Increase of adenosine plasma levels after oral trimetazidine: A pharmacological preconditioning?

Harpey, 1989, Trimetazidine, a cellular antischemic agent, Cardiovasc Drugs Rev, 6, 292, 10.1111/j.1527-3466.1988.tb00381.x Sellier, 1987, Acute effects of trimetazidine evaluated by exercise testing, Eur J Clin Pharmacol, 33, 205, 10.1007/BF00544569 Passeron, 1986, Efficacy of trimetazidine in stable effort angina of chronic coronary artery disease. Double blind study against placebo, Presse Med, 15, 1775 Sellier, 1986, Effects de la trimétazidine sur les paramètres ergométriques dans l’angor d’effort. Etude multicentrique controlé à double insu contre placebo, Arch Mal Coeur, 9, 1331 Dalla Volta, 1990, Comparison of trimetazidine in stable effort angina: a double blind cross-over study, Cardiovasc Drug Ther, 4, 853, 10.1007/BF00051292 Detry, 1994, Trimetazidine: a new concept in the teatment of angina. Comparison with propranolol in patients with stable angina, Br J Clin Pharmacol, 37, 279, 10.1111/j.1365-2125.1994.tb04276.x Brochier, 1986, Therapeutic value of a combination of trimetazidine and a calcium antagonists for the treatment of chronic artery disease. Controlled, double blind study against placebo, Presse Med, 15, 1783 Michaelides, 1987, Beneficial effects of trimetazidine in patients with stable angina under beta-blockers, Cardiovasc Drug Ther, 1, 268 Levy, 1995, Combination therapy of trimetazidine with diltiazem in patients with coronary artery disease, Am J Cardiol, 76, 12B, 10.1016/S0002-9149(99)80456-1 Kober, 1992, Myocardial protection during percutaneous transluminal coronary angioplasty: effects of trimetazidine, Eur Heart J, 13, 1109, 10.1093/oxfordjournals.eurheartj.a060322 Steg, 1998, A randomized double-blind trial of trimetazidine as adjunctive therapy to primary PTCA for acute myocardial infarction: evidence for improved myocardial reperfusion from ST-segment analysis (abstract), Eur Heart J, 19 (Abstract Suppl.), 365 Fabiani, 1992, Cardioprotective effect of trimetazidine during coronary artery graft surgery, Cardiovasc Surg, 33, 486 Vedrinne, 1996, Myocardial protection during coronary artery bypass graft surgery: a randomized, double mind, placebo controlled study with trimetazidine, Anesth Analg, 82, 712 Lavanchy, 1987, Antischemic effects of Trimetazidine:31P-NMR Spectroscopy in the isolated rat heart, Arch Int Pharmacodyn Ther, 286, 97 Kantor, 2000, The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3- ketoacyl coenzyme A thiolase, Circ Res, 86, 487, 10.1161/01.RES.86.5.580 Renaud, 1988, Internal pH, Na+and Ca2+regulation by trimetazidine during cardiac cell acidosis, Cardiovasc Drugs Ther, 1, 677, 10.1007/BF02125756 Maupoil, 1990, Direct measurement of free radical generation in isolated rat heart by electron paramagnetic resonance spectroscopy: effect of trimetazidine, Adv Exp Med Biol, 264, 377 Maridonneau-Parini, 1985, Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells, Br J Clin Pharm, 20, 148, 10.1111/j.1365-2125.1985.tb05047.x Williams, 1993, Trimetazidine inhibits neutrophil accumulation after myocardial ischemia and reperfusion in rabbits, J Cardiovasc Pharmacol, 22, 828, 10.1097/00005344-199312000-00008 Murry, 1986, Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium, Circulation, 76, 1124, 10.1161/01.CIR.74.5.1124 Scott, 1990, Ischemic preconditioning reduces infarct size in swine myocardium, Circ Res, 66, 1133, 10.1161/01.RES.66.4.1133 Li, 1990, Myocardial protection with preconditioning, Circulation, 82, 609, 10.1161/01.CIR.82.2.609 Heurteaux, 1995, Essential role of adenosine, adenosine A1 receptors and ATP-sensitive K+channels in cerebral ischemic preconditioning, Proc Natl Acad Sci USA, 92, 4666, 10.1073/pnas.92.10.4666 Liu, 1991, Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart, Circulation, 84, 350, 10.1161/01.CIR.84.1.350 Thornton, 1992, Intravenous treatment with A1-selective adenosine analogues protects the heart against infarction, Circulation, 85, 659, 10.1161/01.CIR.85.2.659 Mosca, 1994, Adenosine and dipyridamole mimic the effects of ischemic preconditioning, J Mol Cell Cardiol, 26, 1403, 10.1006/jmcc.1994.1158 Ely, 1992, Protective effects of adenosine in myocardial ischemia, Circulation, 85, 893, 10.1161/01.CIR.85.3.893 Ontyd, 1984, Measurement of adenosine, inosine and hypoxantine in human plasma, J Chromatogr, 307, 404, 10.1016/S0378-4347(00)84113-4 Forgue, 1991, Pharmacodynamic models in bioequivalence, 301 Naito, 1972, Trimetazidine in blood, bile, organs and urine, Chem Pharm Buil, 20, 632 Goupit, 1987, Pharmacocinétique de la trimétazidine, Concours Med, 36 (Suppl 36), 3447 Noble, 1995, Limitation of infarct size by trimetazidine in the rabbit, Am J Cardiol, 76, 41B, 10.1016/S0002-9149(99)80461-5 Blardi, 1993, Pharmacokinetics of exogenous adenosine in man after infusion, Eur J Clin Pharmacol, 44, 505, 10.1007/BF00315554 Tomai, 1999, Ischemic preconditioning in humans: models, mediators and clinical relevance, Circulation, 100, 559, 10.1161/01.CIR.100.5.559