2015 update: a report from the American Heart Association, Circulation, 131, e29, 10.1161/CIR.0000000000000152 Mozaffarian, 2016, Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association, Circulation, 133, e38, 10.1161/CIR.0000000000000350 Carabello, 2013, Introduction to aortic stenosis, Circ Res, 113, 179, 10.1161/CIRCRESAHA.113.300156 Mazzone, 2008, Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies, Lancet, 371, 1800, 10.1016/S0140-6736(08)60768-0 Katz, 2009, Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA), Diabetes, 58, 813, 10.2337/db08-1515 Nishimura, 2016, Predictors of Rapid Progression and Clinical Outcome of Asymptomatic Severe Aortic Stenosis, Circ J, 80, 1863, 10.1253/circj.CJ-16-0333 Briand, 2006, Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis, J Am Coll Cardiol, 47, 2229, 10.1016/j.jacc.2005.12.073 Mosch, 2017, Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus, Histol Histopathol, 32, 293 Rossebø, 2004, Hyperlipidaemia and aortic valve disease, Curr Opin Lipidol, 15, 447, 10.1097/01.mol.0000137229.00020.fe Rossebø, 2007, Design and baseline characteristics of the simvastatin and ezetimibe in aortic stenosis (SEAS) study, Am J Cardiol, 99, 970, 10.1016/j.amjcard.2006.10.064 Rossebø, 2008, Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis, N Engl J Med, 359, 1343, 10.1056/NEJMoa0804602 Teo, 2011, Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients, Can J Cardiol, 27, 800, 10.1016/j.cjca.2011.03.012 Agmon, 2001, Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study, J Am Coll Cardiol, 38, 827, 10.1016/S0735-1097(01)01422-X van Rosendael, 2016, Comparison of Quantity of Calcific Deposits by Multidetector Computed Tomography in the Aortic Valve and Coronary Arteries, Am J Cardiol, 118, 1533, 10.1016/j.amjcard.2016.08.021 Weisenberg, 2005, Atherosclerosis of the aorta is common in patients with severe aortic stenosis: an intraoperative transesophageal echocardiographic study, J Thorac Cardiovasc Surg, 130, 29, 10.1016/j.jtcvs.2004.11.040 Freeman, 2005, Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies, Circulation, 111, 3316, 10.1161/CIRCULATIONAHA.104.486738 Galli, 2017, Understanding the structural features of symptomatic calcific aortic valve stenosis: A broad-spectrum clinico-pathologic study in 236 consecutive surgical cases, Int J Cardiol, 228, 364, 10.1016/j.ijcard.2016.11.180 Nguyen, 2013, Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant mice, Cardiovasc Pathol, 22, 167, 10.1016/j.carpath.2012.06.007 Naik, 2012, Sources of Cells that Contribute to Atherosclerotic Intimal Calcification: an In Vivo Genetic Fate Mapping Study, Cardiovasc Res, 94, 545, 10.1093/cvr/cvs126 Baumgartner, 2009, Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice, J Am Soc Echocardiogr, 22, 1, 10.1016/j.echo.2008.11.029 Baumgartner, 2017, Recommendations on the Echocardiographic Assessment of Aortic Valve Stenosis: A Focused Update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography, J Am Soc Echocardiogr, 30, 372, 10.1016/j.echo.2017.02.009 Pai, 2011, Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease, Am J Pathol, 178, 764, 10.1016/j.ajpath.2010.10.006 Callegari, 2013, Bone Marrow- or Vessel Wall-Derived Osteoprotegerin Is Sufficient to Reduce Atherosclerotic Lesion Size and Vascular Calcification, Arterioscler Thromb Vasc Biol, 33, 2491, 10.1161/ATVBAHA.113.301755 Speer, 2009, Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries, Circ Res, 104, 733, 10.1161/CIRCRESAHA.108.183053 Steitz, 2001, Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers, Circ Res, 89, 1147, 10.1161/hh2401.101070 Wiester, 2003, Expression and function of the integrin alpha9beta1 in bovine aortic valve interstitial cells, J Heart Valve Dis, 12, 605 Speer, 2005, Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro, Cardiovasc Res, 66, 324, 10.1016/j.cardiores.2005.01.023 Drolet, 2006, A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice, J Am Coll Cardiol, 47, 850, 10.1016/j.jacc.2005.09.049 Otto, 2014, Aortic-valve stenosis--from patients at risk to severe valve obstruction, N Engl J Med, 371, 744, 10.1056/NEJMra1313875 Miller, 2009, Lowering plasma cholesterol levels halts progression of aortic valve disease in mice, Circulation, 119, 2693, 10.1161/CIRCULATIONAHA.108.834614 Miller, 2010, Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease, Arterioscler Thromb Vasc Biol, 30, 2482, 10.1161/ATVBAHA.110.211029 Weiss, 2006, Calcific aortic valve stenosis in old hypercholesterolemic mice, Circulation, 114, 2065, 10.1161/CIRCULATIONAHA.106.634139 Le Quang, 2014, Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus, Arterioscler Thromb Vasc Biol, 34, 2283, 10.1161/ATVBAHA.114.304205 Mjaatvedt, 2005, Normal distribution of melanocytes in the mouse heart, Anat Rec A Discov Mol Cell Evol Biol, 285, 748, 10.1002/ar.a.20210 Heinonen, 2011, Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice, Cardiovasc Diabetol, 10, 59, 10.1186/1475-2840-10-59 Fahed, 2017, Premature Valvular Heart Disease in Homozygous Familial Hypercholesterolemia, Cholesterol, 2017, 3685265, 10.1155/2017/3685265 Hjortnaes, 2010, Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation, Eur Heart J, 31, 1975, 10.1093/eurheartj/ehq237 Yahagi, 2017, Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus, Arterioscler Thromb Vasc Biol, 37, 191, 10.1161/ATVBAHA.116.306256 Suga, 2011, Activation of receptor for advanced glycation end products induces osteogenic differentiation of vascular smooth muscle cells, J Atheroscler Thromb, 18, 670, 10.5551/jat.7120 Chen, 2006, High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells, Nephrol Dial Transplant, 21, 3435, 10.1093/ndt/gfl429 Liu, 2011, Signalling pathways and vascular calcification, Front Biosci, 16, 1302, 10.2741/3790 Zhou, 2011, Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium, Cell Metab, 13, 592, 10.1016/j.cmet.2011.02.016